SKA2 and SPC24

Number of citations of the paper that reports this interaction (PMID 22371557)
17

Data Source:
BioGRID (two hybrid)

		SKA2	SPC24
Gene Name		spindle and kinetochore associated complex subunit 2	SPC24, NDC80 kinetochore complex component
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Gene Ontology Annotations	Cellular Component	Condensed Chromosome Outer Kinetochore Cytosol Spindle Microtubule	Condensed Chromosome Kinetochore Nucleus Nucleolus Cytosol Ndc80 Complex
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Regulation Of Microtubule Polymerization Or Depolymerization Cell Division	Mitotic Cell Cycle Mitotic Nuclear Division Cell Division
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Testicular germ cell tumor ( 23666239)	HDL cholesterol ( 23505323)
Protein-Protein Interactions		4 interactors: HMOX2 PRKD3 SKA1 SPC24	5 interactors: APP PSEN2 SKA1 SKA2 SKA3
Entrez ID		348235	147841
HPRD ID		13306	15464
Ensembl ID		ENSG00000182628
Uniprot IDs		J3QKN8 Q8WVK7	B4DZZ7 Q8NBT2
PDB IDs		4AJ5	2VE7 3IZ0
Enriched GO Terms of Interacting Partners?		Heme Oxidation Mitotic Nuclear Division Heme Catabolic Process Cell Division Mitotic Cell Cycle Process Mitotic Cell Cycle Heme Metabolic Process Porphyrin-containing Compound Metabolic Process Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway	Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Chromosome Segregation Regulation Of Epidermal Growth Factor-activated Receptor Activity Endoplasmic Reticulum Calcium Ion Homeostasis Mitotic Nuclear Division Cell Division Regulation Of Protein Tyrosine Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cytoskeleton Organization Regulation Of ERBB Signaling Pathway Regulation Of Cellular Component Organization Mitotic Cell Cycle Process Regulation Of Receptor Activity Mitotic Cell Cycle Notch Signaling Pathway Regulation Of Protein Binding Synaptic Growth At Neuromuscular Junction Regulation Of Organelle Organization Collateral Sprouting In Absence Of Injury Regulation Of Peptidyl-tyrosine Phosphorylation Cell Cycle Process Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Learning Or Memory Axon Choice Point Recognition Cognition Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cell Cycle Neuron Remodeling Amyloid Precursor Protein Catabolic Process Axon Guidance Regulation Of Cellular Amino Acid Metabolic Process Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Forebrain Development Cellular Ion Homeostasis Single-organism Behavior Membrane Protein Intracellular Domain Proteolysis Metal Ion Homeostasis Cellular Copper Ion Homeostasis Membrane Protein Ectodomain Proteolysis Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cellular Ketone Metabolic Process
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