GPI and LINC01554

Number of citations of the paper that reports this interaction (PubMedID 30809309)
42

Data Source:
BioGRID (unspecified method)

		GPI	LINC01554
Description		glucose-6-phosphate isomerase	long intergenic non-protein coding RNA 1554
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cytosol Plasma Membrane Membrane Secretory Granule Lumen Ciliary Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Glucose-6-phosphate Isomerase Activity Cytokine Activity Protein Binding Growth Factor Activity Isomerase Activity Ubiquitin Protein Ligase Binding Monosaccharide Binding Carbohydrate Derivative Binding
	Biological Process	In Utero Embryonic Development Mesoderm Formation Positive Regulation Of Immunoglobulin Production Carbohydrate Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Glycolytic Process Humoral Immune Response Signal Transduction Hemostasis Learning Or Memory Positive Regulation Of Endothelial Cell Migration Response To Estradiol Response To Progesterone Response To Testosterone Erythrocyte Homeostasis Response To Immobilization Stress Response To Muscle Stretch Glucose Homeostasis Negative Regulation Of Apoptotic Process Response To Cadmium Ion Glucose 6-phosphate Metabolic Process Canonical Glycolysis Carbohydrate Derivative Metabolic Process
Pathways		TP53 Regulates Metabolic Genes Neutrophil degranulation Glycolysis Gluconeogenesis
Drugs		alpha-D-glucose 6-phosphate 6-phospho-D-gluconic acid 5-phospho-D-arabinohydroxamic acid D-glucitol 6-phosphate 5-Phosphoarabinonic Acid Glucose-6-Phosphate D-erythrose 4-phosphate Fructose-6-phosphate Copper Artenimol
Diseases		Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mean corpuscular volume ( 32888494)	LDL cholesterol levels in HIV infection ( 33109212)
Interacting Genes		6 interacting genes: AMFR CSNK2A1 IGFBP3 LINC01554 PARP14 PCNA	141 interacting genes: AARS1 ACADVL ACIN1 ACTB ACTG1 ACTN1 ACTN3 ACTR3 ALDOA ANXA2 ANXA5 ANXA6 APEX1 ARHGAP1 ASS1 ATAD3A ATIC ATP5F1A BZW2 CANX CCT2 CCT3 CCT4 CCT6A CCT7 CKAP4 CS CTPS1 DDX3X DDX46 DHX9 DNAH2 DNAJA1 DST DYNC1H1 EDARADD EEF1G EEF2 EIF3A EIF3E EIF4A2 EIF4B ENO1 ENO3 EPRS1 ERO1A G3BP1 G6PD GANAB GAPDH GARS1 GDI2 GPI GTF2I HIVEP2 HMCN1 HNRNPF HSP90AA1 HSP90B1 HSPA1L HSPA5 HSPA8 HSPA9 HSPD1 HYOU1 IDH1 IPO4 IPO7 IPO9 ITPR2 KARS1 KPNA1 KPNB1 KRT18 KRT7 KRT8 KRT8P3 LRPPRC MCM7 MSN MYO18A NAP1L1 NAP1L4 NCBP1 NCL NPM1 OLA1 OXCT1 PABPC1 PCBP2 PDIA3 PDIA6 PFAS PGD PGK1 PGM1 PHGDH PKM PLOD2 PMPCA POR PPP2R1A PSMC1 PSMD2 PSMD7 PTBP1 RDX RPL6 RPSA RTCB RTN4 SARS1 SEPTIN7 SEPTIN9 SERPINH1 SFPQ SQSTM1 TARS1 TGFBI THOP1 TKT TTF2 TUBA1A TUBA8 TUBB TUBB2A TUBB3 TUBB4A TUBB4B TUBB6 TUFM TXNRD1 TYMP UBA1 VCL VCP VIM VPS35 WARS1 XPO1 XRCC5
Entrez ID		2821	202299
HPRD ID		01394	16896
Ensembl ID		ENSG00000105220	ENSG00000236882
Uniprot IDs		A0A2U3TZU2 B4DE36 P06744
PDB IDs		1IAT 1IRI 1JIQ 1JLH 1NUH 6XUH 6XUI 8BBH 8P2K 9FCW 9FHF 9FKC 9FKF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Stress BAT3 Complex Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Growth Regulation Of Growth Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Negative Regulation Of Protein Metabolic Process Dorsal/ventral Axon Guidance Spinal Cord Ventral Commissure Morphogenesis Negative Regulation Of Protein Phosphorylation Insulin-like Growth Factor Binding Protein Complex Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor Ternary Complex Negative Regulation Of Phosphorylation PCNA Complex Positive Regulation Of Deoxyribonuclease Activity PCNA-p21 Complex Replisome DNA Polymerase Processivity Factor Activity Mitotic Telomere Maintenance Via Semi-conservative Replication Dinucleotide Insertion Or Deletion Binding Leading Strand Elongation Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Positive Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Phosphate Metabolic Process Positive Regulation Of Aggrephagy Anterior/posterior Axon Guidance Negative Regulation Of Dendrite Development MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Type II Interferon-mediated Signaling Pathway Derlin-1 Retrotranslocation Complex Insulin-like Growth Factor II Binding Regulation Of DNA Repair Positive Regulation Of DNA-directed DNA Polymerase Activity Regulation Of SREBP Signaling Pathway Wnt Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Cell Death Double-strand Break Repair Via Classical Nonhomologous End Joining Apoptotic Process Rhythmic Process Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Programmed Cell Death Negative Regulation Of Collateral Sprouting	Extracellular Exosome RNA Binding Nucleotide Binding Cytosol Cytoplasm Unfolded Protein Binding ATP-dependent Protein Folding Chaperone ATP Hydrolysis Activity ATP Binding Focal Adhesion Protein Folding Secretory Granule Lumen Cadherin Binding Ficolin-1-rich Granule Lumen Protein Folding Chaperone Structural Constituent Of Cytoskeleton Nucleotide Metabolic Process Nicotinamide Nucleotide Metabolic Process Microtubule Ubiquitin Protein Ligase Binding Nucleobase-containing Compound Metabolic Process Ligase Activity Melanosome Purine Nucleotide Metabolic Process Nucleoside Phosphate Metabolic Process Protein Refolding Nucleobase-containing Small Molecule Metabolic Process Glycolytic Process Positive Regulation Of Telomerase RNA Localization To Cajal Body Ribose Phosphate Metabolic Process ADP Catabolic Process Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex ATP Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoprotein Complex Ribonucleoside Diphosphate Catabolic Process ADP Metabolic Process Nucleotide Catabolic Process Nucleoside Diphosphate Catabolic Process TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Ribonucleotide Metabolic Process Microtubule Cytoskeleton Protein Folding In Endoplasmic Reticulum Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Telomere Maintenance Via Telomerase Nucleobase-containing Compound Catabolic Process Translation TRNA Aminoacylation
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