BMPR1A and FKBP1B

Number of citations of the paper that reports this interaction (PubMedID 15351706)
0

Data Source:
BioGRID (two hybrid)

		BMPR1A	FKBP1B
Description		bone morphogenetic protein receptor type 1A	FKBP prolyl isomerase 1B
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GO Annotations	Cellular Component	Plasma Membrane Caveola External Side Of Plasma Membrane Cell Surface Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex	Cytoplasm Membrane Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Membrane Calcium Channel Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Transferase Activity BMP Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding BMP Receptor Activity	Peptidyl-prolyl Cis-trans Isomerase Activity Signaling Receptor Binding Calcium Channel Regulator Activity Protein Binding FK506 Binding Isomerase Activity Calcium Channel Inhibitor Activity Transmembrane Transporter Binding
	Biological Process	Angiogenesis Osteoblast Differentiation In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Valve Development Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Ventricular Compact Myocardium Morphogenesis Endocardial Cushion Formation Intracellular Iron Ion Homeostasis Immune Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Pattern Specification Process Ectoderm Development Nervous System Development Endoderm Development Heart Development Dorsal/ventral Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Negative Regulation Of Smooth Muscle Cell Migration Central Nervous System Neuron Differentiation Pituitary Gland Development Neural Plate Mediolateral Regionalization Cell Differentiation Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta2 Production Somatic Stem Cell Population Maintenance Hindlimb Morphogenesis Dorsal Aorta Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Embryonic Morphogenesis Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Negative Regulation Of Muscle Cell Differentiation Cartilage Development Roof Of Mouth Development Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Neural Plate Pattern Specification Heart Formation Atrioventricular Node Cell Development Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Dendrite Development Positive Regulation Of MiRNA Transcription Positive Regulation Of Cardiac Ventricle Development Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Fibrous Ring Of Heart Morphogenesis Regulation Of Neural Crest Cell Differentiation Anti-Mullerian Hormone Receptor Signaling Pathway Regulation Of Cellular Senescence	Regulation Of Heart Rate Protein Folding 'de Novo' Protein Folding Smooth Muscle Contraction Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Glucose Negative Regulation Of Heart Rate Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Neuronal Action Potential Propagation Calcium-mediated Signaling Insulin Secretion Insulin Secretion Involved In Cellular Response To Glucose Stimulus Protein Refolding T Cell Proliferation Negative Regulation Of Calcium-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Protein Maturation Response To Redox State Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Pathways		Signaling by BMP	Stimuli-sensing channels Ion homeostasis
Drugs		Dibotermin alfa
Diseases		Juvenile polyposis syndrome Hereditary mixed polyposis syndrome
GWAS		Apolipoprotein A1 levels ( 32203549) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32203549) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	Chronotype ( 27494321) Quantitative traits ( 19197348)
Interacting Genes		45 interacting genes: ACVR1 ALDOB AOPEP BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 CDK8 CRIPTO CTSV FANCC FBP1 FBP2 FKBP1A FKBP1B GALNT12 GDF5 GDF6 GDF9 HOXC8 HRAS IGFBP3 MAP2K1 MSANTD3 NEDD4 NEDD4L OTUB1 RASA1 SEC61B SF3B4 SFRP2 SFRP4 SMAD1 TAB1 TGFB1 TGFBRAP1 TRMO USP15 XPA ZMYND11 ZNF189	12 interacting genes: ADAMTSL4 BMPR1A CAMK2D GMCL1 KRT31 KRT40 KRTAP1-1 REL RYR2 RYR3 TGFBR1 TRIM69
