ADAM12 and FSTL3

Number of citations of the paper that reports this interaction (PMID 15574124)
5

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ADAM12	FSTL3
Gene Name		ADAM metallopeptidase domain 12	follistatin-like 3 (secreted glycoprotein)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleoplasm Mitochondrion Plasma Membrane Integral Component Of Membrane	Extracellular Region Extracellular Space Nucleus Nucleoplasm Golgi Apparatus Secretory Granule Neuron Projection Terminus
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding	Fibronectin Binding Protein Binding Activin Binding
	Biological Process	Proteolysis Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Myoblast Fusion	Ossification Kidney Development Hematopoietic Progenitor Cell Differentiation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Spermatogenesis Male Gonad Development Positive Regulation Of Cell-cell Adhesion Lung Development Adrenal Gland Development Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Metal Ion Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Pathways		Signaling by EGFR Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer	Antagonism of Activin by Follistatin Signaling by Activin
Drugs
Diseases
GWAS		Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)
Protein-Protein Interactions		11 interactors: ACTN2 EGF FSTL3 GRB2 IGFBP3 IGFBP5 PACSIN3 PIK3R1 SH3D19 SRC YES1	5 interactors: ADAM12 FN1 INHBA MSTN SMAD4
Entrez ID		8038	10272
HPRD ID		04092	05632
Ensembl ID		ENSG00000148848	ENSG00000070404
Uniprot IDs		A8K6G4 O43184	O95633
PDB IDs			2KCX 3B4V 3SEK
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Platelet Activation Vesicle-mediated Transport T Cell Costimulation Positive Regulation Of Cell-cell Adhesion Fc Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Regulation Of Cellular Component Organization Response To Wounding Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Carbohydrate Metabolic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Smooth Muscle Cell Migration Immune Response-regulating Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Organonitrogen Compound Response To Fibroblast Growth Factor Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway Leukocyte Migration Negative Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Phagocytosis Regulation Of Cell Adhesion Negative Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cell Activation Positive Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Regulation Of Signaling Regulation Of Immune System Process Cellular Response To Peptide	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Endoderm Development Regulation Of Growth Gastrulation Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Growth Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cellular Protein Metabolic Process Endodermal Cell Differentiation Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Endoderm Formation Cell Differentiation Growth Regulation Of Cell Differentiation Tissue Development Cell Development Ovulation Cycle Process Embryonic Morphogenesis Palate Development Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Negative Regulation Of Myoblast Proliferation Negative Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Cell Proliferation Regulation Of Cellular Protein Metabolic Process Ovulation Cycle Positive Regulation Of Protein Phosphorylation Negative Regulation Of Cell Differentiation Formation Of Primary Germ Layer Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Mesoderm Development Anatomical Structure Development Progesterone Secretion Nephrogenic Mesenchyme Morphogenesis Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Cell Growth Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Phosphorylation Anatomical Structure Morphogenesis Positive Regulation Of Protein Modification Process Cellular Response To Transforming Growth Factor Beta Stimulus Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Response To Transforming Growth Factor Beta
Tagcloud ?		alpha1 anchoring balanced brdu cct ccts cytotrophoblasts eclampsia evt evts exaggerated explant extravillous fibronectin floating hes1 labelling maml notch outgrowth overgrowth placental rbpjkappa sirnas trimester trophoblast trophoblasts villi villous
Tagcloud (Difference) ?		alpha1 anchoring balanced brdu cct ccts cytotrophoblasts eclampsia evt evts exaggerated explant extravillous fibronectin floating hes1 labelling maml notch outgrowth overgrowth placental rbpjkappa sirnas trimester trophoblast trophoblasts villi villous
Tagcloud (Intersection) ?