HSPB1 and CPSF3

Number of citations of the paper that reports this interaction (PubMedID 25277244)
81

Data Source:
BioGRID (two hybrid)

		HSPB1	CPSF3
Description		heat shock protein family B (small) member 1	cleavage and polyadenylation specific factor 3
Image
GO Annotations	Cellular Component	Proteasome Complex Cornified Envelope Extracellular Space Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Z Disc Contractile Muscle Fiber Extracellular Exosome Axon Cytoplasm	Nucleus Nucleoplasm MRNA Cleavage And Polyadenylation Specificity Factor Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Kinase C Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Protein Folding Chaperone Unfolded Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Regulation Of Protein Phosphorylation Regulation Of Translational Initiation Protein Folding Response To Unfolded Protein Response To Heat Response To Virus Regulation Of Autophagy Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Protein Refolding Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Platelet Aggregation Negative Regulation Of Protein Kinase C Signaling Anterograde Axonal Protein Transport Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Apoptotic Signaling Pathway	MRNA Processing MRNA 3'-end Processing By Stem-loop Binding And Cleavage MRNA 3'-end Processing Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Transport of Mature mRNA Derived from an Intronless Transcript mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs		Apatorsen Artenimol Phenethyl Isothiocyanate
Diseases		Distal hereditary motor neuropathies (dHMN)
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Schizophrenia ( 30285260)
Interacting Genes		248 interacting genes: ACAP2 ACBD6 ACTC1 ACTN1 ACTN2 ACTN4 ADCY9 ADD3 ADPRS AGAP10P AGAP3 AGAP4 AGAP5 AGAP7P AKT1 ALPI AMD1 ANAPC7 ANK1 ANKRD7 ANXA1 AP2B1 APPL1 ARHGAP28 ARHGEF7 ARIH1 ARRDC5 ATXN10 BICDL1 C11orf98 CAMK1 CBX1 CCDC32 CCDC70 CCHCR1 CCNC CCNDBP1 CCNO CDK5RAP3 CENPK CEP78 CETN3 CFAP251 CIMIP6 CLCN3 CPSF3 CRNKL1 CRYAA CRYAB CRYBB2 CRYGC CS CYCS DAXX DCPH1 DES DMAP1 DNAJC21 ECPAS EHD1 EIF1AX EIF2S1 EIF3M EIF4G1 EIF4G3 EIF5 ENPP2 EPB41L1 EPB41L2 EPB41L3 ERCC5 ERICH6 ESR1 FLNB FNDC3B FOXP1 FXR1 FXR2 GAPVD1 GARIN2 GDI2 GLMN GNPAT GOLGA8A GRIPAP1 GRK3 GSTO1 GTSF1 GUCA1A HAUS8 HDLBP HNRNPD HNRNPU HSP90AB1 HSPA4 HSPB8 IARS2 IGBP1 IGSF21 INPP5K INS ISG20L2 KANSL1 KCMF1 KCTD3 KLC1 KNSTRN KPNA3 KRT18 KRT72 LBP LIG1 LONRF1 LRIF1 LSM3 LUZP1 MAPK14 MAPKAPK2 MAPKAPK3 MAPKAPK5 MCM6 MDH2 MED31 MFAP1 MPHOSPH6 MRGBP MRPL28 MRPL40 MRPS23 MSL1 MTIF2 MYG1 MYL12A MYL12B MYL9 MYLK NAP1L1 NAPA NBAS NCKIPSD NEK10 NEXN NFKBIA NFU1 NSMCE4A NVL OBSL1 OPTN OSBPL9 PAF1 PALM3 PELO PGM2 PHYHIPL PLG PNISR PNPT1 POP7 POPDC1 PPA1 PPM1A PPP2R3C PRPF19 PRPF40A PSMA3 PSMA6 PSMB2 PSMC1 PSMD1 PTGES3 PTPN3 PTPRA RAB41 RAD23A RALA RASSF9 RBM25 RBM48 RBPJ RPAP3 RPSA RSPH3 RYBP S100A4 SAT1 SBF1 SEC13 SERTAD1 SF3A3 SF3B3 SLC26A4-AS1 SLC7A9 SLC9D1 SMARCA2 SMARCA4 SMARCD1 SNRNP200 SNRPF SPACA7 SPATA7 SPIN1 SPTBN1 SRP72 STUB1 SUMO2 SUPT5H SYCE1 TARBP2 TARS1 TBC1D1 TBC1D3B TGFB1I1 TGM1 THOC5 TJP2 TOMM70 TOX4 TP53 TPT1 TRIM24 TRIM54 TRIM63 TSNAXIP1 TTC3 TTC39C TXNL1 UCHL5 UFD1 UQCC2 UQCRB VIM WASHC3 WDR83 WEE2-AS1 WWP1 XPO1 XRCC5 YWHAB YWHAE YWHAH YWHAQ YWHAZ ZBTB17 ZBTB37 ZFAT ZNF131 ZNF197 ZNRF3	10 interacting genes: CLP1 FAM107A HSPB1 MIR19A MIR19B1 MIR92A2 PAPOLA POLR2A RBBP6 YWHAG
Entrez ID		3315	51692
HPRD ID		09076	05825
