HOXD12 and MEIS1

Number of citations of the paper that reports this interaction (PubMedID 9343407)
52

Data Source:
HPRD (in vitro)

		HOXD12	MEIS1
Description		homeobox D12	Meis homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Sequence-specific DNA Binding
	Biological Process	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Embryonic Digit Morphogenesis	Angiogenesis Eye Development Lens Morphogenesis In Camera-type Eye Regulation Of DNA-templated Transcription Brain Development Locomotory Behavior Positive Regulation Of Cell Population Proliferation Embryonic Pattern Specification Animal Organ Morphogenesis Hemopoiesis Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Definitive Hemopoiesis Cell Growth Involved In Cardiac Muscle Cell Development
Pathways			Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Male-pattern baldness ( 28196072)	Adolescent idiopathic scoliosis ( 28334814) Apolipoprotein A1 levels ( 32203549) Chronotype ( 30696823) Coffee consumption ( 31046077) Colorectal cancer (diet interaction) ( 24743840) Early spontaneous preterm birth ( 31194736) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Endometriosis ( 27506219) Femur bone mineral density x serum urate levels interaction ( 34046847) Glaucoma (primary open-angle) ( 29891935) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Insomnia ( 32332799 27992416) Insomnia complaints ( 28604731) Insomnia complaints (continuous) ( 28604731) Insomnia complaints (dichotomous) ( 28604731) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intraocular pressure ( 29785010) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Morning person ( 30696823) Photic sneeze reflex ( 27182965) Platelet count ( 32888494) PR interval ( 20062060 30679814 32439900 21347284 30046033 23139255) PR segment duration ( 24850809) Relative amplitude of rest-activity cycles ( 30120083) Resting heart rate ( 27798624) Restless legs syndrome ( 17637780 33239738 29029846 21779176) Sleep activity levels ( 33075057) Sleep duration ( 30531941) Sleep start time ( 33075057) Sleep traits (multi-trait analysis) ( 27992416) Systolic blood pressure ( 30224653 30578418) Triglycerides ( 30275531) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		17 interacting genes: ACTN3 CABP2 CREBBP DTX2 FGF14 FRS3 MAF MAFB MAFF MAFG MAFK MEIS1 MKRN3 POLR1C TFAP2D TRAF1 TTC19	27 interacting genes: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B
Entrez ID		3238	4211
HPRD ID		00871	03442
Ensembl ID		ENSG00000170178	ENSG00000143995
Uniprot IDs		P35452	O00470
PDB IDs			4XRS 5EGO
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development In Utero Embryonic Development Negative Regulation Of Transcription By RNA Polymerase II Fibroblast Growth Factor Receptor Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Integrated Stress Response Signaling Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Identical Protein Binding Negative Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Rhombomere 6 Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Development Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone H3K27 Acetyltransferase Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Epidermis Development Regulation Of Epidermal Cell Differentiation Abducens Nerve Formation Rhombomere 5 Development Inferior Colliculus Development Sequence-specific Double-stranded DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Bone Mineralization Involved In Bone Maturation Regulation Of Cell Differentiation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Brain Segmentation	Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Anterior/posterior Pattern Specification Chromatin Regionalization Pattern Specification Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Embryonic Skeletal System Morphogenesis Animal Organ Morphogenesis DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Embryonic Morphogenesis Skeletal System Morphogenesis Embryonic Organ Morphogenesis Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anatomical Structure Morphogenesis DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Skeletal System Development Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Animal Organ Development Prostate Gland Development Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Developmental Process Regulation Of Macromolecule Metabolic Process Nucleus Proximal/distal Pattern Formation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Response To Testosterone Sequence-specific DNA Binding Embryonic Limb Morphogenesis System Development Gland Development Limb Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Transcription Regulator Complex Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure
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