HTR5A and WRN

Data Source: HiPPIP (Novel)

		HTR5A	WRN
Name		5-hydroxytryptamine receptor 5A	WRN RecQ like helicase
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Perikaryon Postsynaptic Specialization Membrane	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Nucleolus Cytoplasm Centrosome Nuclear Speck
	Molecular Function	Gi/o-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Neurotransmitter Receptor Activity Serotonin Receptor Activity	Nucleotide Binding Magnesium Ion Binding Four-way Junction DNA Binding Y-form DNA Binding Bubble DNA Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Catalytic Activity Helicase Activity Nuclease Activity Exonuclease Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Four-way Junction Helicase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Manganese Ion Binding MutLalpha Complex Binding Protein Homodimerization Activity 3'-5' DNA Helicase Activity Protein-containing Complex Binding Metal Ion Binding G-quadruplex DNA Binding Forked DNA-dependent Helicase Activity Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding 3'-flap-structured DNA Binding Catalytic Activity, Acting On DNA 8-hydroxy-2'-deoxyguanosine DNA Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Hippocampus Development Response To Estradiol	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Synthesis Involved In DNA Repair Nucleobase-containing Compound Metabolic Process DNA Metabolic Process DNA Replication DNA Repair Base-excision Repair Mismatch Repair Double-strand Break Repair DNA Recombination DNA Damage Response Response To Oxidative Stress Determination Of Adult Lifespan Cellular Response To Starvation Response To UV-C Replication Fork Processing Telomere Maintenance Via Semi-conservative Replication DNA Geometric Change Regulation Of Growth Rate Positive Regulation Of Hydrolase Activity Telomeric D-loop Disassembly Cellular Response To Gamma Radiation Cellular Senescence Replicative Senescence T-circle Formation Positive Regulation Of Strand Invasion Protein Localization To Nucleolus
Pathways		Serotonin receptors G alpha (i) signalling events	Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs		Ziprasidone Loxapine Aripiprazole Asenapine	None
Diseases		None	Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
GWAS		Bladder cancer (smoking interaction) ( 24662972 ) Energy expenditure (24h) ( 28476931 ) Personality dimensions ( 23903073 )	Chronotype ( 30696823 ) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 28084903 ) Daytime sleep phenotypes ( 27126917 ) Exercise treadmill test traits ( 17903301 ) Fasting glucose change (long-term) ( 31263163 ) Heel bone mineral density x serum urate levels interaction ( 34046847 ) Intelligence (MTAG) ( 29326435 ) Lifespan ( 25918517 ) Logical memory (delayed recall) in mild cognitive impairment ( 29274321 ) Logical memory (immediate recall) in mild cognitive impairment ( 29274321 ) Metabolite levels ( 23823483 ) Morning person ( 30696823 )
Novel Interactors		1 novel interactors: WRN	4 novel interactors: ADRB3 HTR5A LINC03042 UBXN8
Interacting Genes		2 interacting genes: BUD31 CFTR	34 interacting genes: ATM ATRX BARD1 BLM BRCA1 CDKN2A FEN1 H2AX MDC1 MDM2 MIB1 PARP1 PCNA POLB POLD2 POLK POLR1C PRKAR1B PRKDC RAD1 RAD51 RAD52 RAD54B RAD9A RPA1 RPA2 SUMO1 SUMO2 TERF2 TP53 VCP WRNIP1 XRCC5 XRCC6
Entrez ID		3361	7486
HPRD ID		03198	05212
Ensembl ID		ENSG00000157219	ENSG00000165392
Uniprot IDs		A4D2N2 P47898	Q14191
PDB IDs		7UM4 7UM5 7UM6 7UM7 7X5H	2AXL 2DGZ 2E1E 2E1F 2FBT 2FBV 2FBX 2FBY 2FC0 3AAF 6TYV 6YHR 7GQS 7GQT 7GQU 7XUT 8PFL 8PFO 8PFP 8YLE
GO Terms Enriched among Interactors		Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Strand Invasion 3'-flap-structured DNA Binding Isomerase Activity Positive Regulation Of Anion Channel Activity Forked DNA-dependent Helicase Activity Positive Regulation Of Monoatomic Anion Transport 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Positive Regulation Of Enamel Mineralization Telomeric D-loop Binding Catalytic Activity, Acting On DNA Y-form DNA Binding Transepithelial Water Transport Regulation Of Growth Rate Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity ATP Hydrolysis Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization DNA Geometric Change Four-way Junction Helicase Activity Bubble DNA Binding MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Amelogenesis Telomeric D-loop Disassembly G-quadruplex DNA Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Protein Localization To Nucleolus Telomeric Loop Disassembly T-circle Formation Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport 3'-5' DNA Helicase Activity Golgi-associated Vesicle Membrane Response To UV-C Cellular Response To Forskolin Replicative Senescence 3'-5' Exonuclease Activity Response To Forskolin Four-way Junction DNA Binding DNA Conformation Change Chloride Transmembrane Transporter Activity Sperm Capacitation	DNA Repair DNA Damage Response DNA Metabolic Process Cellular Response To Stress Response To Ionizing Radiation Double-strand Break Repair Nucleic Acid Metabolic Process Damaged DNA Binding Chromosome, Telomeric Region Response To Radiation DNA Recombination Recombinational Repair Cellular Response To Radiation Nucleobase-containing Compound Metabolic Process Response To Stress Telomere Maintenance Cellular Response To Ionizing Radiation Telomere Organization Regulation Of DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Signal Transduction In Response To DNA Damage Response To Gamma Radiation Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Chromosome Organization Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle Process Protein Localization To Chromosome Nucleoplasm Regulation Of Cell Cycle Process Regulation Of DNA Repair DNA Binding Regulation Of Cell Cycle Phase Transition DNA Biosynthetic Process Site Of Double-strand Break Enzyme Binding Negative Regulation Of Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Nuclear Body Regulation Of Cell Cycle DNA Replication Cellular Response To Gamma Radiation Protein Localization To Organelle PML Body Replication Fork Processing Protein-containing Complex Regulation Of DNA Recombination Negative Regulation Of Mitotic Cell Cycle