HTR5A and BUD31

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		HTR5A	BUD31
Description		5-hydroxytryptamine receptor 5A	BUD31 spliceosome associated protein
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Perikaryon Postsynaptic Specialization Membrane	Chromatin Nucleus Nucleoplasm Spliceosomal Complex Centrosome Microtubule Cytoskeleton U2-type Catalytic Step 2 Spliceosome
	Molecular Function	Gi/o-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Neurotransmitter Receptor Activity Serotonin Receptor Activity	Transcription Coactivator Activity Protein Binding Nuclear Receptor Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Hippocampus Development Response To Estradiol	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Positive Regulation Of DNA-templated Transcription
Pathways		Serotonin receptors G alpha (i) signalling events	mRNA Splicing - Major Pathway
Drugs		Ziprasidone Loxapine Aripiprazole Asenapine
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Energy expenditure (24h) ( 28476931) Personality dimensions ( 23903073)	Facial emotion recognition (sad faces) ( 28608620) Serum metabolite levels ( 23093944)
Interacting Genes		2 interacting genes: BUD31 CFTR	25 interacting genes: ADCY7 APP ATP13A1 BEND5 CCT3 CEBPA CTNNBL1 ERGIC3 HLA-A HOXA1 HTR5A KRTAP10-3 KRTAP10-7 MARCHF6 MEOX2 MMP24 NPC1 PANX1 PICK1 RELB RNF208 SCAF1 SF1 TMEM94 TSPAN7
Entrez ID		3361	8896
HPRD ID		03198	10351
Ensembl ID		ENSG00000157219	ENSG00000106245
Uniprot IDs		A4D2N2 P47898	P41223
PDB IDs		7UM4 7UM5 7UM6 7UM7 7X5H	4OED 4OH6 4OKB 5MQF 5XJC 5YZG 5Z56 5Z57 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7AAV 7ABF 7ABG 7ABI 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8Q7N 8QO9 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Strand Invasion 3'-flap-structured DNA Binding Isomerase Activity Positive Regulation Of Anion Channel Activity Forked DNA-dependent Helicase Activity Positive Regulation Of Monoatomic Anion Transport 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Positive Regulation Of Enamel Mineralization Telomeric D-loop Binding Catalytic Activity, Acting On DNA Y-form DNA Binding Transepithelial Water Transport Regulation Of Growth Rate Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity ATP Hydrolysis Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization DNA Geometric Change Four-way Junction Helicase Activity Bubble DNA Binding MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Amelogenesis Telomeric D-loop Disassembly G-quadruplex DNA Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Protein Localization To Nucleolus Telomeric Loop Disassembly T-circle Formation Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport 3'-5' DNA Helicase Activity Golgi-associated Vesicle Membrane Response To UV-C Cellular Response To Forskolin Replicative Senescence 3'-5' Exonuclease Activity Response To Forskolin Four-way Junction DNA Binding DNA Conformation Change Chloride Transmembrane Transporter Activity Sperm Capacitation
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