IFNA1 and IRF9

Number of citations of the paper that reports this interaction (PMID 8454630)
25

Data Source:
HPRD (in vitro)

		IFNA1	IRF9
Gene Name		interferon, alpha 1	interferon regulatory factor 9
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Cytokine Activity Type I Interferon Receptor Binding	Regulatory Region DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Humoral Immune Response Blood Coagulation Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein B Cell Proliferation Response To Exogenous DsRNA Innate Immune Response Regulation Of MHC Class I Biosynthetic Process Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Type I Interferon Biosynthetic Process Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Regulation of IFNA signaling Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production Innate Immune System	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CR2 IFNAR1 IL2 IRF9	19 interactors: ARID3B DACH2 DMRTC2 HOXC9 IFNA1 IRF1 IRF2BP1 MYO1F NFKB1 NR2E3 POU2F1 RELA S100A13 STAT1 STAT2 TLX2 TLX3 TOP1 VENTX
Entrez ID		3439	10379
HPRD ID		00974	00960
Ensembl ID		ENSG00000197919	ENSG00000213928
Uniprot IDs		L0N195 P01562	Q00978
PDB IDs		3UX9
Enriched GO Terms of Interacting Partners?		Type I Interferon Biosynthetic Process Type I Interferon Production Cytokine Biosynthetic Process Immune Response Cytokine Metabolic Process Lymphocyte Activation Positive Regulation Of Interferon-gamma Production Leukocyte Activation Immune System Process Regulation Of Interferon-gamma Production Cell Activation Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Innate Immune Response Regulation Of Immune Response Cytokine Production Defense Response To Virus Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Secretion Regulation Of T Cell Homeostatic Proliferation Lymphocyte Differentiation Regulation Of Immune System Process Defense Response Response To Virus Complement Receptor Mediated Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Positive Regulation Of Regulatory T Cell Differentiation Leukocyte Cell-cell Adhesion Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Secretion Homotypic Cell-cell Adhesion Leukocyte Differentiation Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Positive Regulation Of Immunoglobulin Secretion Regulation Of Isotype Switching To IgG Isotypes Regulation Of Protein Secretion Positive Regulation Of Interleukin-17 Production Negative Regulation Of B Cell Apoptotic Process Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Immunoglobulin Secretion Single Organismal Cell-cell Adhesion Regulation Of Cytokine Production Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Regulation Of B Cell Apoptotic Process	Regulation Of Innate Immune Response Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Regulation Of Interleukin-12 Biosynthetic Process RNA Metabolic Process Defense Response To Virus Gene Expression Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Other Organism Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Response To Biotic Stimulus Cellular Nitrogen Compound Metabolic Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Virus Response To Type I Interferon Regulation Of Immune Response Transcription From RNA Polymerase II Promoter Immune Response Cellular Response To Cytokine Stimulus Nitrogen Compound Metabolic Process Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Response To Cytokine Regulation Of Interleukin-12 Production Cellular Response To Nicotine Cytokine-mediated Signaling Pathway Response To Mechanical Stimulus Innate Immune Response Positive Regulation Of Type I Interferon Production Developmental Process Regulation Of MiRNA Metabolic Process Response To External Stimulus Regulation Of Immune System Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Positive Regulation Of Transcription, DNA-templated
Tagcloud ?		adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifngr1 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted	antiviral attenuated defense enhancement essential failed guanylate iav ifn impaired induces inducible infection influenza interference interferon isg15 isg20 isgs knockdown knocked oligoadenylate p53 pretreatment replication retinoic secretion synthetase
Tagcloud (Difference) ?		adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifngr1 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted	antiviral attenuated defense enhancement essential failed guanylate iav ifn impaired induces inducible infection influenza interference interferon isg15 isg20 isgs knockdown knocked oligoadenylate p53 pretreatment replication retinoic secretion synthetase
Tagcloud (Intersection) ?