HRG and C1QB

Number of citations of the paper that reports this interaction (PMID 9184145)
5

Data Source:
HPRD (in vivo)

		HRG	C1QB
Gene Name		histidine-rich glycoprotein	complement component 1, q subcomponent, B chain
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Platelet Alpha Granule Lumen Endolysosome Phagolysosome Membrane Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Collagen Trimer Complement Component C1 Complex Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding Immunoglobulin Binding Heme Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding	Protein Binding Protein Homodimerization Activity
	Biological Process	Angiogenesis Platelet Degranulation Positive Regulation Of Immune Response To Tumor Cell Chemotaxis Negative Regulation Of Cell Adhesion Blood Coagulation Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Regulation Of Platelet Activation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Endopeptidase Activity Response To Organic Cyclic Compound Negative Regulation Of Angiogenesis Platelet Activation Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Fibrinolysis Positive Regulation Of Apoptotic Process Regulation Of Protein Complex Assembly Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Fungus Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Fibrinolysis Heme Export Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Endothelial Cell Chemotaxis	Complement Activation Complement Activation, Classical Pathway Innate Immune Response Inner Ear Development
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Dissolution of Fibrin Clot Platelet activation, signaling and aggregation	Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881 20303064)
Protein-Protein Interactions		13 interactors: C1QA C1QB CHRD FCGR1A FGA FN1 PLG PLSCR1 RABAC1 RCHY1 SPRY1 THBS1 TNFRSF1A	10 interactors: C1QA C1QC C1R DEFA1 EDA2R HRG IL32 MYOC PTX3 RELA
Entrez ID		3273	713
HPRD ID		00812	00394
Ensembl ID		ENSG00000113905	ENSG00000173369
Uniprot IDs		P04196	P02746
PDB IDs			1PK6 2JG8 2JG9 2WNU 2WNV
Enriched GO Terms of Interacting Partners?		Platelet Activation Platelet Degranulation Defense Response Response To Wounding Blood Coagulation Hemostasis Immune System Process Response To Stress Regulation Of Body Fluid Levels Wound Healing Negative Regulation Of Fibrinolysis Cell Activation Regulation Of Blood Coagulation Exocytosis Phagocytosis, Engulfment Regulation Of Fibrinolysis Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Wound Healing Membrane Invagination Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Inflammatory Response Positive Regulation Of Immune System Process Response To Stimulus Protein Activation Cascade Secretion By Cell Regulation Of Cell-substrate Adhesion Positive Regulation Of Blood Coagulation Regulation Of Endothelial Cell Apoptotic Process Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Acute-phase Response Positive Regulation Of Coagulation Regulation Of Cell Adhesion Secretion Positive Regulation Of Immune Response Peptide Cross-linking Immune Response Positive Regulation Of Wound Healing Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Immune System Process Response To Cytokine Negative Regulation Of Cell-substrate Adhesion Developmental Growth Regulation Of Protein Metabolic Process Negative Regulation Of Blood Coagulation Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Coagulation Vesicle-mediated Transport Negative Regulation Of Wound Healing Innate Immune Response	Defense Response Immune Response Innate Immune Response Response To Fungus Humoral Immune Response Positive Regulation Of Immune Response Immune System Process Response To Stress Regulation Of Immune Response Positive Regulation Of Immune System Process Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Complement Activation Response To Stimulus Protein Activation Cascade Positive Regulation Of Focal Adhesion Assembly Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Positive Regulation Of Adherens Junction Organization Defense Response To Fungus Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Response To Other Organism Leukocyte Mediated Immunity Adaptive Immune Response Response To Biotic Stimulus Regulation Of Focal Adhesion Assembly Positive Regulation Of Cell-matrix Adhesion Regulation Of Cell Junction Assembly ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Acetaldehyde Metabolic Process Cellular Response To Tumor Necrosis Factor ERBB2 Signaling Pathway Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Positive Regulation Of Schwann Cell Differentiation Heme Export Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Exo-alpha-sialidase Activity Regulation Of Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Schwann Cell Differentiation Negative Regulation Of Lamellipodium Assembly Response To Tumor Necrosis Factor Negative Regulation Of Endothelial Cell Chemotaxis Response To Cobalamin Defense Response To Virus Regulation Of Locomotion
Tagcloud ?		absorbed attack c5b c9 complement connected determinant erythrocytes guinea histidine lysis m1 m57 mga name overlapping possesses pyogenes regulon sensitized sepharose serotype serotypes sheep sic streptococcal streptococcus translates virulence	antioxidative atf3 atf4 atf5 axonal believe c1qa c1qc c57bl chac1 chop concurrently crush defense egr1 ganglion glaucoma hmox1 ocular onc optic retinal retinas rgc seq sham srxn1 transcriptome trb3
Tagcloud (Difference) ?		absorbed attack c5b c9 complement connected determinant erythrocytes guinea histidine lysis m1 m57 mga name overlapping possesses pyogenes regulon sensitized sepharose serotype serotypes sheep sic streptococcal streptococcus translates virulence	antioxidative atf3 atf4 atf5 axonal believe c1qa c1qc c57bl chac1 chop concurrently crush defense egr1 ganglion glaucoma hmox1 ocular onc optic retinal retinas rgc seq sham srxn1 transcriptome trb3
Tagcloud (Intersection) ?