SKA2 and IFT57

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SKA2	IFT57
Description		spindle and kinetochore associated complex subunit 2	intraflagellar transport 57
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Outer Kinetochore Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Meiotic Spindle SKA Complex	Cytoplasm Golgi Apparatus Centrosome Microtubule Organizing Center Cytoskeleton Cilium Axoneme Intraciliary Transport Particle B Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Dendrite Terminus Ciliary Tip Ciliary Base
	Molecular Function	Protein Binding Microtubule Binding	DNA Binding Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Spindle Assembly Involved In Female Meiosis Chromosome Segregation Mitotic Metaphase Chromosome Alignment Regulation Of Microtubule Polymerization Or Depolymerization Establishment Of Meiotic Spindle Orientation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore	Neural Tube Closure Heart Looping Apoptotic Process Smoothened Signaling Pathway Negative Regulation Of Keratinocyte Proliferation Intraciliary Anterograde Transport Intraciliary Transport Regulation Of Apoptotic Process Keratinocyte Proliferation Motile Cilium Assembly Cilium Assembly Left/right Pattern Formation Non-motile Cilium Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Hedgehog 'off' state Intraflagellar transport Intraflagellar transport
Drugs
Diseases
GWAS		Cognitive function ( 25644384) Refractive error ( 32231278) Testicular germ cell tumor ( 23666239)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Bipolar disorder ( 31043756) Regular attendance at a religious group ( 29970889)
Interacting Genes		5 interacting genes: HMOX2 IFT57 PRKD3 SKA1 SPC24	8 interacting genes: EXOC5 HIP1 IFT20 SKA2 UBXN10 WASHC1 YAF2 ZDHHC17
Entrez ID		348235	55081
HPRD ID		13306	09430
Ensembl ID		ENSG00000182628	ENSG00000114446
Uniprot IDs		J3KSP0 Q8WVK7	Q9NWB7
PDB IDs		4AJ5
Enriched GO Terms of Interacting Partners?		Outer Kinetochore Ciliary Basal Body Attachment Of Spindle Microtubules To Kinetochore Regulation Of Mitotic Sister Chromatid Separation Regulation Of Chromosome Separation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Sister Chromatid Segregation Heme Oxidation Heme Oxygenase (decyclizing) Activity Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Segregation Chromosome Segregation Regulation Of Nuclear Division Chromosome, Centromeric Region Kinetochore SKA Complex Ndc80 Complex Establishment Of Meiotic Spindle Orientation Dendrite Terminus Negative Regulation Of Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Chromosome Organization Microtubule Binding Establishment Of Meiotic Spindle Localization Negative Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Sister Chromatid Segregation Heme Catabolic Process Porphyrin-containing Compound Catabolic Process Spindle Assembly Involved In Female Meiosis Left/right Pattern Formation Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Cell Cycle Meiotic Spindle Assembly Mitotic Spindle Microtubule Diacylglycerol-dependent Serine/threonine Kinase Activity Intraciliary Anterograde Transport Intraciliary Transport Particle B Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Keratinocyte Proliferation Regulation Of Cell Cycle Phase Transition Cell Division Meiotic Spindle Organization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Attachment Of Mitotic Spindle Microtubules To Kinetochore Keratinocyte Proliferation Negative Regulation Of Mitotic Metaphase/anaphase Transition Mitotic Spindle Assembly Checkpoint Signaling Regulation Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Chromosome Separation	Protein Transport Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Establishment Of Protein Localization Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Intracellular Protein Localization Cytoplasmic Vesicle Exocyst Cellular Localization Establishment Of Localization In Cell Intraciliary Transport Particle B Clathrin Coat Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Establishment Of Planar Polarity Organelle Assembly Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Intracellular Transport Centriole Cytoplasmic Vesicle Membrane Positive Regulation Of Cilium Assembly Cytoskeleton Regulation Of Cell Projection Assembly Establishment Of Spindle Orientation Phosphate:proton Symporter Activity Mitochondrial Phosphate Ion Transmembrane Transport TERT-RMRP Complex Template-free RNA Nucleotidyltransferase Positive Regulation Of Transdifferentiation RNA-directed RNA Polymerase Complex SiRNA Transcription Perforant Pathway To Dendrate Granule Cell Synapse Establishment Of Spindle Localization Spindle Localization Cilium Assembly Cellular Component Assembly Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Presynaptic Endocytic Zone Membrane Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Hair Cycle Telomerase Catalytic Core Complex Cilium Organization Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Opsin Transport Intraciliary Transport Particle Regulation Of Receptor Internalization Vesicle-mediated Transport Regulation Of Cellular Component Organization Clathrin-coated Vesicle Autophagosome
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