HRG and CHRD

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		HRG	CHRD
Gene Name		histidine-rich glycoprotein	chordin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Platelet Alpha Granule Lumen Endolysosome Phagolysosome Membrane Extracellular Vesicular Exosome Blood Microparticle	Extracellular Space
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding Immunoglobulin Binding Heme Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding	Protein Binding Heparin Binding Cytokine Binding Syndecan Binding
	Biological Process	Angiogenesis Platelet Degranulation Positive Regulation Of Immune Response To Tumor Cell Chemotaxis Negative Regulation Of Cell Adhesion Blood Coagulation Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Regulation Of Platelet Activation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Endopeptidase Activity Response To Organic Cyclic Compound Negative Regulation Of Angiogenesis Platelet Activation Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Fibrinolysis Positive Regulation Of Apoptotic Process Regulation Of Protein Complex Assembly Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Fungus Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Fibrinolysis Heme Export Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Endothelial Cell Chemotaxis	Skeletal System Development Osteoblast Differentiation Gastrulation With Mouth Forming Second Mesoderm Formation Positive Regulation Of Mesenchymal Cell Proliferation BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning Negative Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Forebrain Development Floor Plate Development Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Cell Adhesion
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Dissolution of Fibrin Clot Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881 20303064)	Platelet counts ( 20139978)
Protein-Protein Interactions		13 interactors: C1QA C1QB CHRD FCGR1A FGA FN1 PLG PLSCR1 RABAC1 RCHY1 SPRY1 THBS1 TNFRSF1A	26 interactors: ATN1 BMP1 BMP2 CATSPER1 CD36 F2R HOXA1 HRG KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 MEOX2 NOTCH2NL NR0B2 OTX1 PLSCR1 SMAD3 SPRY2 TLL1 TWSG1
Entrez ID		3273	8646
HPRD ID		00812	04592
Ensembl ID		ENSG00000113905	ENSG00000090539
Uniprot IDs		P04196	E7ESX1 Q9H2X0
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Platelet Degranulation Defense Response Response To Wounding Blood Coagulation Hemostasis Immune System Process Response To Stress Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Fibrinolysis Cell Activation Regulation Of Blood Coagulation Exocytosis Phagocytosis, Engulfment Regulation Of Fibrinolysis Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Wound Healing Membrane Invagination Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inflammatory Response Positive Regulation Of Immune System Process Response To Stimulus Protein Activation Cascade Secretion By Cell Regulation Of Cell-substrate Adhesion Positive Regulation Of Blood Coagulation Regulation Of Endothelial Cell Apoptotic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Acute-phase Response Positive Regulation Of Coagulation Regulation Of Cell Adhesion Secretion Positive Regulation Of Immune Response Peptide Cross-linking Immune Response Positive Regulation Of Wound Healing Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Immune System Process Response To Cytokine Negative Regulation Of Cell-substrate Adhesion Developmental Growth Regulation Of Protein Metabolic Process Negative Regulation Of Blood Coagulation Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Coagulation Vesicle-mediated Transport Negative Regulation Of Wound Healing Innate Immune Response	Developmental Process Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Gene Expression Anterior/posterior Pattern Specification Positive Regulation Of Blood Coagulation Regulation Of Wound Healing Anatomical Structure Morphogenesis Positive Regulation Of Coagulation Positive Regulation Of Cartilage Development Sensory Organ Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Wound Healing Organ Morphogenesis System Development Regulation Of Transcription, DNA-templated Positive Regulation Of Cell-matrix Adhesion Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Inner Ear Development Embryo Development Platelet Activation Pattern Specification Process Embryonic Organ Development Ear Development Positive Regulation Of Transcription, DNA-templated Response To Organic Substance Regulation Of Cartilage Development Positive Regulation Of Cellular Metabolic Process Skeletal System Development Regulation Of Blood Coagulation Ossification Positive Regulation Of Metabolic Process Inner Ear Morphogenesis Wound Healing Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cell Motility Embryonic Organ Morphogenesis Regulation Of Cell-matrix Adhesion Embryonic Morphogenesis Regulation Of Protein Phosphorylation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Cellular Biosynthetic Process Regulation Of Osteoblast Proliferation Negative Regulation Of Cell Proliferation
Tagcloud ?		absorbed attack c5b c9 complement connected determinant erythrocytes guinea histidine lysis m1 m57 mga name overlapping possesses pyogenes regulon sensitized sepharose serotype serotypes sheep sic streptococcal streptococcus translates virulence	affymetrix axin2 bglap2 bmp bridge chrdl2 cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1
Tagcloud (Difference) ?		absorbed attack c5b c9 complement connected determinant erythrocytes guinea histidine lysis m1 m57 mga name overlapping possesses pyogenes regulon sensitized sepharose serotype serotypes sheep sic streptococcal streptococcus translates virulence	affymetrix axin2 bglap2 bmp bridge chrdl2 cooperatively cpz csnk2a1 deformities fgfr1 fibrogenic fzd1 fzd2 groupings hgn id1 lef1 microdissection mmp9 osteogenic plate remodelling repaired sfrp1 sfrp4 spp1 tcf7 wisp1
Tagcloud (Intersection) ?