IDS and FTCD

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		IDS	FTCD
Description		iduronate 2-sulfatase	formimidoyltransferase cyclodeaminase
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Lumen	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Centriole Cytosol Cytoskeleton Plasma Membrane Smooth Endoplasmic Reticulum Membrane Extracellular Exosome
	Molecular Function	Iduronate-2-sulfatase Activity Calcium Ion Binding Protein Binding Sulfuric Ester Hydrolase Activity Hydrolase Activity Metal Ion Binding	Catalytic Activity Protein Binding Folic Acid Binding Microtubule Binding Transferase Activity Lyase Activity Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity
	Biological Process	Glycosaminoglycan Catabolic Process Heparan Sulfate Proteoglycan Catabolic Process Dermatan Sulfate Proteoglycan Catabolic Process Carbohydrate Derivative Catabolic Process	L-histidine Metabolic Process Folic Acid-containing Compound Metabolic Process Cytoskeleton Organization L-histidine Catabolic Process To Glutamate And Formamide L-histidine Catabolic Process To Glutamate And Formate
Pathways		HS-GAG degradation CS/DS degradation MPS II - Hunter syndrome (HS-GAG degradation) MPS II - Hunter syndrome (CS/DS degradation)	Histidine catabolism
Drugs			Tetrahydrofolic acid Glutamic acid (6R)-Folinic acid
Diseases		Mucopolysaccharidosis type II (MPS2); Hunter syndrome
GWAS		Cognitive performance ( 20125193) Idiopathic downbeat nystagmus ( 32157568)	Blood protein levels ( 30072576) Mastocytosis ( 32752121) Refractive error ( 32231278)
Interacting Genes		4 interacting genes: FTCD HTR6 LCOR RUNX1	23 interacting genes: BEX3 BIRC2 CCDC183 DGCR6 DNM1 DST EIF4A1 EIF4A2 GAD2 HGS HSPA1A HSPA1B HSPA2 IDS KASH5 MED4 NAA25 PALS1 RDX SNRNP70 SPTBN1 USP34 ZMYM5
Entrez ID		3423	10841
HPRD ID		02402	08430
Ensembl ID		ENSG00000010404	ENSG00000160282
Uniprot IDs		B4DGD7 P22304	O95954
PDB IDs		5FQL 6IOZ
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Binding Proteasome Core Complex Assembly Glutamate Formimidoyltransferase Activity Formimidoyltetrahydrofolate Cyclodeaminase Activity L-histidine Catabolic Process To Glutamate And Formate L-histidine Catabolic Process To Glutamate And Formamide	Negative Regulation Of Inclusion Body Assembly Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Heat Shock Protein Binding Regulation Of Inclusion Body Assembly Response To Heat Protein Refolding ATP-dependent Protein Folding Chaperone C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Negative Regulation Of Cellular Component Organization Cellular Response To Heat Positive Regulation Of Microtubule Nucleation Response To Temperature Stimulus Protein Folding Chaperone Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process RNA Binding ATP Hydrolysis Activity Eukaryotic Translation Initiation Factor 4F Complex Regulation Of Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Negative Regulation Of Post-translational Protein Modification Inclusion Body Regulation Of Microtubule Nucleation Regulation Of Post-translational Protein Modification Regulation Of Mitotic Spindle Assembly Protein-containing Complex Unfolded Protein Binding Blood Microparticle Histone Deacetylase Binding Protein Localization To Membrane Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Macromolecule Biosynthetic Process Extracellular Exosome Clathrin Coat Assembly Involved In Endocytosis Cytoplasmic Translational Initiation Negative Regulation Of RNA-dependent RNA Polymerase Activity Positive Regulation Of Male Mating Behavior Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Erythrocyte Differentiation Aggresome Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
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