UBR3 and UBE2B

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		UBR3	UBE2B
Gene Name		ubiquitin protein ligase E3 component n-recognin 3 (putative)	ubiquitin-conjugating enzyme E2B
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Chromatin Nuclear Chromatin XY Body Nucleus Replication Fork Cytoplasm Plasma Membrane HULC Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	In Utero Embryonic Development Suckling Behavior Ubiquitin-dependent Protein Catabolic Process Sensory Perception Of Smell Embryo Development Protein Ubiquitination Olfactory Behavior	Protein Polyubiquitination Response To Hypoxia In Utero Embryonic Development DNA Repair Postreplication Repair Maintenance Of Chromatin Silencing Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Spermatogenesis Sperm Axoneme Assembly Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Cellular Response To Insulin Stimulus Negative Regulation Of Histone Phosphorylation Histone H2A Ubiquitination Response To Drug Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of CAMP-mediated Signaling Protein Stabilization Chiasma Assembly Protein Autoubiquitination Canonical Wnt Signaling Pathway Histone Lysine Demethylation Synaptonemal Complex Organization Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: DZIP3 UBC UBE2A UBE2B	19 interactors: BIRC2 CDKN1B CNOT4 CRMP1 CTNNB1 HIST2H2AC MED31 PCNA RAD18 RNF20 RNF40 TRIM45 UBA1 UBC UBR1 UBR2 UBR3 UBR5 UNC119
Entrez ID		130507	7320
HPRD ID		15887	01533
Ensembl ID		ENSG00000144357	ENSG00000119048
Uniprot IDs		Q6ZT12	P63146
PDB IDs			1JAS 1NXA 2Y4W 2YB6 2YBF
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Histone H2A Ubiquitination Postreplication Repair Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Proteasomal Protein Catabolic Process Histone Ubiquitination Protein K48-linked Ubiquitination Protein Autoubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process DNA Repair Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Response To UV Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I DNA Metabolic Process Cellular Protein Modification Process Response To Abiotic Stimulus Negative Regulation Of Histone Phosphorylation Positive Regulation Of Reciprocal Meiotic Recombination Maintenance Of Chromatin Silencing Positive Regulation Of Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Positive Regulation Of Cell Cycle Antigen Processing And Presentation Response To Hypoxia Positive Regulation Of Meiosis I Cellular Response To Stress Proteolysis Cellular Protein Metabolic Process Response To Light Stimulus Negative Regulation Of CAMP-mediated Signaling Chiasma Assembly Regulation Of Meiosis I Histone Modification Catabolic Process Sperm Axoneme Assembly Viral Protein Processing Response To Radiation Regulation Of Cell Cycle Process In Utero Embryonic Development Protein Metabolic Process Positive Regulation Of Meiotic Nuclear Division Chromatin Modification	Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Catabolic Process Cellular Response To Leucine Proteolysis Histone Ubiquitination Cellular Protein Modification Process Regulation Of Protein K63-linked Ubiquitination Protein Polyubiquitination Response To Cadmium Ion Response To Leucine Histone H2B Ubiquitination Cellular Response To DNA Damage Stimulus Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Response To Amino Acid Cell Cycle Process Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Protein Metabolic Process Histone Monoubiquitination Regulation Of Histone Modification Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Wnt Signaling Pathway G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Negative Regulation Of TOR Signaling Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Organonitrogen Compound Positive Regulation Of Histone Methylation Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Regulation Of Cellular Protein Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Chromosome Organization Negative Regulation Of Protein Metabolic Process Protein Monoubiquitination Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Canonical Wnt Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cellular Metabolic Process
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