HOXC4 and PRKDC

Number of citations of the paper that reports this interaction (PMID 11279128)
11

Data Source:
HPRD (in vitro, in vivo)

		HOXC4	PRKDC
Gene Name		homeobox C4	protein kinase, DNA-activated, catalytic polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleoplasm Transcription Factor Complex Nucleolus Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Nonhomologous End Joining Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding HMG Box Domain Binding	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Enzyme Binding Poly(A) RNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Anterior/posterior Pattern Specification Embryonic Organ Morphogenesis Cartilage Development	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Somitogenesis Negative Regulation Of Protein Phosphorylation B Cell Lineage Commitment Pro-B Cell Differentiation T Cell Lineage Commitment DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cellular Protein Modification Process Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Peptidyl-serine Phosphorylation Protein Destabilization Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Ectopic Germ Cell Programmed Cell Death Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Pathways			Nonhomologous End-joining (NHEJ) Cytosolic sensors of pathogen-associated DNA Processing of DNA ends prior to end rejoining STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: ELMOD2 HTT NCK2 PRKDC PRMT5 PRMT6 RNF32 SOX10 SUV39H1 WHSC1L1 XRCC6	83 interactors: ABL1 AICDA AKT1 AKT2 AP1B1 ATM ATRIP BRCA1 C1D CASP3 CHEK1 CHEK2 CHUK CIB1 CTDP1 DCLRE1C E4F1 EIF2S2 EIF4EBP1 ERG GSK3A GSK3B GZMB H2AFX HDAC3 HIST1H1A HIST1H1C HMGB1 HMGB2 HNRNPA1 HNRNPC HOXC4 HSF1 HSP90AA1 IKBKB ILF2 JUN KAT2A LIG4 LYN MAPK8 MBP MKNK1 MRE11A NBN NCF1 NCF2 NCF4 NCOA6 NR3C1 PARP1 PCNA PDX1 PGR POU2F1 PPP6C PPP6R1 PPP6R2 PPP6R3 PRKCD PTS RAD17 RBBP8 RNF144A RPA1 RPA2 SGOL1 SP1 SRF THRA THRB TP53 TREX1 UBC USF1 VPRBP WRN XPA XRCC4 XRCC5 XRCC6 YWHAG YWHAQ
Entrez ID		3221	5591
HPRD ID		00860	02941
Ensembl ID		ENSG00000273266	ENSG00000253729
Uniprot IDs		P09017 Q86TF7	P78527
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone Methylation Negative Regulation Of Cellular Metabolic Process Protein Methylation Chromosome Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organelle Organization Negative Regulation Of Gene Expression Rhythmic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Histone H4-R3 Methylation Regulation Of Metabolic Process Histone Modification Methylation Peptidyl-arginine N-methylation Peptidyl-amino Acid Modification Histone Arginine Methylation Double-strand Break Repair Via Nonhomologous End Joining Peptidyl-arginine Methylation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process V(D)J Recombination Chromatin Modification Heterocycle Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription, DNA-templated Chromatin Organization RNA Biosynthetic Process Positive Regulation Of Gene Expression Nitrogen Compound Metabolic Process Cellular Response To DNA Damage Stimulus Neural Plate Formation Telomere Maintenance Central Nervous System Development Positive Regulation Of Type I Interferon Production Positive Regulation Of Transcription From RNA Polymerase II Promoter Histone Lysine Methylation Nucleobase-containing Compound Metabolic Process Peptidyl-lysine Methylation Response To Radiation Regulation Of Circadian Rhythm Response To Abiotic Stimulus RNA Metabolic Process Histone H3-R2 Methylation	Cellular Response To Stress DNA Repair Cellular Response To DNA Damage Stimulus DNA Recombination DNA Metabolic Process Double-strand Break Repair Response To Stress Immune System Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Response To Abiotic Stimulus Positive Regulation Of Metabolic Process Cellular Response To Stimulus Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Immune System Development Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cell Cycle Cellular Response To Organic Substance Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process Organelle Organization Cellular Metabolic Process Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Process Cell Death Death Telomere Maintenance Developmental Process Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway DNA Damage Checkpoint Cellular Macromolecule Biosynthetic Process Response To Stimulus Mitotic Cell Cycle Macromolecule Biosynthetic Process Response To Radiation Organ Development Mitotic Cell Cycle Process
Tagcloud ?		125b 181b 19a 20a 23b 30a aicda autoantibody bach2 bcl6 blimp csr cytidine dampened deaminase hypermutated hypermutation irf4 lpr mrl pax5 prdm1 rev1 shm silence switched underpin ung valproic	1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic il2rg loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Difference) ?		125b 181b 19a 20a 23b 30a aicda autoantibody bach2 bcl6 blimp csr cytidine dampened deaminase hypermutated hypermutation irf4 lpr mrl pax5 prdm1 rev1 shm silence switched underpin ung valproic	1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic il2rg loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Intersection) ?