IRF9 and NR2E3

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		IRF9	NR2E3
Description		interferon regulatory factor 9	nuclear receptor subfamily 2 group E member 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol ISGF3 Complex	Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Signal Transduction Visual Perception Phototransduction Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Neuron Differentiation Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Eye Photoreceptor Cell Development Positive Regulation Of Transcription By RNA Polymerase II Retina Development In Camera-type Eye
Pathways		Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases			Retinitis pigmentosa (RP) Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS			Hematocrit ( 32888494) Hemoglobin ( 32888494) Macular thickness ( 30535121) Metabolite levels (HVA/MHPG ratio) ( 23319000) Red blood cell count ( 32888494)
Interacting Genes		20 interacting genes: ARID3B DACH2 DMRTC2 HOXC9 IFNA1 ILF3 IRF1 IRF2BP1 MYO1F NFKB1 NR2E3 POU2F1 RELA S100A13 STAT1 STAT2 TLX2 TLX3 TOP1 VENTX	29 interacting genes: BCL11A CDK9 CRX DEDD2 DHX30 ELAVL2 HDAC1 HDAC3 HOXC13 IRF9 MYBBP1A NCOR1 NR1D1 NR3C1 NRL POLR3D PPARG RARA RBBP4 RBBP7 RBFOX2 RBL1 RXRA RXRB SIN3A SNAPC1 TBL3 WDR5 ZNF232
Entrez ID		10379	10002
HPRD ID		00960	05132
Ensembl ID		ENSG00000213928	ENSG00000278570
Uniprot IDs		A0A8V8TMJ8 A0A8V8TP83 H0YNP4 Q00978	F1D8Q9 Q9Y5X4
PDB IDs			4LOG
Enriched GO Terms of Interacting Partners?		DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Response To Virus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Nucleus Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process Defense Response To Virus Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process NF-kappaB P50/p65 Complex Interferon-mediated Signaling Pathway RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Nucleoplasm ISGF3 Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cytokine-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of RNA Metabolic Process Response To Peptide Hormone Transcription Coactivator Binding Type I Interferon-mediated Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Nicotine Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Interleukin-12 Production Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Response To Mechanical Stimulus Actinin Binding DNA-templated Transcription Type II Interferon-mediated Signaling Pathway	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Cis-regulatory Region Binding Nucleus Positive Regulation Of RNA Metabolic Process Histone Deacetylase Complex Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Chromatin Binding Hormone-mediated Signaling Pathway DNA-binding Transcription Factor Activity Negative Regulation Of Macromolecule Metabolic Process Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Sin3-type Complex Chromatin Organization Retinoic Acid Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Metabolic Process Retinoic Acid-responsive Element Binding Nucleic Acid Metabolic Process
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