HRG and PLG

Number of citations of the paper that reports this interaction (PMID 8478593)
2

Data Source:
HPRD (in vivo)

		HRG	PLG
Gene Name		histidine-rich glycoprotein	plasminogen
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Platelet Alpha Granule Lumen Endolysosome Phagolysosome Membrane Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Platelet Alpha Granule Lumen Extrinsic Component Of External Side Of Plasma Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding Immunoglobulin Binding Heme Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding	Serine-type Endopeptidase Activity Receptor Binding Protein Binding Serine-type Peptidase Activity Protein Domain Specific Binding Apolipoprotein Binding
	Biological Process	Angiogenesis Platelet Degranulation Positive Regulation Of Immune Response To Tumor Cell Chemotaxis Negative Regulation Of Cell Adhesion Blood Coagulation Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Regulation Of Platelet Activation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Endopeptidase Activity Response To Organic Cyclic Compound Negative Regulation Of Angiogenesis Platelet Activation Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Fibrinolysis Positive Regulation Of Apoptotic Process Regulation Of Protein Complex Assembly Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Fungus Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Fibrinolysis Heme Export Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Endothelial Cell Chemotaxis	Platelet Degranulation Blood Coagulation Negative Regulation Of Cell Proliferation Negative Regulation Of Cell-substrate Adhesion Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Tissue Regeneration Fibrinolysis Cellular Protein Metabolic Process Myoblast Differentiation Muscle Cell Cellular Homeostasis Tissue Remodeling Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Fibrinolysis Positive Regulation Of Fibrinolysis Transmembrane Transport Trophoblast Giant Cell Differentiation Labyrinthine Layer Blood Vessel Development Mononuclear Cell Migration Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Dissolution of Fibrin Clot Platelet activation, signaling and aggregation	Signaling by PDGF Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activation of Matrix Metalloproteinases Dissolution of Fibrin Clot Platelet degranulation Degradation of the extracellular matrix Response to elevated platelet cytosolic Ca2+ Platelet activation, signaling and aggregation Orphan transporters
Drugs			Alteplase Urokinase Reteplase Anistreplase Tenecteplase Streptokinase Tranexamic Acid Aminocaproic Acid Bicine Aprotinin
Diseases
GWAS		Activated partial thromboplastin time ( 22703881 20303064)	Aging ( 22773346) Lp (a) levels ( 21900290)
Protein-Protein Interactions		13 interactors: C1QA C1QB CHRD FCGR1A FGA FN1 PLG PLSCR1 RABAC1 RCHY1 SPRY1 THBS1 TNFRSF1A	61 interactors: ACTB AMOT ANXA2 APOH ATP5B C7 CDCP1 CHGA CLEC3B CP CPB2 CXCL2 CYFIP2 ENO1 EP300 F10 F2R F2RL1 F3 FN1 HMGB1 HRG HSPA1A HSPB1 HSPD1 IGF2 IGFBP3 KLK3 KNG1 LAMA1 LAMA3 LAMA5 MAPK14 MEP1A MMP3 MMP7 MMP9 NGF PAPPA PCOLCE PLAT PLAU PRDX4 PRNP RAP2A RBBP6 RUVBL1 S100A10 SERPINB13 SERPINB6 SERPINC1 SERPINE1 SERPINF2 SERPING1 SERPINI1 SMAD3 SMAD4 SPARC TFPI2 THBS1 YTHDC1
Entrez ID		3273	5340
HPRD ID		00812	01417
Ensembl ID		ENSG00000113905	ENSG00000122194
Uniprot IDs		P04196	P00747 Q5TEH5
PDB IDs			1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2KNF 2L0S 2PK4 3UIR 4A5T 4DCB 4DUR 4DUU 5HPG
Enriched GO Terms of Interacting Partners?		Platelet Activation Platelet Degranulation Defense Response Response To Wounding Blood Coagulation Hemostasis Immune System Process Response To Stress Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Fibrinolysis Cell Activation Regulation Of Blood Coagulation Exocytosis Phagocytosis, Engulfment Regulation Of Fibrinolysis Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Wound Healing Membrane Invagination Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inflammatory Response Positive Regulation Of Immune System Process Response To Stimulus Protein Activation Cascade Secretion By Cell Regulation Of Cell-substrate Adhesion Positive Regulation Of Blood Coagulation Regulation Of Endothelial Cell Apoptotic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Acute-phase Response Positive Regulation Of Coagulation Regulation Of Cell Adhesion Secretion Positive Regulation Of Immune Response Peptide Cross-linking Immune Response Positive Regulation Of Wound Healing Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Immune System Process Response To Cytokine Negative Regulation Of Cell-substrate Adhesion Developmental Growth Regulation Of Protein Metabolic Process Negative Regulation Of Blood Coagulation Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Coagulation Vesicle-mediated Transport Negative Regulation Of Wound Healing Innate Immune Response	Regulation Of Blood Coagulation Regulation Of Wound Healing Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Regulation Of Protein Metabolic Process Negative Regulation Of Wound Healing Regulation Of Peptidase Activity Fibrinolysis Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Regulation Of Cell Migration Regulation Of Endopeptidase Activity Regulation Of Cell Motility Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Regulation Of Locomotion Regulation Of Cellular Component Movement Response To Stress Regulation Of Fibrinolysis Platelet Activation Regulation Of Protein Processing Positive Regulation Of Blood Coagulation Negative Regulation Of Fibrinolysis Cell Activation Positive Regulation Of Coagulation Platelet Degranulation Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Wound Healing Regulation Of Cell Adhesion Regulation Of Cell Proliferation Response To External Stimulus Negative Regulation Of Protein Processing Negative Regulation Of Cellular Protein Metabolic Process Response To Stimulus Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Defense Response Negative Regulation Of Endopeptidase Activity Positive Regulation Of Cellular Component Movement Negative Regulation Of Proteolysis Positive Regulation Of Locomotion Negative Regulation Of Peptidase Activity Zymogen Activation Negative Regulation Of Hydrolase Activity
Tagcloud ?		absorbed attack c5b c9 complement connected determinant erythrocytes guinea histidine lysis m1 m57 mga name overlapping possesses pyogenes regulon sensitized sepharose serotype serotypes sheep sic streptococcal streptococcus translates virulence	1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed
Tagcloud (Difference) ?		absorbed attack c5b c9 complement connected determinant erythrocytes guinea histidine lysis m1 m57 mga name overlapping possesses pyogenes regulon sensitized sepharose serotype serotypes sheep sic streptococcal streptococcus translates virulence	1f a2hs allel alleles asia borderline city comparatively corresponds deviating dissimilarity distance east ethnic f13b gc geographic jekaterinburg krakow moscow olomouc polymorphic poznan prague presumably regard szeged tf typed
Tagcloud (Intersection) ?