EAF2 and ELL

Number of citations: 0 (PubMedID 12446457)
Data Source: HPRD (in vivo)

		EAF2	ELL
Name		ELL associated factor 2	elongation factor for RNA polymerase II
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Elongation Factor Complex Nuclear Speck Super Elongation Complex	Euchromatin Nucleus Nucleoplasm Cytosol Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Histone Locus Body
	Molecular Function	Transcription Elongation Factor Activity Protein Binding	Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Phosphatase Binding
	Biological Process	Transcription Elongation By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Growth Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development	In Utero Embryonic Development Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II SnRNA Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase III Positive Regulation Of Transcription By RNA Polymerase III
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Transcription-Coupled Nucleotide Excision Repair (TC-NER) TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
GWAS		No GWAS studies recorded	A body shape index ( 34021172 ) Alanine aminotransferase levels ( 34315874 ) Alzheimer's disease (late onset) ( 30820047 ) Apolipoprotein A1 levels ( 32203549 ) Aspartate aminotransferase levels ( 34315874 ) Breast cancer ( 29059683 23535729 ) Coronary artery disease ( 29212778 ) HDL cholesterol levels ( 32203549 ) Iron status biomarkers (ferritin levels) ( 33536631 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 27863252 ) Mean corpuscular hemoglobin concentration ( 32888494 27863252 ) Mean corpuscular volume ( 32888494 27863252 ) Monocyte count ( 32888494 ) Pulse pressure ( 30224653 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Waist-hip index ( 34021172 )
Novel Interactors		None recorded	1 novel interactors: PRKACA
Interacting Genes		20 interacting genes: BEND7 BIRC2 ELL GOLGA2 HIF1A IHO1 LNX2 NECAB2 PNMA1 PSME3 RBPMS SSX2IP STAC3 TCEA1 TCEA2 TFIP11 TFPT TLE5 TP53 TRIM23	13 interacting genes: EAF1 EAF2 EP300 HDAC3 HNRNPU MCM2 POLR2A SNF8 TFPT TP53 UBC WEE2-AS1 ZHX1
Entrez ID		55840	8178
HPRD ID		09634	02615
Ensembl ID		ENSG00000145088	ENSG00000105656
Uniprot IDs		B4DWJ3 Q96CJ1	P55199 U3KQ90
PDB IDs		Not available	2DOA
GO Terms Enriched among Interactors		Identical Protein Binding Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation P53 Binding Regulation Of Thymocyte Apoptotic Process Cis-regulatory Region Sequence-specific DNA Binding MDM2/MDM4 Family Protein Binding Necroptotic Process Lactate Metabolic Process Neural Precursor Cell Proliferation Programmed Necrotic Cell Death Transcription Elongation Factor Complex	Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process RNA Metabolic Process Circadian Rhythm Chromatin Remodeling Transcription Elongation By RNA Polymerase II Super Elongation Complex DNA-templated Transcription Elongation Regulation Of Primary Metabolic Process Positive Regulation Of Nucleocytoplasmic Transport Transcription Elongation Factor Activity Regulation Of DNA-templated Transcription Regulation Of Carbohydrate Catabolic Process Regulation Of RNA Biosynthetic Process Nucleus Promoter-specific Chromatin Binding Chromatin Organization Cellular Response To Parathyroid Hormone Stimulus Nucleobase-containing Compound Biosynthetic Process Regulation Of Purine Nucleotide Metabolic Process Regulation Of RNA Metabolic Process Chromatin DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Intracellular Protein Transport Rhythmic Process Random Inactivation Of X Chromosome Epigenetic Regulation Of Gene Expression Regulation Of Transcription Elongation By RNA Polymerase II Response To Parathyroid Hormone Regulation Of Glucose Metabolic Process DNA Binding Regulation Of DNA-templated Transcription Elongation Ubiquitin Protein Ligase Binding Regulation Of Telomere Maintenance Regulation Of Gene Expression Negative Regulation Of Small Molecule Metabolic Process Protein Localization To Organelle Regulation Of DNA Replication Regulation Of Nucleocytoplasmic Transport Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Transcription Elongation Factor Complex Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome