IDS

Description		iduronate 2-sulfatase
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GO Annotations	Cellular Component	Lysosome Lysosomal Lumen
	Molecular Function	Iduronate-2-sulfatase Activity Calcium Ion Binding Protein Binding Sulfuric Ester Hydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Glycosaminoglycan Catabolic Process Heparan Sulfate Proteoglycan Catabolic Process Dermatan Sulfate Proteoglycan Catabolic Process Carbohydrate Derivative Catabolic Process
Pathways		HS-GAG degradation CS/DS degradation MPS II - Hunter syndrome (HS-GAG degradation) MPS II - Hunter syndrome (CS/DS degradation)
Drugs
Diseases		Mucopolysaccharidosis type II (MPS2); Hunter syndrome
GWAS		Cognitive performance ( 20125193) Idiopathic downbeat nystagmus ( 32157568)
Novel Interacting Genes		2 novel interacting genes: IRAK1 PSMG1
Interacting Genes		4 interacting genes: FTCD HTR6 LCOR RUNX1
Entrez ID		3423
HPRD ID		02402
Ensembl ID		ENSG00000010404
Uniprot IDs		B4DGD7 P22304
PDB IDs		5FQL 6IOZ
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Binding Proteasome Core Complex Assembly Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity L-histidine Catabolic Process To Glutamate And Formate L-histidine Catabolic Process To Glutamate And Formamide
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