GPI and IGFBP3

Number of citations of the paper that reports this interaction (PMID 15059907)
7

Data Source:
HPRD (in vitro)

		GPI	IGFBP3
Gene Name		glucose-6-phosphate isomerase	insulin-like growth factor binding protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Neuron Projection Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Nucleus Insulin-like Growth Factor Binding Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Glucose-6-phosphate Isomerase Activity Cytokine Activity Growth Factor Activity Intramolecular Transferase Activity Monosaccharide Binding	Fibronectin Binding Protein Binding Insulin-like Growth Factor Binding Protein Tyrosine Phosphatase Activator Activity Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Metal Ion Binding
	Biological Process	Angiogenesis Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Humoral Immune Response Hemostasis Learning Or Memory Pathogenesis Methylglyoxal Biosynthetic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Small Molecule Metabolic Process Aldehyde Catabolic Process Glucose 6-phosphate Metabolic Process	Regulation Of Cell Growth Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Protein Phosphorylation Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Signal Transduction Regulation Of Glucose Metabolic Process Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Type B Pancreatic Cell Proliferation Positive Regulation Of Myoblast Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation
Pathways		Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Glycolysis Metabolism of carbohydrates	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		Alpha-D-Glucose-6-Phosphate 6-Phosphogluconic Acid 5-Phospho-D-Arabinohydroxamic Acid Sorbitol 6-phosphate 5-Phosphoarabinonic Acid Glucose-6-Phosphate Erythose-4-Phosphate Fructose-6-Phosphate	Mecasermin
Diseases
GWAS			Insulin-like growth factors ( 21216879) Major depressive disorder ( 23377640) Ventricular conduction ( 21076409)
Protein-Protein Interactions		5 interactors: AMFR CSNK2A1 IGFBP3 PARP14 PCNA	28 interactors: ADAM12 CAV1 CD44 COL1A1 CSNK2A1 CTSD CTSG CTSL F2 FN1 GPI GTF3C1 IGF1 IGF1R IGF2 IGFALS KLK3 KLKB1 KPNB1 LTBP1 MMP1 MMP2 MMP3 PAPPA2 PLG POLA2 RXRA TF
Entrez ID		2821	3486
HPRD ID		01394	00899
Ensembl ID		ENSG00000105220	ENSG00000146674
Uniprot IDs		P06744	B3KPF0 B3KWK7 P17936
PDB IDs		1IAT 1IRI 1JIQ 1JLH 1NUH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Deoxyribonuclease Activity Leading Strand Elongation	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Hemostasis Blood Coagulation Regulation Of Body Fluid Levels Wound Healing Response To Wounding Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Regulation Of Fibrinolysis Platelet Activation Leukocyte Migration Positive Regulation Of Fibrinolysis Platelet Degranulation Response To Stimulus Proteolysis Fibrinolysis Exocrine Pancreas Development Regulation Of Blood Coagulation Response To Stress Regulation Of Protein Metabolic Process Regulation Of Wound Healing Negative Regulation Of Blood Coagulation Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Negative Regulation Of Coagulation Anatomical Structure Morphogenesis Blood Coagulation, Intrinsic Pathway Negative Regulation Of Wound Healing Prostate Gland Development Organ Morphogenesis Acute Inflammatory Response Vasculature Development Immune System Process Movement Of Cell Or Subcellular Component Factor XII Activation Cardiovascular System Development Metabolic Process Regulation Of Cellular Component Organization Regulation Of Protein Processing Locomotion Cell Activation Regulation Of Mitotic Nuclear Division Prostate Gland Epithelium Morphogenesis Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitotic Nuclear Division Prostate Gland Morphogenesis
Tagcloud ?		3h anchor anchored autoantibodies biosynthetic clone cytofluorimetry ecd ethanolamine existence full glycosylphosphatidylinositol immunoblotting inside internally mr pass phospholipase polypeptide radioligand retains sera smallest solely tail thyrotrophin transmembrane tsh tshr	bioavailability bioavailable breast circulating clinically correlation ectopic epithelium expansion igf1 igfr inducer majority mammary mitosis modulated oestradiol oestrogen possibly postulated shown specimens status stimulate stimulating synergize upregulate xenografts
Tagcloud (Difference) ?		3h anchor anchored autoantibodies biosynthetic clone cytofluorimetry ecd ethanolamine existence full glycosylphosphatidylinositol immunoblotting inside internally mr pass phospholipase polypeptide radioligand retains sera smallest solely tail thyrotrophin transmembrane tsh tshr	bioavailability bioavailable breast circulating clinically correlation ectopic epithelium expansion igf1 igfr inducer majority mammary mitosis modulated oestradiol oestrogen possibly postulated shown specimens status stimulate stimulating synergize upregulate xenografts
Tagcloud (Intersection) ?