UBR3

Description		ubiquitin protein ligase E3 component n-recognin 3
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	In Utero Embryonic Development Suckling Behavior Ubiquitin-dependent Protein Catabolic Process Sensory Perception Of Smell Embryo Development Ending In Birth Or Egg Hatching Protein Ubiquitination Olfactory Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The N-end Rule Pathway Negative Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel
Pathways
Drugs
Diseases
GWAS		Longitudinal change in brain amyloid plaque burden ( 26268530) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Urate levels in obese individuals ( 25811787)
Novel Interacting Genes		1 novel interacting genes: BBS5
Interacting Genes		7 interacting genes: APEX1 DZIP3 MAGEC2 UBE2A UBE2B UBE2D2 UBE2H
Entrez ID		130507
HPRD ID		15887
Ensembl ID		ENSG00000144357
Uniprot IDs		Q6ZT12
PDB IDs
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Macromolecule Catabolic Process HULC Complex Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-like Protein Transferase Activity Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Postreplication Repair Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Binding Protein Modification Process Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Telomere Maintenance Via Base-excision Repair Transferase Activity Protein Autoubiquitination Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process DNA-(abasic Site) Binding Double-stranded DNA Exodeoxyribonuclease Activity Deoxyribonuclease (pyrimidine Dimer) Activity Macromolecule Metabolic Process Positive Regulation Of Reciprocal Meiotic Recombination Proteasomal Protein Catabolic Process Proteolysis DNA Repair Uracil DNA N-glycosylase Activity Phosphodiesterase I Activity ATP Binding Response To UV Double-stranded DNA 3'-5' DNA Exonuclease Activity Chiasma Assembly RNA-DNA Hybrid Ribonuclease Activity BBSome DNA Metabolic Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Double-stranded Telomeric DNA Binding Telomere Localization DNA Damage Response 3'-5'-DNA Exonuclease Activity Nucleotide Binding
Tagcloud ?