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HRG and FCGR1A
Number of citations of the paper that reports this interaction (PubMedID
10421785
)
0
Data Source:
HPRD
(in vivo)
HRG
FCGR1A
Description
histidine rich glycoprotein
Fc gamma receptor Ia
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Plasma Membrane
Cell Surface
Extracellular Matrix
Platelet Alpha Granule Lumen
Extracellular Exosome
Blood Microparticle
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Clathrin-coated Endocytic Vesicle Membrane
Early Endosome Membrane
Molecular Function
Serine-type Endopeptidase Inhibitor Activity
Cysteine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Heparin Binding
Zinc Ion Binding
Immunoglobulin Binding
Heme Binding
Heparan Sulfate Proteoglycan Binding
Metal Ion Binding
Protein Binding
IgG Receptor Activity
High-affinity IgG Receptor Activity
IgG Binding
Biological Process
Angiogenesis
Positive Regulation Of Immune Response To Tumor Cell
Chemotaxis
Negative Regulation Of Cell Adhesion
Blood Coagulation
Hemostasis
Negative Regulation Of Cell Population Proliferation
Regulation Of Gene Expression
Regulation Of Platelet Activation
Negative Regulation Of Lamellipodium Assembly
Negative Regulation Of Angiogenesis
Platelet Activation
Regulation Of Blood Coagulation
Negative Regulation Of Cell Growth
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of Cell Adhesion Mediated By Integrin
Fibrinolysis
Positive Regulation Of Apoptotic Process
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Fungus
Cytolysis By Host Of Symbiont Cells
Positive Regulation Of Focal Adhesion Assembly
Negative Regulation Of Fibrinolysis
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of Blood Vessel Remodeling
Negative Regulation Of Endothelial Cell Chemotaxis
Antibody-dependent Cellular Cytotoxicity
Positive Regulation Of Type IIa Hypersensitivity
Positive Regulation Of Type III Hypersensitivity
Immune System Process
Receptor-mediated Endocytosis
Phagocytosis, Recognition
Phagocytosis, Engulfment
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Response To Bacterium
Antigen Processing And Presentation Of Exogenous Antigen
Positive Regulation Of Tumor Necrosis Factor Production
Fc-gamma Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Defense Response To Bacterium
Innate Immune Response
Positive Regulation Of Phagocytosis
Regulation Of Immune Response
Pathways
Platelet degranulation
Dissolution of Fibrin Clot
Cross-presentation of soluble exogenous antigens (endosomes)
Cross-presentation of soluble exogenous antigens (endosomes)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
FCGR activation
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Interferon gamma signaling
FCGR3A-mediated IL10 synthesis
Drugs
Zinc chloride
Zinc sulfate, unspecified form
Cetuximab
Etanercept
Human immunoglobulin G
Gemtuzumab ozogamicin
Alemtuzumab
Natalizumab
Palivizumab
Daclizumab
Bevacizumab
Porfimer sodium
Catumaxomab
Sarilumab
Trastuzumab deruxtecan
Diseases
Inherited thrombophilia
GWAS
Activated partial thromboplastin time (
20303064
22703881
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Neurological blood protein biomarker levels (
31320639
)
Refractive error (
32231278
)
Interacting Genes
15 interacting genes:
C1QA
C1QB
CHRD
CYSRT1
FCGR1A
FGA
FN1
PLG
PLSCR1
RABAC1
RCHY1
RGS20
SPRY1
THBS1
TNFRSF1A
31 interacting genes:
ADIPOQ
APCS
ASGR1
BIK
BMP10
CD163
CLDN19
CLEC7A
CLIC6
CRKL
CRP
FAM3C
FCAR
FCGR3A
HCK
HRG
ITM2A
JAGN1
LAT
LHFPL5
LILRB2
MALL
NINJ1
NRSN1
RPRM
SYK
TNMD
TSPO2
UPK2
VSTM1
VTI1B
Entrez ID
3273
2209
HPRD ID
00812
00904
Ensembl ID
ENSG00000113905
ENSG00000150337
Uniprot IDs
P04196
P12314
PDB IDs
3RJD
4W4O
4X4M
4ZNE
8DIN
8DIR
8DJ7
Enriched GO Terms of Interacting Partners
?
Blood Coagulation, Fibrin Clot Formation
Fibrinogen Complex
IgG Binding
Platelet Alpha Granule Lumen
Protein Activation Cascade
Extracellular Matrix
Complement Component C1q Complex
Blood Microparticle
Biological Process Involved In Interaction With Symbiont
Defense Response
IgM Binding
Complement Component C1 Complex
Cell Surface
Phosphatidylserine Binding
Acute Inflammatory Response
Synapse Pruning
Regulation Of Hemostasis
Regulation Of Blood Coagulation
Regulation Of Cell-substrate Adhesion
Negative Regulation Of Fibrinolysis
Proteoglycan Binding
Inflammatory Response
Regulation Of Fibrinolysis
Protease Binding
Symbiont Cell Surface
Platelet Alpha Granule
Fibrinolysis
Extracellular Matrix Structural Constituent
Protein Maturation
Extracellular Region
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
External Side Of Plasma Membrane
Negative Regulation Of Protein Maturation
Response To Other Organism
Regulation Of Wound Healing
Positive Regulation Of Blood Coagulation
Negative Regulation Of Multicellular Organismal Process
Phagocytosis, Engulfment
Positive Regulation Of Coagulation
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Response To Stress
Complement Activation, Classical Pathway
Regulation Of Cell Adhesion
Regulation Of Response To Wounding
Response To External Biotic Stimulus
Acute-phase Response
Membrane Invagination
High-affinity IgG Receptor Activity
Regulation Of Cell Communication
Immune System Process
Immune Response-regulating Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Defense Response
Inflammatory Response
Immune Effector Process
Regulation Of Immune Response
Leukocyte Degranulation
Regulation Of Immune System Process
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Fc Receptor Signaling Pathway
Immune Response
Acute Inflammatory Response
Positive Regulation Of Superoxide Anion Generation
Regulation Of Superoxide Anion Generation
Positive Regulation Of Immune System Process
Response To External Biotic Stimulus
Regulation Of Cell Population Proliferation
Regulation Of Interleukin-8 Production
Regulation Of Superoxide Metabolic Process
Cellular Response To Molecule Of Fungal Origin
Membrane
Extracellular Region
Fc-gamma Receptor Signaling Pathway
Exocytosis
Response To Molecule Of Fungal Origin
Regulation Of Phagocytosis
Regulated Exocytosis
Plasma Membrane
Acute-phase Response
Leukocyte Migration
Immune Response-activating Cell Surface Receptor Signaling Pathway
Complement Component C1q Complex Binding
Phosphotyrosine Residue Binding
Regulation Of Cell Adhesion Mediated By Integrin
Neutrophil Differentiation
Response To Other Organism
Positive Regulation Of Myeloid Cell Apoptotic Process
Defense Response To Fungus
Cell Activation
Virion Binding
Positive Regulation Of Immune Response
Response To Fungus
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Regulation Of Tumor Necrosis Factor Production
Carbohydrate Binding
Negative Regulation Of Inflammatory Response
Defense Response To Symbiont
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Tagcloud (Intersection)
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