IFNA1 and IL2

Number of citations: 0 (PubMedID 3262520)
Data Source: HPRD (in vitro)

		IFNA1	IL2
Name		interferon alpha 1	interleukin 2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Type I Interferon Receptor Binding Protein Binding	Cytokine Activity Interleukin-2 Receptor Binding Protein Binding Growth Factor Activity Kinase Activator Activity Carbohydrate Binding Kappa-type Opioid Receptor Binding Glycosphingolipid Binding
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Defense Response Humoral Immune Response Response To Exogenous DsRNA Symbiont Entry Into Host Cell Defense Response To Virus Type I Interferon-mediated Signaling Pathway Cellular Response To Virus Antiviral Innate Immune Response	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Immune System Process Positive Regulation Of Immunoglobulin Production Negative Regulation Of B Cell Apoptotic Process Transcription By RNA Polymerase II Immune Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Gene Expression Natural Killer Cell Activation T Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tissue Remodeling Interleukin-2-mediated Signaling Pathway T Cell Proliferation Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation Lymphocyte Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Activated T Cell Proliferation Positive Regulation Of Dendritic Spine Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Plasma Cell Differentiation Response To Tacrolimus Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling TRAF6 mediated IRF7 activation SARS-CoV-2 activates/modulates innate and adaptive immune responses Factors involved in megakaryocyte development and platelet production Evasion by RSV of host interferon responses	RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs		None	Pseudoephedrine Cefazolin SP4160 N(2)-carbamimidoyl-N-{2-[4-(3-{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl}-D-leucinamide 3-Mercapto-1-(1,3,4,9-Tetrahydro-B-Carbolin-2-Yl)-Propan-1-One Methyl (2S)-2-[[2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate (1H-indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid SP2456 2-[2-(2-Cyclohexyl-2-guanidino-acetylamino)-acetylamino]-N-(3-mercapto-propyl)-propionamide Keyhole limpet hemocyanin Girentuximab TG4010
Diseases		None	Graft-versus-host disease Type I diabetes mellitus
GWAS		No GWAS studies recorded	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406 ) Allergic rhinitis ( 30013184 ) Allergic sensitization ( 30013184 23817571 ) Allergy ( 27182965 ) Alopecia areata ( 25608926 20596022 ) Asthma ( 31619474 31361310 31959851 30929738 ) Asthma (adult onset) ( 30929738 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 30929738 31036433 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atopic dermatitis ( 25574825 23727859 26482879 ) Bipolar disorder ( 31043756 ) Celiac disease ( 24999842 25920553 22057235 20190752 17558408 18311140 ) Crohn's disease ( 28067908 ) Eosinophil count ( 32888494 ) IgE grass sensitization ( 22036096 ) Inflammatory bowel disease ( 28067908 23128233 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Medication use (adrenergics, inhalants) ( 31015401 ) Primary sclerosing cholangitis ( 27992413 23603763 ) Progressive supranuclear palsy ( 21685912 ) Rheumatoid arthritis ( 30423114 24390342 ) Selective IgA deficiency ( 27723758 ) Systemic lupus erythematosus ( 28714469 ) Type 1 diabetes ( 19430480 21829393 25751624 ) Ulcerative colitis ( 21297633 ) Vaso-occlusive pain in sickle-cell anemia ( 28584135 )
Novel Interactors		1 novel interactors: GLDC	1 novel interactors: FGF2
Interacting Genes		4 interacting genes: CR2 IFNAR1 IL2 IRF9	9 interacting genes: CD53 FOXK2 IFNA1 IL2RA IL2RB IL2RG NGFR S100A6 SHC1
Entrez ID		3439	3558
HPRD ID		00974	00979
Ensembl ID		ENSG00000197919	ENSG00000109471
Uniprot IDs		L0N195 P01562	P60568 Q0GK43
PDB IDs		3UX9	1IRL 1M47 1M48 1M49 1M4A 1M4B 1M4C 1NBP 1PW6 1PY2 1QVN 1Z92 2B5I 2ERJ 3INK 3QAZ 3QB1 4NEJ 4NEM 5LQB 5M5E 5UTZ 6LX3 6LXW 6VWU 6YE3 7DR4 7M2G 7RA9 7RAA 7YZJ 7ZMZ 8SOW 8SOZ 8WYR 8WYS
GO Terms Enriched among Interactors		Type I Interferon-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Response To Virus Interferon-mediated Signaling Pathway Negative Regulation Of Adaptive Immune Response Glycine Dehydrogenase (decarboxylating) Activity Pyridoxal Binding Response To Methylamine Cell Surface Receptor Signaling Pathway Via STAT Kappa-type Opioid Receptor Binding Lymphocyte Proliferation Leukocyte Proliferation Cell Surface Receptor Signaling Pathway Mononuclear Cell Proliferation Glycine Decarboxylation Via Glycine Cleavage System Response To Lipoic Acid Glycine Cleavage Complex Glycine Catabolic Process Type I Interferon Receptor Activity Type I Interferon Binding JAK Pathway Signal Transduction Adaptor Activity Interferon Receptor Activity Regulation Of T Cell Homeostatic Proliferation Response To Tacrolimus ISGF3 Complex Positive Regulation Of Plasma Cell Differentiation Receptor Complex Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Interleukin-2 Receptor Binding Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Glycosphingolipid Binding Complement Binding Negative Regulation Of Complement Activation, Classical Pathway Lymphocyte Differentiation Complement Receptor Activity Response To Other Organism Activated T Cell Proliferation Adaptive Immune Response Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Defense Response To Virus Glycine Binding Cellular Response To Interferon-alpha Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Response To External Biotic Stimulus Negative Regulation Of Complement Activation Mononuclear Cell Differentiation Complement Receptor Mediated Signaling Pathway	Interleukin-2 Binding Interleukin-2 Receptor Activity Interleukin-2-mediated Signaling Pathway Interleukin-2 Receptor Complex Interleukin-15 Receptor Activity Cell Surface Receptor Signaling Pathway Coreceptor Activity Interleukin-15-mediated Signaling Pathway Signal Transduction Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cell Surface Cytokine Receptor Activity Positive Regulation Of Developmental Process Positive Regulation Of MiRNA Transcription Positive Regulation Of Fibroblast Proliferation Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway T Cell Activation Positive Regulation Of MiRNA Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Regulation Of Animal Organ Morphogenesis Response To Wortmannin Positive Regulation Of Inner Ear Receptor Cell Differentiation Regulation Of MiRNA Transcription Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Activation External Side Of Plasma Membrane Positive Regulation Of Phagocytosis Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Intracellular Glucose Homeostasis Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Dorsal Aorta Development Shc-EGFR Complex Regulation Of MiRNA Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Angiogenesis Involved In Coronary Vascular Morphogenesis Regulation Of Retinal Cell Programmed Cell Death Lymphatic Endothelial Cell Migration Positive Regulation Of Cell Development Corticotropin Hormone Secreting Cell Differentiation