Ensembl ID		ENSG00000106211	ENSG00000119203
Uniprot IDs		P04792 V9HW43	G5E9W3 Q9UKF6
PDB IDs		2N3J 3Q9P 3Q9Q 4MJH 6DV5 6GJH	2I7T 2I7V 6M8Q 6V4X 8T1Q 8T1R
Enriched GO Terms of Interacting Partners?		Cytosol RNA Binding Cytoplasm Nucleus Z Disc Nucleoplasm Translational Initiation Protein-RNA Complex Assembly Proteasome Complex Cytoskeletal Protein Binding Catalytic Step 2 Spliceosome Translation Initiation Factor Activity Positive Regulation Of Biosynthetic Process Protein-containing Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catabolic Process Structural Constituent Of Eye Lens Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Component Assembly Nuclear Matrix Positive Regulation Of Metabolic Process Intracellular Protein Localization Regulation Of Cellular Localization Protein-containing Complex Organization M Band Regulation Of Telomere Maintenance Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Heat Regulation Of Intracellular Transport Cellular Response To Topologically Incorrect Protein Focal Adhesion Positive Regulation Of RNA Metabolic Process Telomerase Holoenzyme Complex Assembly Phosphoserine Residue Binding Calcium-dependent Protein Serine/threonine Kinase Activity Protein Localization To Organelle Regulation Of Chromosome Organization Glutamatergic Synapse Regulation Of Cell Cycle Spliceosomal Complex MRNA Metabolic Process MRNA Processing U2-type Precatalytic Spliceosome Protein Folding Chaperone Complex Positive Regulation Of Translation Stress-induced Premature Senescence Myosin Heavy Chain Binding Organelle Organization Identical Protein Binding	Post-transcriptional Regulation Of Gene Expression Protein Kinase C Inhibitor Activity Post-transcriptional Gene Silencing Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Negative Regulation Of Matrix Metallopeptidase Secretion Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Extracellular Matrix Assembly RISC Complex Cellular Response To Bacterial Lipopeptide Response To Bacterial Lipoprotein Negative Regulation Of Fibroblast Migration MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Extracellular Matrix Assembly Negative Regulation Of Extracellular Matrix Organization Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Inflammatory Response To Antigenic Stimulus MRNA 3'-end Processing Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Immune Response Positive Regulation Of Heart Growth Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Striated Muscle Cell Apoptotic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Regulation Of Fibroblast Migration MRNA Metabolic Process Positive Regulation Of Striated Muscle Cell Differentiation Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Epithelial To Mesenchymal Transition Protein Kinase C Binding Positive Regulation Of Organ Growth Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Interleukin-6 Production Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of Metabolic Process MRNA Base-pairing Post-transcriptional Repressor Activity Negative Regulation Of Protein Kinase C Signaling Negative Regulation Of Reverse Cholesterol Transport Negative Regulation Of Apolipoprotein A-I-mediated Signaling Pathway Regulation Of Heart Growth Regulation Of Extracellular Matrix Organization Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Protein Secretion Positive Regulation Of Muscle Cell Differentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?