HSPB1 and TJP2

Number of citations of the paper that reports this interaction (PubMedID 25277244)
81

Data Source:
BioGRID (two hybrid)

		HSPB1	TJP2
Description		heat shock protein family B (small) member 1	tight junction protein 2
Image
GO Annotations	Cellular Component	Proteasome Complex Cornified Envelope Extracellular Space Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Z Disc Contractile Muscle Fiber Extracellular Exosome Axon Cytoplasm	Nucleus Nucleoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Cell-cell Contact Zone Tight Junction Anchoring Junction
	Molecular Function	RNA Binding Protein Kinase C Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Protein Folding Chaperone Unfolded Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	GMP Kinase Activity Protein Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Cadherin Binding Cell Adhesion Molecule Binding Protein Tyrosine Kinase Binding
	Biological Process	Regulation Of Protein Phosphorylation Regulation Of Translational Initiation Protein Folding Response To Unfolded Protein Response To Heat Response To Virus Regulation Of Autophagy Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Protein Refolding Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Platelet Aggregation Negative Regulation Of Protein Kinase C Signaling Anterograde Axonal Protein Transport Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Apoptotic Signaling Pathway	Homotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Cell-cell Junction Organization GMP Metabolic Process GDP Metabolic Process Intestinal Absorption Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Cell-cell Adhesion Protein Localization To Cell-cell Junction Positive Regulation Of Blood-brain Barrier Permeability
Pathways		VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs		Apatorsen Artenimol Phenethyl Isothiocyanate
Diseases		Distal hereditary motor neuropathies (dHMN)
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Schizophrenia ( 30285260)	Macular thickness ( 30535121) Myopia ( 27182965) Night sleep phenotypes ( 27126917) Refractive error ( 23396134 32231278) Renal sinus fat ( 22044751) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)
Interacting Genes		248 interacting genes: ACAP2 ACBD6 ACTC1 ACTN1 ACTN2 ACTN4 ADCY9 ADD3 ADPRS AGAP10P AGAP3 AGAP4 AGAP5 AGAP7P AKT1 ALPI AMD1 ANAPC7 ANK1 ANKRD7 ANXA1 AP2B1 APPL1 ARHGAP28 ARHGEF7 ARIH1 ARRDC5 ATXN10 BICDL1 C11orf98 CAMK1 CBX1 CCDC32 CCDC70 CCHCR1 CCNC CCNDBP1 CCNO CDK5RAP3 CENPK CEP78 CETN3 CFAP251 CIMIP6 CLCN3 CPSF3 CRNKL1 CRYAA CRYAB CRYBB2 CRYGC CS CYCS DAXX DCPH1 DES DMAP1 DNAJC21 ECPAS EHD1 EIF1AX EIF2S1 EIF3M EIF4G1 EIF4G3 EIF5 ENPP2 EPB41L1 EPB41L2 EPB41L3 ERCC5 ERICH6 ESR1 FLNB FNDC3B FOXP1 FXR1 FXR2 GAPVD1 GARIN2 GDI2 GLMN GNPAT GOLGA8A GRIPAP1 GRK3 GSTO1 GTSF1 GUCA1A HAUS8 HDLBP HNRNPD HNRNPU HSP90AB1 HSPA4 HSPB8 IARS2 IGBP1 IGSF21 INPP5K INS ISG20L2 KANSL1 KCMF1 KCTD3 KLC1 KNSTRN KPNA3 KRT18 KRT72 LBP LIG1 LONRF1 LRIF1 LSM3 LUZP1 MAPK14 MAPKAPK2 MAPKAPK3 MAPKAPK5 MCM6 MDH2 MED31 MFAP1 MPHOSPH6 MRGBP MRPL28 MRPL40 MRPS23 MSL1 MTIF2 MYG1 MYL12A MYL12B MYL9 MYLK NAP1L1 NAPA NBAS NCKIPSD NEK10 NEXN NFKBIA NFU1 NSMCE4A NVL OBSL1 OPTN OSBPL9 PAF1 PALM3 PELO PGM2 PHYHIPL PLG PNISR PNPT1 POP7 POPDC1 PPA1 PPM1A PPP2R3C PRPF19 PRPF40A PSMA3 PSMA6 PSMB2 PSMC1 PSMD1 PTGES3 PTPN3 PTPRA RAB41 RAD23A RALA RASSF9 RBM25 RBM48 RBPJ RPAP3 RPSA RSPH3 RYBP S100A4 SAT1 SBF1 SEC13 SERTAD1 SF3A3 SF3B3 SLC26A4-AS1 SLC7A9 SLC9D1 SMARCA2 SMARCA4 SMARCD1 SNRNP200 SNRPF SPACA7 SPATA7 SPIN1 SPTBN1 SRP72 STUB1 SUMO2 SUPT5H SYCE1 TARBP2 TARS1 TBC1D1 TBC1D3B TGFB1I1 TGM1 THOC5 TJP2 TOMM70 TOX4 TP53 TPT1 TRIM24 TRIM54 TRIM63 TSNAXIP1 TTC3 TTC39C TXNL1 UCHL5 UFD1 UQCC2 UQCRB VIM WASHC3 WDR83 WEE2-AS1 WWP1 XPO1 XRCC5 YWHAB YWHAE YWHAH YWHAQ YWHAZ ZBTB17 ZBTB37 ZFAT ZNF131 ZNF197 ZNRF3	16 interacting genes: CDK6 CGN CLDN1 CLDN2 CLK1 CTNNA1 EPB41 HGS HSPB1 SAFB SCRIB SH3KBP1 TJP1 YWHAB YWHAG YWHAZ
