IFNA1 and CR2

Number of citations: 46 (PubMedID 1849076)
Data Source: HPRD (in vivo)

		IFNA1	CR2
Name		interferon alpha 1	complement C3d receptor 2
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space Plasma Membrane Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Cytokine Activity Cytokine Receptor Binding Type I Interferon Receptor Binding Protein Binding	Virus Receptor Activity Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Immunoglobulin Receptor Binding Protein Homodimerization Activity
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response B Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Defense Response Humoral Immune Response Response To Exogenous DsRNA Symbiont Entry Into Host Cell Defense Response To Virus Type I Interferon-mediated Signaling Pathway Cellular Response To Virus Antiviral Innate Immune Response	Immune System Process Complement Receptor Mediated Signaling Pathway T Cell Mediated Immunity Immune Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway B Cell Differentiation B Cell Proliferation B Cell Activation Innate Immune Response Negative Regulation Of Complement Activation, Classical Pathway Symbiont Entry Into Host Cell Type I Interferon-mediated Signaling Pathway Antiviral Innate Immune Response
Pathways		Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling TRAF6 mediated IRF7 activation SARS-CoV-2 activates/modulates innate and adaptive immune responses Factors involved in megakaryocyte development and platelet production Evasion by RSV of host interferon responses	Regulation of Complement cascade
GWAS		No GWAS studies recorded	Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717 ) Refractive error ( 32231278 ) Systemic sclerosis ( 29293537 ) Type 2 diabetes ( 21490949 )
Interacting Genes		4 interacting genes: CR2 IFNAR1 IL2 IRF9	11 interacting genes: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 NCOA1 TP53
Entrez ID		3439	1380
HPRD ID		00974	00399
Ensembl ID		ENSG00000197919	ENSG00000117322
Uniprot IDs		L0N195 P01562	P20023
PDB IDs		3UX9	1GHQ 1LY2 1W2R 1W2S 2ATY 2GSX 3OED 8SM0 8ZNI
GO Terms Enriched among Interactors		Type I Interferon-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Response To Virus Interferon-mediated Signaling Pathway Negative Regulation Of Adaptive Immune Response Glycine Dehydrogenase (decarboxylating) Activity Pyridoxal Binding Response To Methylamine Cell Surface Receptor Signaling Pathway Via STAT Kappa-type Opioid Receptor Binding Lymphocyte Proliferation Leukocyte Proliferation Cell Surface Receptor Signaling Pathway Mononuclear Cell Proliferation Glycine Decarboxylation Via Glycine Cleavage System Response To Lipoic Acid Glycine Cleavage Complex Glycine Catabolic Process Type I Interferon Receptor Activity Type I Interferon Binding JAK Pathway Signal Transduction Adaptor Activity Interferon Receptor Activity Regulation Of T Cell Homeostatic Proliferation Response To Tacrolimus ISGF3 Complex Positive Regulation Of Plasma Cell Differentiation Receptor Complex Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Interleukin-2 Receptor Binding Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Glycosphingolipid Binding Complement Binding Negative Regulation Of Complement Activation, Classical Pathway Lymphocyte Differentiation Complement Receptor Activity Response To Other Organism Activated T Cell Proliferation Adaptive Immune Response Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Defense Response To Virus Glycine Binding Cellular Response To Interferon-alpha Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes Response To External Biotic Stimulus Negative Regulation Of Complement Activation Mononuclear Cell Differentiation Complement Receptor Mediated Signaling Pathway	Immune Effector Process Positive Regulation Of Humoral Immune Response Positive Regulation Of Activation Of Membrane Attack Complex Regulation Of Humoral Immune Response Protein-containing Complex Positive Regulation Of Complement Activation Interferon-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Leukocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Activation Complement Receptor Mediated Signaling Pathway Complement Activation, Alternative Pathway Immune Response Immune System Process Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Immune Response-activating Signaling Pathway Lymphocyte Activation Involved In Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Complement Activation Immune Response-regulating Signaling Pathway Activation Of Immune Response Leukocyte Activation Involved In Immune Response Signal Transduction Cell Activation Involved In Immune Response Negative Regulation Of Catalytic Activity Lymphocyte Activation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Regulation Of ATP-dependent Activity B Cell Activation Complement Activation, Classical Pathway Regulation Of Lymphocyte Mediated Immunity Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Telomere Maintenance Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Adaptive Immune Response Regulation Of Telomere Maintenance Via Telomerase Response To Other Organism Positive Regulation Of Immune Response Positive Regulation Of Immune Effector Process Innate Immune Response Complement Activation C5L2 Anaphylatoxin Chemotactic Receptor Binding Humoral Immune Response Complement Component C3b Receptor Activity Immune Complex Clearance By Erythrocytes Complement Component C4b Receptor Activity Negative Regulation Of Serine-type Endopeptidase Activity