EAF2 and TCEA1

Number of citations of the paper that reports this interaction (PMID 12761297)
3

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		EAF2	TCEA1
Gene Name		ELL associated factor 2	transcription elongation factor A (SII), 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Transcription Elongation Factor Complex Nuclear Speck ELL-EAF Complex	Nucleus Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding	DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Transcription, DNA-templated Apoptotic Process Negative Regulation Of Cell Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development	DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Erythrocyte Differentiation Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription
Pathways			Nucleotide Excision Repair Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: BEND7 BIRC2 ELL TCEA1 TCEA2 TFPT TRIM23	17 interactors: APP CDC73 CDK7 CIR1 CTDP1 CTR9 EAF2 GTF2E1 GTF2F2 IWS1 LEO1 PAF1 POLR2A REXO1 RTF1 UBR5 WDR61
Entrez ID		55840	6917
HPRD ID		09634	03252
Ensembl ID		ENSG00000145088	ENSG00000187735
Uniprot IDs		B4DWJ3 Q96CJ1	B7Z4S1 P23193
PDB IDs			1TFI 3NDQ
Enriched GO Terms of Interacting Partners?		Regulation Of DNA-templated Transcription, Elongation DNA-templated Transcription, Elongation Transcription, DNA-templated Positive Regulation Of Viral Transcription RNA Biosynthetic Process Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process Viral Process RNA Metabolic Process Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Regulation Of Viral Process Translational Elongation Regulation Of Protein Monoubiquitination Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process SnRNA Transcription From RNA Polymerase III Promoter Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Transcription From RNA Polymerase II Promoter SnRNA Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Nitrogen Compound Metabolic Process SnRNA Transcription Positive Regulation Of Transcription From RNA Polymerase III Promoter Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Negative Regulation Of Necroptotic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Negative Regulation Of Necrotic Cell Death Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Negative Regulation Of Hydrolase Activity Positive Regulation Of Macromolecule Biosynthetic Process	Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation From RNA Polymerase II Promoter Endodermal Cell Fate Commitment Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription, Elongation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated MRNA Processing Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Histone H2B Ubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Cell Fate Commitment Involved In Formation Of Primary Germ Layer Positive Regulation Of Gene Expression MRNA Metabolic Process Gene Expression Positive Regulation Of Cellular Biosynthetic Process Endodermal Cell Differentiation RNA Processing Regulation Of Nitrogen Compound Metabolic Process Endoderm Formation Transcription Elongation From RNA Polymerase II Promoter Stem Cell Maintenance Regulation Of RNA Biosynthetic Process Histone Monoubiquitination Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Elongation Negative Regulation Of Myeloid Cell Differentiation Endoderm Development MRNA Polyadenylation Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Histone Ubiquitination RNA Polyadenylation Negative Regulation Of Cell Differentiation Stem Cell Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Protein Monoubiquitination Regulation Of Histone Modification Wnt Signaling Pathway Formation Of Primary Germ Layer Positive Regulation Of Viral Transcription
Tagcloud ?		aberrant aim2 bh3 bik complements constitutive cooperates diffuse dlbcl expansion forkhead foxp1 harakiri lymphoid lymphoma lymphomagenesis lymphomas mucosa next oncogene proapoptotic promote rassf6 regarded relying represses repression tp53inp1 tp63	arachnoid beforehand cdc25a cdk6 cluego cytoscape distinctive dysregulation helpful hub ifit ifit1 introduced mcm2 mcm7 mcode meningioma meningiomas meningothelial mined names neutralization ppi rbc sec31a seed subnetworks ube2e1 xrcc5
Tagcloud (Difference) ?		aberrant aim2 bh3 bik complements constitutive cooperates diffuse dlbcl expansion forkhead foxp1 harakiri lymphoid lymphoma lymphomagenesis lymphomas mucosa next oncogene proapoptotic promote rassf6 regarded relying represses repression tp53inp1 tp63	arachnoid beforehand cdc25a cdk6 cluego cytoscape distinctive dysregulation helpful hub ifit ifit1 introduced mcm2 mcm7 mcode meningioma meningiomas meningothelial mined names neutralization ppi rbc sec31a seed subnetworks ube2e1 xrcc5
Tagcloud (Intersection) ?