IFNA1 and CR2

Number of citations of the paper that reports this interaction (PMID 1849076)
14

Data Source:
HPRD (in vivo)

		IFNA1	CR2
Gene Name		interferon, alpha 1	complement component (3d/Epstein Barr virus) receptor 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Type I Interferon Receptor Binding	Complement Binding DNA Binding Complement Receptor Activity Transmembrane Signaling Receptor Activity Protein Homodimerization Activity
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Humoral Immune Response Blood Coagulation Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein B Cell Proliferation Response To Exogenous DsRNA Innate Immune Response Regulation Of MHC Class I Biosynthetic Process Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Complement Receptor Mediated Signaling Pathway Immune Response Complement Activation, Classical Pathway B Cell Differentiation B Cell Proliferation Innate Immune Response
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Regulation of IFNA signaling Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production Innate Immune System
Drugs
Diseases
GWAS			Type 2 diabetes ( 21490949)
Protein-Protein Interactions		4 interactors: CR2 IFNAR1 IL2 IRF9	10 interactors: ANXA6 C3 CD19 CR1 FCER2 FHOD1 HNRNPU IFITM1 IFNA1 TP53
Entrez ID		3439	1380
HPRD ID		00974	00399
Ensembl ID		ENSG00000197919	ENSG00000117322
Uniprot IDs		L0N195 P01562	P20023
PDB IDs		3UX9	1GHQ 1LY2 1W2R 1W2S 2GSX 3OED
Enriched GO Terms of Interacting Partners?		Type I Interferon Biosynthetic Process Type I Interferon Production Cytokine Biosynthetic Process Immune Response Cytokine Metabolic Process Lymphocyte Activation Positive Regulation Of Interferon-gamma Production Leukocyte Activation Immune System Process Regulation Of Interferon-gamma Production Cell Activation Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Innate Immune Response Regulation Of Immune Response Cytokine Production Defense Response To Virus Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Secretion Regulation Of T Cell Homeostatic Proliferation Lymphocyte Differentiation Regulation Of Immune System Process Defense Response Response To Virus Complement Receptor Mediated Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Positive Regulation Of Regulatory T Cell Differentiation Leukocyte Cell-cell Adhesion Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Secretion Homotypic Cell-cell Adhesion Leukocyte Differentiation Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Positive Regulation Of Immunoglobulin Secretion Regulation Of Isotype Switching To IgG Isotypes Regulation Of Protein Secretion Positive Regulation Of Interleukin-17 Production Negative Regulation Of B Cell Apoptotic Process Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Immunoglobulin Secretion Single Organismal Cell-cell Adhesion Regulation Of Cytokine Production Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Regulation Of B Cell Apoptotic Process	Regulation Of Immune Response Regulation Of Humoral Immune Response Immune Response Regulation Of Immune System Process Innate Immune Response Positive Regulation Of Humoral Immune Response Cell Surface Receptor Signaling Pathway Regulation Of Adaptive Immune Response Regulation Of Complement Activation Immune System Process Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Immune Response Humoral Immune Response Defense Response Adaptive Immune Response T Cell Activation Involved In Immune Response Positive Regulation Of Immune System Process Regulation Of Acute Inflammatory Response Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Hydrolase Activity Positive Regulation Of Cellular Protein Metabolic Process B Cell Differentiation Negative Regulation Of Macromitophagy Negative Regulation Of Complement Activation, Alternative Pathway Oligodendrocyte Apoptotic Process Positive Regulation Of Type IIa Hypersensitivity Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Lymphocyte Proliferation Mononuclear Cell Proliferation Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Protein Metabolic Process Leukocyte Proliferation Negative Regulation Of Helicase Activity Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Notch Signaling Pathway Complement Activation Signal Transduction Negative Regulation Of Complement Activation, Classical Pathway Positive Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Adaptive Immune Response Leukocyte Activation Involved In Immune Response B Cell Activation Defense Response To Virus Complement Receptor Mediated Signaling Pathway CRD-mediated MRNA Stabilization Protein Activation Cascade
Tagcloud ?		adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifngr1 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted	abolish abrogated adenovirus agar cooperation cotransfected cotransformation cr1 deletions dramatically e1a e1b embryo encode exon foci hypertransformation immortalization immortalizing impacted oncogenes plasmid plasmids prb soft src synergistically transformation v
Tagcloud (Difference) ?		adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifngr1 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted	abolish abrogated adenovirus agar cooperation cotransfected cotransformation cr1 deletions dramatically e1a e1b embryo encode exon foci hypertransformation immortalization immortalizing impacted oncogenes plasmid plasmids prb soft src synergistically transformation v
Tagcloud (Intersection) ?