HSPB1 and ANAPC7

Number of citations of the paper that reports this interaction (PubMedID 25277244)
81

Data Source:
BioGRID (two hybrid)

		HSPB1	ANAPC7
Description		heat shock protein family B (small) member 1	anaphase promoting complex subunit 7
Image
GO Annotations	Cellular Component	Proteasome Complex Cornified Envelope Extracellular Space Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Z Disc Contractile Muscle Fiber Extracellular Exosome Axon Cytoplasm	Heterochromatin Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Cytoskeleton Intercellular Bridge Mitotic Spindle
	Molecular Function	RNA Binding Protein Kinase C Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Protein Folding Chaperone Unfolded Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Protein Phosphatase Binding Enzyme-substrate Adaptor Activity
	Biological Process	Regulation Of Protein Phosphorylation Regulation Of Translational Initiation Protein Folding Response To Unfolded Protein Response To Heat Response To Virus Regulation Of Autophagy Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Protein Refolding Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Platelet Aggregation Negative Regulation Of Protein Kinase C Signaling Anterograde Axonal Protein Transport Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Apoptotic Signaling Pathway	Regulation Of Mitotic Cell Cycle Brain Development Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination
Pathways		VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Apatorsen Artenimol Phenethyl Isothiocyanate
Diseases		Distal hereditary motor neuropathies (dHMN)
GWAS		Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Schizophrenia ( 30285260)	Bipolar disorder ( 31043756) QT interval ( 30679814) Schizophrenia ( 28991256) Total intracranial volume ( 31530798)
Interacting Genes		248 interacting genes: ACAP2 ACBD6 ACTC1 ACTN1 ACTN2 ACTN4 ADCY9 ADD3 ADPRS AGAP10P AGAP3 AGAP4 AGAP5 AGAP7P AKT1 ALPI AMD1 ANAPC7 ANK1 ANKRD7 ANXA1 AP2B1 APPL1 ARHGAP28 ARHGEF7 ARIH1 ARRDC5 ATXN10 BICDL1 C11orf98 CAMK1 CBX1 CCDC32 CCDC70 CCHCR1 CCNC CCNDBP1 CCNO CDK5RAP3 CENPK CEP78 CETN3 CFAP251 CIMIP6 CLCN3 CPSF3 CRNKL1 CRYAA CRYAB CRYBB2 CRYGC CS CYCS DAXX DCPH1 DES DMAP1 DNAJC21 ECPAS EHD1 EIF1AX EIF2S1 EIF3M EIF4G1 EIF4G3 EIF5 ENPP2 EPB41L1 EPB41L2 EPB41L3 ERCC5 ERICH6 ESR1 FLNB FNDC3B FOXP1 FXR1 FXR2 GAPVD1 GARIN2 GDI2 GLMN GNPAT GOLGA8A GRIPAP1 GRK3 GSTO1 GTSF1 GUCA1A HAUS8 HDLBP HNRNPD HNRNPU HSP90AB1 HSPA4 HSPB8 IARS2 IGBP1 IGSF21 INPP5K INS ISG20L2 KANSL1 KCMF1 KCTD3 KLC1 KNSTRN KPNA3 KRT18 KRT72 LBP LIG1 LONRF1 LRIF1 LSM3 LUZP1 MAPK14 MAPKAPK2 MAPKAPK3 MAPKAPK5 MCM6 MDH2 MED31 MFAP1 MPHOSPH6 MRGBP MRPL28 MRPL40 MRPS23 MSL1 MTIF2 MYG1 MYL12A MYL12B MYL9 MYLK NAP1L1 NAPA NBAS NCKIPSD NEK10 NEXN NFKBIA NFU1 NSMCE4A NVL OBSL1 OPTN OSBPL9 PAF1 PALM3 PELO PGM2 PHYHIPL PLG PNISR PNPT1 POP7 POPDC1 PPA1 PPM1A PPP2R3C PRPF19 PRPF40A PSMA3 PSMA6 PSMB2 PSMC1 PSMD1 PTGES3 PTPN3 PTPRA RAB41 RAD23A RALA RASSF9 RBM25 RBM48 RBPJ RPAP3 RPSA RSPH3 RYBP S100A4 SAT1 SBF1 SEC13 SERTAD1 SF3A3 SF3B3 SLC26A4-AS1 SLC7A9 SLC9D1 SMARCA2 SMARCA4 SMARCD1 SNRNP200 SNRPF SPACA7 SPATA7 SPIN1 SPTBN1 SRP72 STUB1 SUMO2 SUPT5H SYCE1 TARBP2 TARS1 TBC1D1 TBC1D3B TGFB1I1 TGM1 THOC5 TJP2 TOMM70 TOX4 TP53 TPT1 TRIM24 TRIM54 TRIM63 TSNAXIP1 TTC3 TTC39C TXNL1 UCHL5 UFD1 UQCC2 UQCRB VIM WASHC3 WDR83 WEE2-AS1 WWP1 XPO1 XRCC5 YWHAB YWHAE YWHAH YWHAQ YWHAZ ZBTB17 ZBTB37 ZFAT ZNF131 ZNF197 ZNRF3	18 interacting genes: ANAPC10 ANAPC2 BUB1B CDC16 CDC20 CDC27 CDH1 CDT1 CEBPA CREBBP FBXO5 FZR1 HSPB1 OGT PTEN PTGER4 UBC UBE2S
