ADAM12

Gene Name		ADAM metallopeptidase domain 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleoplasm Mitochondrion Plasma Membrane Integral Component Of Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding
	Biological Process	Proteolysis Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Myoblast Fusion
Pathways		Signaling by EGFR Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS		Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)
Protein-protein Interactions		11 interactors: ACTN2 EGF FSTL3 GRB2 IGFBP3 IGFBP5 PACSIN3 PIK3R1 SH3D19 SRC YES1
Entrez ID		8038
HPRD ID		04092
Ensembl ID		ENSG00000148848
Uniprot IDs		A8K6G4 O43184
PDB IDs
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Platelet Activation Vesicle-mediated Transport T Cell Costimulation Positive Regulation Of Cell-cell Adhesion Fc Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Regulation Of Cellular Component Organization Response To Wounding Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Carbohydrate Metabolic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Smooth Muscle Cell Migration Immune Response-regulating Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Organonitrogen Compound Response To Fibroblast Growth Factor Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway Leukocyte Migration Negative Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Phagocytosis Regulation Of Cell Adhesion Negative Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cell Activation Positive Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Regulation Of Signaling Regulation Of Immune System Process Cellular Response To Peptide
Tagcloud ?		alpha1 anchoring balanced brdu cct ccts cytotrophoblasts eclampsia evt evts exaggerated explant extravillous fibronectin floating hes1 labelling maml notch outgrowth overgrowth placental rbpjkappa sirnas trimester trophoblast trophoblasts villi villous