BMPR1A and GDF5

Number of citations of the paper that reports this interaction (PubMedID 9525338)
0

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		BMPR1A	GDF5
Description		bone morphogenetic protein receptor type 1A	growth differentiation factor 5
Image
GO Annotations	Cellular Component	Plasma Membrane Caveola External Side Of Plasma Membrane Cell Surface Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex	Extracellular Region Extracellular Space Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Kinase Activity Transferase Activity BMP Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding BMP Receptor Activity	Signaling Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity BMP Binding Identical Protein Binding
	Biological Process	Angiogenesis Osteoblast Differentiation In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Valve Development Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Ventricular Compact Myocardium Morphogenesis Endocardial Cushion Formation Intracellular Iron Ion Homeostasis Immune Response Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Pattern Specification Process Ectoderm Development Nervous System Development Endoderm Development Heart Development Dorsal/ventral Axis Specification Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Cardiac Muscle Cell Apoptotic Process Neural Crest Cell Development Negative Regulation Of Smooth Muscle Cell Migration Central Nervous System Neuron Differentiation Pituitary Gland Development Neural Plate Mediolateral Regionalization Cell Differentiation Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta2 Production Somatic Stem Cell Population Maintenance Hindlimb Morphogenesis Dorsal Aorta Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Embryonic Morphogenesis Stem Cell Differentiation Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Negative Regulation Of Muscle Cell Differentiation Cartilage Development Roof Of Mouth Development Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Neural Plate Pattern Specification Heart Formation Atrioventricular Node Cell Development Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Dendrite Development Positive Regulation Of MiRNA Transcription Positive Regulation Of Cardiac Ventricle Development Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Fibrous Ring Of Heart Morphogenesis Regulation Of Neural Crest Cell Differentiation Anti-Mullerian Hormone Receptor Signaling Pathway Regulation Of Cellular Senescence	Chondrocyte Differentiation Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Response To Mechanical Stimulus Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of Chondrocyte Differentiation Forelimb Morphogenesis Hindlimb Morphogenesis Regulation Of Multicellular Organism Growth Negative Regulation Of Neuron Apoptotic Process Ossification Involved In Bone Remodeling Positive Regulation Of Neuron Differentiation Negative Regulation Of Epithelial Cell Proliferation Cartilage Development Positive Regulation Of SMAD Protein Signal Transduction Chondroblast Differentiation Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesenchymal Cell Apoptotic Process Negative Regulation Of Mesenchymal Cell Apoptotic Process
Pathways		Signaling by BMP	Molecules associated with elastic fibres
Drugs		Dibotermin alfa
Diseases		Juvenile polyposis syndrome Hereditary mixed polyposis syndrome	Other brachydactylies, including: Proximal symphalangism; Multiple synostosis syndrome Fibular hypoplasia and complex brachydactyly; DuPan syndrome Grebe dysplasia; Acromesomelic dysplasia Hunter-Thompson type Brachydactyly, including: Brachydactyly type C; Angel shaped phalangoepiphyseal dysplasia (ASPED)
GWAS		Apolipoprotein A1 levels ( 32203549) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32203549) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 32888494)	A body shape index ( 34021172) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Appendicular lean mass ( 33097823) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Femoral neck size ( 31053729) Height ( 18391951 34270706 33713608 31562340 28552196 18391950 18391952 20189936 20881960 23563607 25282103 25429064) Hip bone size ( 31053729) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 28552196 25673412) Infant length ( 25281659) Intertrochanteric region size ( 31053729) Joint mobility (Beighton score) ( 27182965) Knee osteoarthritis ( 30374069 30664745) Knee pain ( 31482140) Low hand grip strength (60 years and older) (EWGSOP) ( 33510174) Metabolite levels ( 23823483) Pulse pressure ( 30578418) Refractive error ( 32231278) Spine bone size ( 31053729) Trochanter size ( 31053729) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) Walking pace ( 33128006) Weight ( 28552196)
Interacting Genes		45 interacting genes: ACVR1 ALDOB AOPEP BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 CDK8 CRIPTO CTSV FANCC FBP1 FBP2 FKBP1A FKBP1B GALNT12 GDF5 GDF6 GDF9 HOXC8 HRAS IGFBP3 MAP2K1 MSANTD3 NEDD4 NEDD4L OTUB1 RASA1 SEC61B SF3B4 SFRP2 SFRP4 SMAD1 TAB1 TGFB1 TGFBRAP1 TRMO USP15 XPA ZMYND11 ZNF189	8 interacting genes: ACVR1 ACVR2A ACVR2B BMPR1A BMPR1B BMPR2 CHRDL2 HTRA1
Entrez ID		657	8200
HPRD ID		03192	03092
Ensembl ID		ENSG00000107779	ENSG00000125965
Uniprot IDs		P36894	F1T0J1 P43026
PDB IDs		1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4	1WAQ 2BHK 3EVS 3QB4 5HK5 6Z3G 6Z3H 6Z3J 6Z3L 6Z3M 7ZJF 8BWL 8BWM 8BWN 8E3G
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Osteoblast Differentiation Regulation Of Cartilage Development Positive Regulation Of Signal Transduction Cellular Response To BMP Stimulus Regulation Of Osteoblast Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Growth Factor Activity Cartilage Development Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Bone Mineralization Positive Regulation Of Intracellular Signal Transduction Osteoblast Differentiation Positive Regulation Of Biomineral Tissue Development BMP Receptor Binding Cell Surface Receptor Signaling Pathway Positive Regulation Of Ossification Anatomical Structure Morphogenesis Regulation Of Signal Transduction Positive Regulation Of Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Regulation Of Signaling Regulation Of Cell Communication Regulation Of Ossification Regulation Of Bone Mineralization Positive Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Cytokine Activity Regulation Of Primary Metabolic Process Pattern Specification Process Regulation Of Nucleobase-containing Compound Metabolic Process Animal Organ Morphogenesis Response To Growth Factor Mesenchyme Development Positive Regulation Of Epithelial To Mesenchymal Transition Endocardial Cushion Formation Signal Transduction Regulation Of RNA Metabolic Process Heart Development	Transmembrane Receptor Protein Serine/threonine Kinase Activity BMP Receptor Activity Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization BMP Signaling Pathway Cellular Response To BMP Stimulus Regulation Of Ossification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Growth Factor Binding Regulation Of Osteoblast Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type II BMP Binding Regionalization Cellular Response To Growth Factor Stimulus Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Activity, Type I Response To Growth Factor Osteoblast Differentiation Animal Organ Development Positive Regulation Of SMAD Protein Signal Transduction Activin Receptor Complex Mitral Valve Morphogenesis Pattern Specification Process Protein Serine/threonine Kinase Activity Mesoderm Development Receptor Complex Activin Binding Protein Kinase Activity Regulation Of SMAD Protein Signal Transduction Gastrulation With Mouth Forming Second Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Atrioventricular Valve Morphogenesis Cell Differentiation Regulation Of Activin Receptor Signaling Pathway Outflow Tract Septum Morphogenesis Endothelial Cell Differentiation Positive Regulation Of Cell Differentiation Anterior/posterior Pattern Specification Cellular Developmental Process Ventricular Septum Morphogenesis Regulation Of Signal Transduction Mesoderm Formation Gastrulation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?