SMCO4 and KIR3DL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMCO4	KIR3DL1
Description		single-pass membrane protein with coiled-coil domains 4	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Amyloid-beta Binding Protein Binding HLA-B Specific Inhibitory MHC Class I Receptor Activity Molecular Adaptor Activity
	Biological Process		Immune Response-regulating Signaling Pathway Immune Response Natural Killer Cell Mediated Cytotoxicity
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Adult body size ( 32376654) Insulin levels in response to oral glucose tolerance test (30 minutes) ( 29093273) Liver enzyme levels (alanine transaminase) ( 33972514)	Lymphocyte count ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		62 interacting genes: AQP6 ARL13B BNIP3L CD79A CLEC10A CLTRN CPLX4 CREB3L1 CXCR2 EBP ELOVL4 ERGIC3 FAM174A FAM209A FAM210B FFAR2 GJA8 GKN1 GPA33 GPR152 GPR42 HHLA2 ICAM3 IL10RA KASH5 KCNK5 KIR3DL1 KRT40 KRTAP10-3 KRTAP10-7 LEPROTL1 LMNA LRRC25 M6PR MGST3 MS4A3 MUC1 PEX12 PLD3 PTGES RETREG3 SCN3B SLC10A6 SLC16A2 SLC18A1 SLC35H1 SLC41A3 SLC7A1 SLC7A14 SMIM3 SPINT1 STOM SUSD3 SYNE4 SYNPR TEX29 TFEC TMEM139 TMEM80 TMX2 VSIR WBP1	7 interacting genes: BMP10 CDK3 HLA-B RPS6KB1 SMCO4 TAFA2 THSD7B
Entrez ID		56935	3811
HPRD ID		17008	09226
Ensembl ID		ENSG00000166002	ENSG00000167633
Uniprot IDs		Q9NRQ5	P43629 Q5UCE2 Q6H2G3 Q8N6C9
PDB IDs			3VH8 3WUW 5B38 5B39 5T6Z 5T70 6V3J 7K80 7K81 9BL2 9BL3 9BL4 9BL5 9BL6 9BL9 9BLA
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding	Regulation Of Immune Response Immune Response-regulating Signaling Pathway
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