SKA2 and SKA1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		SKA2	SKA1
Description		spindle and kinetochore associated complex subunit 2	spindle and kinetochore associated complex subunit 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Meiotic Spindle SKA Complex	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Cilium Microtubule Cytoskeleton Centriolar Satellite Ciliary Basal Body Intercellular Bridge Mitotic Spindle SKA Complex Mitotic Spindle Microtubule
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding Microtubule Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Spindle Assembly Involved In Female Meiosis Chromosome Segregation Mitotic Metaphase Chromosome Alignment Regulation Of Microtubule Polymerization Or Depolymerization Establishment Of Meiotic Spindle Orientation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Nuclear Division Spindle Assembly Involved In Female Meiosis Chromosome Segregation Mitotic Metaphase Chromosome Alignment Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Microtubule Polymerization Establishment Of Meiotic Spindle Orientation Cell Division Metaphase Chromosome Alignment Attachment Of Mitotic Spindle Microtubules To Kinetochore Establishment Of Localization In Cell Establishment Of Organelle Localization Nuclear Chromosome Segregation Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Cognitive function ( 25644384) Refractive error ( 32231278) Testicular germ cell tumor ( 23666239)	Itch intensity from mosquito bite adjusted by bite size ( 28199695) Large HDL particle concentration ( 29084231) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231)
Interacting Genes		5 interacting genes: HMOX2 IFT57 PRKD3 SKA1 SPC24	12 interacting genes: AURKB BLOC1S6 CCDC196 CCDC197 FAM9C NDC80 PSMC5 SKA2 SNAPIN SPC24 SSC5D SYCE1
Entrez ID		348235	220134
HPRD ID		13306	12689
Ensembl ID		ENSG00000182628	ENSG00000154839
Uniprot IDs		J3KSP0 Q8WVK7	Q96BD8
PDB IDs		4AJ5	4AJ5 4C9Y 4CA0
Enriched GO Terms of Interacting Partners?		Outer Kinetochore Ciliary Basal Body Attachment Of Spindle Microtubules To Kinetochore Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Heme Oxidation Heme Oxygenase (decyclizing) Activity Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Segregation Chromosome Segregation Regulation Of Nuclear Division Chromosome, Centromeric Region Kinetochore SKA Complex Ndc80 Complex Establishment Of Meiotic Spindle Orientation Dendrite Terminus Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Chromosome Organization Microtubule Binding Establishment Of Meiotic Spindle Localization Negative Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Sister Chromatid Segregation Heme Catabolic Process Porphyrin-containing Compound Catabolic Process Spindle Assembly Involved In Female Meiosis Left/right Pattern Formation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Meiotic Spindle Assembly Mitotic Spindle Microtubule Diacylglycerol-dependent Serine/threonine Kinase Activity Intraciliary Anterograde Transport Intraciliary Transport Particle B Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Keratinocyte Proliferation Regulation Of Cell Cycle Phase Transition Cell Division Meiotic Spindle Organization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Attachment Of Mitotic Spindle Microtubules To Kinetochore Keratinocyte Proliferation Negative Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Chromosome Separation	Attachment Of Spindle Microtubules To Kinetochore Attachment Of Mitotic Spindle Microtubules To Kinetochore Outer Kinetochore Ndc80 Complex Chromosome, Centromeric Region Kinetochore Cell Division Regulation Of Mitotic Sister Chromatid Separation Microvesicle Regulation Of Chromosome Separation Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Spindle Assembly Involved In Female Meiosis Establishment Of Organelle Localization Regulation Of Mitotic Metaphase/anaphase Transition Spindle Assembly Meiotic Spindle Assembly BLOC-1 Complex Regulation Of Sister Chromatid Segregation Regulation Of Mitotic Nuclear Division Chromosome Positive Regulation Of Cell Cycle Checkpoint Anterograde Synaptic Vesicle Transport Regulation Of Chromosome Segregation Regulation Of Nuclear Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Cell Cycle Chromosome Segregation Meiotic Spindle Organization Synaptonemal Complex Microtubule-based Process Spindle Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Spindle Assembly Checkpoint Signaling Organelle Localization Negative Regulation Of Mitotic Metaphase/anaphase Transition Synaptic Vesicle Transport Mitotic Sister Chromatid Segregation Melanosome Organization Pigment Granule Organization Negative Regulation Of Mitotic Nuclear Division Sister Chromatid Segregation Negative Regulation Of Mitotic Cell Cycle Spindle Microtubule Establishment Of Spindle Orientation Anterograde Axonal Transport Vesicle Transport Along Microtubule Negative Regulation Of Cell Cycle Phase Transition Regulation Of Chromosome Organization Nuclear Chromosome Segregation Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore
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