Entrez ID		657	2281
HPRD ID		03192	02795
Ensembl ID		ENSG00000107779	ENSG00000119782
Uniprot IDs		P36894	F8W6G9 P68106
PDB IDs		1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4	1C9H 4C02 4IQ2 4IQC 5HKG 5L1D 5T15 5T9M 5T9N 5T9R 5T9S 5T9V 5TA3 5TAL 5TAM 5TAN 5TAP 5TAQ 5TAS 5TAT 5TAU 5TAV 5TAW 5TAX 5TAY 5TAZ 5TB0 5TB1 5TB2 5TB3 5TB4 6JGZ 6JH6 6JHN 6JI0 6JI8 6JII 6JIU 6JIY 6JRR 6JRS 6M2W 6PV6 6W1N 6WOT 6WOU 6WOV 6X32 6X33 6X34 6X35 6X36 7CF9 7JMF 7JMG 7JMH 7JMI 7JMJ 7M6A 7M6L 7T64 7T65 7U9Q 7U9R 7U9T 7U9X 7U9Z 7UA1 7UA3 7UA4 7UA5 7UA9 7VML 7VMM 7VMN 7VMO 7VMP 7VMQ 7VMR 7VMS 8DTY 8DTZ 8DUJ 8DVE 8DVV 8SEN 8SEO 8SEP 8SEQ 8SER 8SES 8SET 8UQ2 8UQ3 8UQ4 8UXC 8UXE 8UXF 8UXG 8UXH 8UXI 8UXL 8UXM 8XJI 8XKH 8XLF 8XLH 8Y40 9C1E 9C1F 9CGP 9CGQ
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Positive Regulation Of Signal Transduction Cellular Response To BMP Stimulus Regulation Of Osteoblast Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Growth Factor Activity Cartilage Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Intracellular Signal Transduction Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development BMP Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Ossification Anatomical Structure Morphogenesis Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Regulation Of Signaling Regulation Of Cell Communication Regulation Of Ossification Regulation Of Bone Mineralization Positive Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Cytokine Activity Regulation Of Primary Metabolic Process Pattern Specification Process Regulation Of Nucleobase-containing Compound Metabolic Process Animal Organ Morphogenesis Response To Growth Factor Mesenchyme Development Positive Regulation Of Epithelial To Mesenchymal Transition Endocardial Cushion Formation Signal Transduction Regulation Of RNA Metabolic Process Heart Development	Ventricular Cardiac Muscle Tissue Morphogenesis Tissue Morphogenesis Transforming Growth Factor Beta Receptor Activity, Type I Sarcoplasmic Reticulum Membrane Calcium-induced Calcium Release Activity Ryanodine-sensitive Calcium-release Channel Activity Cardiac Muscle Tissue Morphogenesis Muscle Tissue Morphogenesis Ventricular Compact Myocardium Morphogenesis Sarcoplasmic Reticulum Intracellularly Gated Calcium Channel Activity Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cellular Response To Caffeine Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Transmembrane Receptor Protein Serine/threonine Kinase Activity Cellular Response To Purine-containing Compound Keratin Filament Ventricular Trabecula Myocardium Morphogenesis Sarcoplasmic Reticulum Calcium Ion Transport Response To Caffeine Sarcolemma Smooth Endoplasmic Reticulum Heart Trabecula Morphogenesis Regulation Of Sequestering Of Calcium Ion Response To Calcium Ion Intracellular Monoatomic Cation Homeostasis Inorganic Ion Homeostasis Intracellular Monoatomic Ion Homeostasis Regulation Of The Force Of Heart Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Channel Complex Intermediate Filament Regulation Of Cardiac Muscle Cell Action Potential Calcium-mediated Signaling Monoatomic Cation Homeostasis Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Monoatomic Ion Homeostasis Intracellular Calcium Ion Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Calmodulin Binding Cellular Response To Alkaloid Ventricular Septum Morphogenesis Regulation Of Cardiac Muscle Cell Proliferation Intracellular Chemical Homeostasis Positive Regulation Of SMAD Protein Signal Transduction Calcium Ion Homeostasis SMAD Binding Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Neural Crest Cell Differentiation Neural Plate Mediolateral Regionalization
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