SKA2 and SPC24

Number of citations of the paper that reports this interaction (PubMedID 22371557)
46

Data Source:
BioGRID (two hybrid)

		SKA2	SPC24
Description		spindle and kinetochore associated complex subunit 2	SPC24 component of NDC80 kinetochore complex
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Meiotic Spindle SKA Complex	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytosol Ndc80 Complex
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding Microtubule Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Spindle Assembly Involved In Female Meiosis Chromosome Segregation Mitotic Metaphase Chromosome Alignment Regulation Of Microtubule Polymerization Or Depolymerization Establishment Of Meiotic Spindle Orientation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore	Chromosome Segregation Mitotic Spindle Assembly Checkpoint Signaling Attachment Of Spindle Microtubules To Kinetochore Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Cognitive function ( 25644384) Refractive error ( 32231278) Testicular germ cell tumor ( 23666239)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Coronary artery disease ( 33020668) Cortisol levels (saliva) ( 28843169) Haemorrhoidal disease ( 33888516) HDL cholesterol ( 23505323) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29617998) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 30718733) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 31095298)
Interacting Genes		5 interacting genes: HMOX2 IFT57 PRKD3 SKA1 SPC24	7 interacting genes: APP PSEN2 SKA1 SKA2 SKA3 SUOX WHRN
Entrez ID		348235	147841
HPRD ID		13306	15464
Ensembl ID		ENSG00000182628	ENSG00000161888
Uniprot IDs		J3KSP0 Q8WVK7	Q8NBT2
PDB IDs		4AJ5	2VE7 3IZ0 8PPR 8Q5H
Enriched GO Terms of Interacting Partners?		Outer Kinetochore Ciliary Basal Body Attachment Of Spindle Microtubules To Kinetochore Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Heme Oxidation Heme Oxygenase (decyclizing) Activity Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Segregation Chromosome Segregation Regulation Of Nuclear Division Chromosome, Centromeric Region Kinetochore SKA Complex Ndc80 Complex Establishment Of Meiotic Spindle Orientation Dendrite Terminus Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Chromosome Organization Microtubule Binding Establishment Of Meiotic Spindle Localization Negative Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Sister Chromatid Segregation Heme Catabolic Process Porphyrin-containing Compound Catabolic Process Spindle Assembly Involved In Female Meiosis Left/right Pattern Formation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Meiotic Spindle Assembly Mitotic Spindle Microtubule Diacylglycerol-dependent Serine/threonine Kinase Activity Intraciliary Anterograde Transport Intraciliary Transport Particle B Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Keratinocyte Proliferation Regulation Of Cell Cycle Phase Transition Cell Division Meiotic Spindle Organization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Attachment Of Mitotic Spindle Microtubules To Kinetochore Keratinocyte Proliferation Negative Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Chromosome Separation	SKA Complex Establishment Of Meiotic Spindle Orientation Establishment Of Meiotic Spindle Localization Spindle Assembly Involved In Female Meiosis Meiotic Spindle Assembly Outer Kinetochore Attachment Of Mitotic Spindle Microtubules To Kinetochore Meiotic Spindle Organization Kinetochore Mitotic Sister Chromatid Segregation Attachment Of Spindle Microtubules To Kinetochore Sister Chromatid Segregation Spindle Microtubule Establishment Of Spindle Orientation Mitotic Metaphase Chromosome Alignment Nuclear Chromosome Segregation Establishment Of Spindle Localization Metaphase Chromosome Alignment Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Spindle Localization Chromosome Localization Positive Regulation Of Mitotic Sister Chromatid Segregation Spindle Assembly Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Mitotic Cell Cycle Meiotic Spindle Organelle Localization Chromosome Segregation Mitotic Cell Cycle Positive Regulation Of Mitotic Metaphase/anaphase Transition Spindle Organization Chromosome, Centromeric Region Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Separation Spindle Establishment Of Localization In Cell Microtubule Binding Regulation Of Microtubule-based Process Establishment Of Organelle Localization Membraneless Organelle Assembly Microtubule-based Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Cell Cycle Chromosome Organization Microtubule Regulation Of Mitotic Sister Chromatid Separation Synaptic Membrane
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