BMPR1A and GDF9

Number of citations of the paper that reports this interaction (PubMedID 10712517)
57

Data Source:
HPRD (in vivo)

		BMPR1A	GDF9
Description		bone morphogenetic protein receptor type 1A	growth differentiation factor 9
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Caveola External Side Of Plasma Membrane Cell Surface Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Transferase Activity BMP Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding BMP Receptor Activity	Cytokine Activity Growth Factor Activity
	Biological Process	Angiogenesis Osteoblast Differentiation In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Valve Development Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Ventricular Compact Myocardium Morphogenesis Endocardial Cushion Formation Intracellular Iron Ion Homeostasis Immune Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Pattern Specification Process Ectoderm Development Nervous System Development Endoderm Development Heart Development Dorsal/ventral Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Negative Regulation Of Smooth Muscle Cell Migration Central Nervous System Neuron Differentiation Pituitary Gland Development Neural Plate Mediolateral Regionalization Cell Differentiation Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta2 Production Somatic Stem Cell Population Maintenance Hindlimb Morphogenesis Dorsal Aorta Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Embryonic Morphogenesis Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Negative Regulation Of Muscle Cell Differentiation Cartilage Development Roof Of Mouth Development Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Neural Plate Pattern Specification Heart Formation Atrioventricular Node Cell Development Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Dendrite Development Positive Regulation Of MiRNA Transcription Positive Regulation Of Cardiac Ventricle Development Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Fibrous Ring Of Heart Morphogenesis Regulation Of Neural Crest Cell Differentiation Anti-Mullerian Hormone Receptor Signaling Pathway Regulation Of Cellular Senescence	Oocyte Growth Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Female Gamete Generation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Regulation Of Progesterone Secretion
Pathways		Signaling by BMP
Drugs		Dibotermin alfa
Diseases		Juvenile polyposis syndrome Hereditary mixed polyposis syndrome
GWAS		Apolipoprotein A1 levels ( 32203549) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32203549) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	Asthma ( 31619474)
Interacting Genes		45 interacting genes: ACVR1 ALDOB AOPEP BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 CDK8 CRIPTO CTSV FANCC FBP1 FBP2 FKBP1A FKBP1B GALNT12 GDF5 GDF6 GDF9 HOXC8 HRAS IGFBP3 MAP2K1 MSANTD3 NEDD4 NEDD4L OTUB1 RASA1 SEC61B SF3B4 SFRP2 SFRP4 SMAD1 TAB1 TGFB1 TGFBRAP1 TRMO USP15 XPA ZMYND11 ZNF189	45 interacting genes: ACVR2A ADPGK ANXA7 APLP1 BMP15 BMPR1A BMPR1B BMPR2 BTBD2 CDKN1A CDKN2C CRELD1 CRIPTO DLEU1 DNM2 FOXG1 FXYD6 GADD45G ILF3 KDM1A KIF22 LSM3 MOB4 MPHOSPH6 MYCBP NDUFB9 ORAI2 PABPC4 PAFAH1B3 PCDHA4 PCYT2 PMF1 PRKRA PSMD11 RAB27A RSRC1 S100A8 SAT1 SERPINB9 SMN1 SNRPG STRN4 TK1 TRIB3 WASHC3
Entrez ID		657	2661
HPRD ID		03192	03560
Ensembl ID		ENSG00000107779	ENSG00000164404
Uniprot IDs		P36894	B4DXG3 O60383
PDB IDs		1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Positive Regulation Of Signal Transduction Cellular Response To BMP Stimulus Regulation Of Osteoblast Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Growth Factor Activity Cartilage Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Intracellular Signal Transduction Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development BMP Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Ossification Anatomical Structure Morphogenesis Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Regulation Of Signaling Regulation Of Cell Communication Regulation Of Ossification Regulation Of Bone Mineralization Positive Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Cytokine Activity Regulation Of Primary Metabolic Process Pattern Specification Process Regulation Of Nucleobase-containing Compound Metabolic Process Animal Organ Morphogenesis Response To Growth Factor Mesenchyme Development Positive Regulation Of Epithelial To Mesenchymal Transition Endocardial Cushion Formation Signal Transduction Regulation Of RNA Metabolic Process Heart Development	BMP Receptor Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Cellular Response To BMP Stimulus Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type II BMP Binding Positive Regulation Of Osteoblast Differentiation Tricuspid Valve Morphogenesis Activin Receptor Signaling Pathway Regulation Of Bone Mineralization BMP Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Negative Regulation Of Chondrocyte Proliferation Regionalization Endochondral Bone Morphogenesis Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Developmental Process Positive Regulation Of SMAD Protein Signal Transduction HFE-transferrin Receptor Complex Mitral Valve Morphogenesis RNA Splicing, Via Transesterification Reactions Regulation Of Ossification Pharyngeal Arch Artery Morphogenesis Osteoblast Differentiation Mesenchyme Development Endocardial Cushion Development Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Positive Regulation Of Programmed Cell Death Pattern Specification Process Regulation Of Osteoblast Differentiation Dorsal/ventral Pattern Formation Cellular Response To Growth Factor Stimulus Regulation Of SMAD Protein Signal Transduction Cellular Developmental Process Cell Differentiation SMN-Sm Protein Complex FAR/SIN/STRIPAK Complex Anterior/posterior Pattern Specification Kinase Activity Precatalytic Spliceosome Atrioventricular Valve Morphogenesis Epithelial Cell Proliferation Protein Binding
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