HOXD12 and MAF

Number of citations: 0 (PubMedID 11036080)
Data Source: BioGRID (pull down)

		HOXD12	MAF
Name		homeobox D12	MAF bZIP transcription factor
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Chromatin Nucleus Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Skeletal System Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Embryonic Digit Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Lens Development In Camera-type Eye Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Response To Nutrient Gene Expression Positive Regulation Of Gene Expression Megakaryocyte Differentiation Regulation Of Chondrocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Inner Ear Development Lens Fiber Cell Differentiation Integrated Stress Response Signaling
Pathways		None	RUNX2 regulates osteoblast differentiation
Diseases		None	Multiple myeloma
GWAS		Digit length ratio ( 29659830 ) Digit length ratio (left hand) ( 29659830 ) Digit length ratio (right hand) ( 29659830 ) Male-pattern baldness ( 28196072 )	Alanine aminotransferase levels ( 34315874 33547301 ) Alzheimer's disease (late onset) ( 30820047 ) Apolipoprotein B levels ( 32203549 ) Aspartate aminotransferase levels ( 34315874 33547301 ) Colorectal cancer ( 31826910 30529582 ) Depressive symptoms (SSRI exposure interaction) ( 25649181 ) Estimated glomerular filtration rate ( 31015462 ) Height ( 20668459 ) High density lipoprotein cholesterol levels ( 33339817 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Lysophosphatidylcholine levels ( 31551469 ) Macular thickness ( 30535121 ) Metabolite levels ( 23823483 ) Multiple sclerosis ( 24076602 21833088 31604244 ) Obesity ( 19151714 ) Paclitaxel disposition in epithelial ovarian cancer ( 29367611 ) Refractive error ( 32231278 ) Renal function-related traits (urate) ( 22797727 ) Response to fenofibrate (HDL cholesterol levels) ( 27002377 ) Serum alkaline phosphatase levels ( 29403010 33547301 33339817 ) Serum thyroid-stimulating hormone levels ( 24852370 ) Serum uric acid levels ( 30993211 ) Spherical equivalent or myopia (age of diagnosis) ( 29808027 ) Thyroid function ( 22494929 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 25743335 ) Thyroid volume ( 21565293 ) Triglyceride levels ( 32203549 ) Urate levels ( 31985003 23263486 ) Vitamin C levels ( 33203707 )
Novel Interactors		None recorded	1 novel interactors: NEU1
Interacting Genes		17 interacting genes: ACTN3 CABP2 CREBBP DTX2 FGF14 FRS3 MAF MAFB MAFF MAFG MAFK MEIS1 MKRN3 POLR1C TFAP2D TRAF1 TTC19	16 interacting genes: ATF4 CREBBP EP300 ETS1 FOS FOSL1 HOXD12 JUN MAFA MAFB MAFG MYB SMARCA5 SOX9 UBE2O USF2
Entrez ID		3238	4094
HPRD ID		00871	01518
Ensembl ID		ENSG00000170178	ENSG00000178573
Uniprot IDs		P35452	H3BP11 O75444
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Chordate Embryonic Development In Utero Embryonic Development Negative Regulation Of Transcription By RNA Polymerase II Fibroblast Growth Factor Receptor Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Integrated Stress Response Signaling Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Identical Protein Binding Negative Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Rhombomere 6 Development Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Multicellular Organismal Development Regulation Of The Force Of Skeletal Muscle Contraction Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone H3K27 Acetyltransferase Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Epidermis Development Regulation Of Epidermal Cell Differentiation Abducens Nerve Formation Rhombomere 5 Development Inferior Colliculus Development Sequence-specific Double-stranded DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Bone Mineralization Involved In Bone Maturation Regulation Of Cell Differentiation Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Brain Segmentation	Sequence-specific Double-stranded DNA Binding Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Transcription Regulator Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Regulation Of MiRNA Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of MiRNA Metabolic Process Integrated Stress Response Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Transcription Regulation Of RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Intracellular Signaling Cassette Histone H3K27 Acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleus Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Sequence-specific DNA Binding Cellular Response To Nutrient Levels Transcription Cis-regulatory Region Binding Chromatin Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Response To Nutrient Levels