EAF2 and STAC3

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		EAF2	STAC3
Description		ELL associated factor 2	SH3 and cysteine rich domain 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Elongation Factor Complex Nuclear Speck Super Elongation Complex	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Membrane T-tubule Sarcolemma Synapse
	Molecular Function	Transcription Elongation Factor Activity Protein Binding	Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Transcription Elongation By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Growth Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development	Skeletal Muscle Contraction Neuromuscular Synaptic Transmission Skeletal Muscle Fiber Development Positive Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Glycated hemoglobin levels ( 34059833) Schizophrenia ( 25056061 29483656)
Interacting Genes		20 interacting genes: BEND7 BIRC2 ELL GOLGA2 HIF1A IHO1 LNX2 NECAB2 PNMA1 PSME3 RBPMS SSX2IP STAC3 TCEA1 TCEA2 TFIP11 TFPT TLE5 TP53 TRIM23	38 interacting genes: ANKRD36 BAZ2B C1orf35 CSNK2A1 DIP2A DRC4 EAF1 EAF2 ENKD1 FAM124A FAM133A FAM90A1 FAM9A FGF11 FGF12 GIGYF1 GRB7 HMGXB4 INO80B JMJD6 L3MBTL2 MAB21L3 MFAP1 NKAPD1 NSD3 PPARA RPL22 RPL9 RPS25 SPANXN2 SPANXN3 SREK1IP1 TCEA2 TNFAIP8L1 U2AF2 VCX2 ZCCHC10 ZGPAT
Entrez ID		55840	246329
HPRD ID		09634	11606
Ensembl ID		ENSG00000145088	ENSG00000185482
Uniprot IDs		B4DWJ3 Q96CJ1	Q96MF2
PDB IDs			2DB6 6B29 6UY7 6UY8 6UY9
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation P53 Binding Regulation Of Thymocyte Apoptotic Process Cis-regulatory Region Sequence-specific DNA Binding MDM2/MDM4 Family Protein Binding Necroptotic Process Lactate Metabolic Process Neural Precursor Cell Proliferation Programmed Necrotic Cell Death Transcription Elongation Factor Complex	Transcription Elongation Factor Complex Super Elongation Complex Transcription Elongation By RNA Polymerase II Transcription Elongation Factor Activity DNA-templated Transcription Elongation Transcription Regulator Activator Activity
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