Entrez ID		3315	51434
HPRD ID		09076	16233
Ensembl ID		ENSG00000106211	ENSG00000196510
Uniprot IDs		P04792 V9HW43	Q4KMX6 Q9UJX3
PDB IDs		2N3J 3Q9P 3Q9Q 4MJH 6DV5 6GJH	3FFL 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Cytosol RNA Binding Cytoplasm Nucleus Z Disc Nucleoplasm Translational Initiation Protein-RNA Complex Assembly Proteasome Complex Cytoskeletal Protein Binding Catalytic Step 2 Spliceosome Translation Initiation Factor Activity Positive Regulation Of Biosynthetic Process Protein-containing Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catabolic Process Structural Constituent Of Eye Lens Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Component Assembly Nuclear Matrix Positive Regulation Of Metabolic Process Intracellular Protein Localization Regulation Of Cellular Localization Protein-containing Complex Organization M Band Regulation Of Telomere Maintenance Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Heat Regulation Of Intracellular Transport Cellular Response To Topologically Incorrect Protein Focal Adhesion Positive Regulation Of RNA Metabolic Process Telomerase Holoenzyme Complex Assembly Phosphoserine Residue Binding Calcium-dependent Protein Serine/threonine Kinase Activity Protein Localization To Organelle Regulation Of Chromosome Organization Glutamatergic Synapse Regulation Of Cell Cycle Spliceosomal Complex MRNA Metabolic Process MRNA Processing U2-type Precatalytic Spliceosome Protein Folding Chaperone Complex Positive Regulation Of Translation Stress-induced Premature Senescence Myosin Heavy Chain Binding Organelle Organization Identical Protein Binding	Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Binding Regulation Of Meiotic Cell Cycle Protein K11-linked Ubiquitination Cell Division Metaphase/anaphase Transition Of Cell Cycle Regulation Of Reproductive Process Regulation Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Cell Cycle Protein Branched Polyubiquitination Post-translational Protein Modification Regulation Of Chromosome Segregation Protein Ubiquitination Protein Modification Process Regulation Of Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Modification-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Spindle Regulation Of Chromosome Organization Ubiquitin Ligase Activator Activity Regulation Of Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Process Nucleoplasm Regulation Of Nuclear Division Protein Polyubiquitination Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction Regulation Of Mitotic Sister Chromatid Separation Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Separation Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Component Organization Proteolysis Regulation Of Organelle Organization Regulation Of Protein Ubiquitination Negative Regulation Of Cellular Senescence
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