SMCO4 and CLEC10A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMCO4	CLEC10A
Description		single-pass membrane protein with coiled-coil domains 4	C-type lectin domain containing 10A
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Lysosome Lysosomal Membrane Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Early Endosome Membrane
	Molecular Function	Protein Binding	Protein Binding D-mannose Binding Carbohydrate Binding Pattern Recognition Receptor Activity Fucose Binding
	Biological Process		Adaptive Immune Response Immune System Process Endocytosis Immune Response Innate Immune Response
Pathways			Dectin-2 family
Drugs
Diseases
GWAS		Adult body size ( 32376654) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Liver enzyme levels (alanine transaminase) ( 33972514)	Carotid intima media thickness x smoking interaction ( 32117412) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Liver enzyme levels (alkaline phosphatase) ( 33972514) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		62 interacting genes: AQP6 ARL13B BNIP3L CD79A CLEC10A CLTRN CPLX4 CREB3L1 CXCR2 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B FFAR2 GJA8 GKN1 GPA33 GPR152 GPR42 HHLA2 ICAM3 IL10RA KASH5 KCNK5 KIR3DL1 KRT40 KRTAP10-3 KRTAP10-7 LEPROTL1 LMNA LRRC25 M6PR MGST3 MS4A3 MUC1 PEX12 PLD3 PTGES RETREG3 SCN3B SLC10A6 SLC16A2 SLC18A1 SLC35H1 SLC41A3 SLC7A1 SLC7A14 SMIM3 SPINT1 STOM SUSD3 SYNE4 SYNPR TEX29 TFEC TMEM139 TMEM80 TMX2 VSIR WBP1	26 interacting genes: ACSF2 ADIPOQ APOD BET1 C3orf52 CFTR CLN6 FMO3 FXYD6 GIMAP1 MALL NAPB PEX16 PRAF2 SEC22A SLC38A7 SMCO4 SNCA TMEM218 TNF TRARG1 TSPO UNC50 VSTM1 ZDHHC15 ZFPL1
Entrez ID		56935	10462
HPRD ID		17008	12076
Ensembl ID		ENSG00000166002	ENSG00000132514
Uniprot IDs		Q9NRQ5	J3KR22 Q8IUN9
PDB IDs			6PUV 6PY1 6W12 6XIY
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding	Membrane Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Endoplasmic Reticulum Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peripheral Nervous System Axon Regeneration Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Protein Localization To Membrane Regulation Of Lipid Metabolic Process Negative Regulation Of Secretion Cellular Response To Epinephrine Stimulus Intracellular Protein Localization Positive Regulation Of Monoatomic Ion Transport Response To Epinephrine Regulation Of Chemokine Production Negative Regulation Of Transport Axon Regeneration Establishment Of Protein Localization Regulation Of Oxidative Phosphorylation Regulation Of Smooth Muscle Cell Proliferation Lipid Metabolic Process Glucose Metabolic Process Negative Regulation Of Intracellular Protein Transport Negative Regulation Of Cytokine Production Negative Regulation Of Lipoprotein Lipid Oxidation Neuron Projection Regeneration Regeneration Small Molecule Metabolic Process Regulation Of Hormone Secretion Response To Xenobiotic Stimulus Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Secretion By Cell Positive Regulation Of Transport Negative Regulation Of Secretion By Cell Positive Regulation Of Glial Cell Proliferation Regulation Of Small Molecule Metabolic Process Negative Regulation Of Corticosterone Secretion Negative Regulation Of Lipid Transport Chemical Homeostasis Response To Alcohol Positive Regulation Of Monoatomic Ion Transmembrane Transport Endoplasmic Reticulum Membrane Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Albendazole Monooxygenase Activity Response To Desipramine Regulation Of Aerobic Respiration Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity
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