HTR5A

Description		5-hydroxytryptamine receptor 5A
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GO Annotations	Cellular Component	Plasma Membrane Membrane Dendrite Perikaryon Postsynaptic Specialization Membrane
	Molecular Function	Gi/o-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Neurotransmitter Receptor Activity Serotonin Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Hippocampus Development Response To Estradiol
Pathways		Serotonin receptors G alpha (i) signalling events
Drugs		Ziprasidone Loxapine Aripiprazole Asenapine
Diseases
GWAS		Bladder cancer (smoking interaction) ( 24662972) Energy expenditure (24h) ( 28476931) Personality dimensions ( 23903073)
Novel Interacting Genes		1 novel interacting genes: WRN
Interacting Genes		2 interacting genes: BUD31 CFTR
Entrez ID		3361
HPRD ID		03198
Ensembl ID		ENSG00000157219
Uniprot IDs		A4D2N2 P47898
PDB IDs		7UM4 7UM5 7UM6 7UM7 7X5H
Enriched GO Terms of Interacting Partners?		Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Strand Invasion 3'-flap-structured DNA Binding Isomerase Activity Positive Regulation Of Anion Channel Activity Forked DNA-dependent Helicase Activity Positive Regulation Of Monoatomic Anion Transport 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Positive Regulation Of Enamel Mineralization Telomeric D-loop Binding Catalytic Activity, Acting On DNA Y-form DNA Binding Transepithelial Water Transport Regulation Of Growth Rate Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity ATP Hydrolysis Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization DNA Geometric Change Four-way Junction Helicase Activity Bubble DNA Binding MutLalpha Complex Binding Telomere Maintenance Via Semi-conservative Replication Amelogenesis Telomeric D-loop Disassembly G-quadruplex DNA Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Protein Localization To Nucleolus Telomeric Loop Disassembly T-circle Formation Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport 3'-5' DNA Helicase Activity Golgi-associated Vesicle Membrane Response To UV-C Cellular Response To Forskolin Replicative Senescence 3'-5' Exonuclease Activity Response To Forskolin Four-way Junction DNA Binding DNA Conformation Change Chloride Transmembrane Transporter Activity Sperm Capacitation
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