IFNA1

Gene Name		interferon, alpha 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Type I Interferon Receptor Binding
	Biological Process	Adaptive Immune Response T Cell Activation Involved In Immune Response Natural Killer Cell Activation Involved In Immune Response Humoral Immune Response Blood Coagulation Cytokine-mediated Signaling Pathway B Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein B Cell Proliferation Response To Exogenous DsRNA Innate Immune Response Regulation Of MHC Class I Biosynthetic Process Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Regulation of IFNA signaling Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: CR2 IFNAR1 IL2 IRF9
Entrez ID		3439
HPRD ID		00974
Ensembl ID		ENSG00000197919
Uniprot IDs		L0N195 P01562
PDB IDs		3UX9
Enriched GO Terms of Interacting Partners?		Type I Interferon Biosynthetic Process Type I Interferon Production Cytokine Biosynthetic Process Immune Response Cytokine Metabolic Process Lymphocyte Activation Positive Regulation Of Interferon-gamma Production Leukocyte Activation Immune System Process Regulation Of Interferon-gamma Production Cell Activation Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Innate Immune Response Regulation Of Immune Response Cytokine Production Defense Response To Virus Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Secretion Regulation Of T Cell Homeostatic Proliferation Lymphocyte Differentiation Regulation Of Immune System Process Defense Response Response To Virus Complement Receptor Mediated Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Positive Regulation Of Regulatory T Cell Differentiation Leukocyte Cell-cell Adhesion Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Secretion Homotypic Cell-cell Adhesion Leukocyte Differentiation Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Positive Regulation Of Immunoglobulin Secretion Regulation Of Isotype Switching To IgG Isotypes Regulation Of Protein Secretion Positive Regulation Of Interleukin-17 Production Negative Regulation Of B Cell Apoptotic Process Cytokine-mediated Signaling Pathway Signal Transduction Regulation Of Immunoglobulin Secretion Single Organismal Cell-cell Adhesion Regulation Of Cytokine Production Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Regulation Of B Cell Apoptotic Process
Tagcloud ?		adjustment altogether colorectal correction covered crc czech distant etiology formally genotyped ifna7 ifngr1 ifnk irf3 irf5 irf7 multivariable republic rs2234711 rs2856968 rs6475526 snp snps warranted