Entrez ID		3315	9414
HPRD ID		09076	06369
Ensembl ID		ENSG00000106211	ENSG00000119139
Uniprot IDs		P04792 V9HW43	A0A3B3IU51 B7Z2R3 B7Z954 Q9UDY2
PDB IDs		2N3J 3Q9P 3Q9Q 4MJH 6DV5 6GJH	2OSG 3E17
Enriched GO Terms of Interacting Partners?		Cytosol RNA Binding Cytoplasm Nucleus Z Disc Nucleoplasm Translational Initiation Protein-RNA Complex Assembly Proteasome Complex Cytoskeletal Protein Binding Catalytic Step 2 Spliceosome Translation Initiation Factor Activity Positive Regulation Of Biosynthetic Process Protein-containing Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catabolic Process Structural Constituent Of Eye Lens Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Component Assembly Nuclear Matrix Positive Regulation Of Metabolic Process Intracellular Protein Localization Regulation Of Cellular Localization Protein-containing Complex Organization M Band Regulation Of Telomere Maintenance Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Heat Regulation Of Intracellular Transport Cellular Response To Topologically Incorrect Protein Focal Adhesion Positive Regulation Of RNA Metabolic Process Telomerase Holoenzyme Complex Assembly Phosphoserine Residue Binding Calcium-dependent Protein Serine/threonine Kinase Activity Protein Localization To Organelle Regulation Of Chromosome Organization Glutamatergic Synapse Regulation Of Cell Cycle Spliceosomal Complex MRNA Metabolic Process MRNA Processing U2-type Precatalytic Spliceosome Protein Folding Chaperone Complex Positive Regulation Of Translation Stress-induced Premature Senescence Myosin Heavy Chain Binding Organelle Organization Identical Protein Binding	Cell Junction Anchoring Junction Cadherin Binding Cell-cell Junction Focal Adhesion Protein Kinase C Inhibitor Activity Cell-cell Adhesion Cell-cell Junction Assembly Tight Junction Bicellular Tight Junction Protein Localization To Adherens Junction Protein Sequestering Activity Negative Regulation Of Protein Localization To Nucleus Phosphoserine Residue Binding Cell-cell Junction Organization Structural Molecule Activity Protein Targeting Protein Domain Specific Binding Regulation Of Multicellular Organismal Process Basolateral Plasma Membrane Regulation Of Intestinal Absorption Protein Localization To Cell Junction Intracellular Protein Localization Cell Adhesion Cell Junction Assembly Establishment Of Endothelial Intestinal Barrier Regulation Of Developmental Process Regulation Of Translational Initiation Protein Localization To Cell-cell Junction Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Regulation Of Bicellular Tight Junction Assembly Epithelial Cell Development Regulation Of Protein Localization To Nucleus Maintenance Of Blood-brain Barrier Establishment Of Endothelial Barrier Phosphoprotein Binding Identical Protein Binding Anatomical Structure Homeostasis Tissue Homeostasis Adherens Junction Establishment Of Protein Localization Endothelial Cell Development Cell Junction Organization Bicellular Tight Junction Assembly Cyclin D2-CDK6 Complex Negative Regulation Of Protein Kinase C Signaling Protein Kinase C Binding Negative Regulation Of Translational Initiation Xenobiotic Transport Across Blood-nerve Barrier Cellular Response To Glucose Starvation
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