HOXC4 and CLK3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOXC4	CLK3
Description		homeobox C4	CDC like kinase 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Membrane Nuclear Speck Cytoplasmic Vesicle Intermediate Filament Cytoskeleton
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Skeletal System Development Regulation Of DNA-templated Transcription Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Morphogenesis Embryonic Skeletal System Morphogenesis Cartilage Development	Protein Phosphorylation Regulation Of RNA Splicing
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs			K-00546 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib
Diseases
GWAS		A body shape index ( 34021172) Coronary artery disease ( 32469254) Diastolic blood pressure ( 27841878) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Pulse pressure ( 30578418 27841878) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Systolic blood pressure ( 30578418 27841878 27618447) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549) Waist circumference ( 28552196) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28552196 28448500 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Bladder cancer ( 25281661) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Celiac disease ( 22057235) Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712)
Interacting Genes		18 interacting genes: APP CLK3 CSNK2A1 ELMOD2 EXOSC5 HTT NCK2 NSD3 PRKDC PRMT5 PRMT6 RCHY1 RNF32 RPRD1B SOX10 SUV39H1 TSN XRCC6	43 interacting genes: APP CHERP CLASRP CLK2 DDIT4L EIF4ENIF1 HNRNPR HOXB6 HOXB7 HOXC4 INCA1 KRTAP10-3 LNX1 NEDD4 NKAPL NXF1 OAS2 PRMT5 RBMX RBMY1A1 RBMY1F RNF8 RNPS1 RSRP1 SAG SDCBP SH2B2 SLAMF7 SNRNP35 SRPK2 SRSF1 SRSF10 SRSF3 SRSF8 SUV39H1 TINF2 TRA2B USP13 YWHAG ZNF263 ZNF473 ZNF777 ZNF835
Entrez ID		3221	1198
HPRD ID		00860	04290
Ensembl ID		ENSG00000198353	ENSG00000179335
Uniprot IDs		P09017 Q86TF7	B3KRI8 P49761
PDB IDs			2EU9 2EXE 2WU6 2WU7 3RAW 6FT7 6FYP 6FYR 6KHF 6RCT 6YTW 6YTY 6YU1 6Z2V 6Z51 6Z52 6Z53 6Z54 6Z55 9EZ3
Enriched GO Terms of Interacting Partners?		Histone H3 Methyltransferase Activity Histone Methyltransferase Activity Nucleic Acid Metabolic Process Nucleoplasm Regulation Of Metabolic Process Histone Arginine N-methyltransferase Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Aggrephagy DNA-dependent Protein Kinase Complex Histone H4R3 Methyltransferase Activity Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process DNA-dependent Protein Kinase-DNA Ligase 4 Complex Negative Regulation Of Biosynthetic Process Methyltransferase Activity Nonhomologous End Joining Complex Double-strand Break Repair Via Nonhomologous End Joining Chromatin Remodeling RNA Metabolic Process Protein-arginine N-methyltransferase Activity Methylation P53 Binding Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA Damage Response Positive Regulation Of Protein Metabolic Process Rhythmic Process Macromolecule Metabolic Process Chromatin Organization DNA Repair Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cellular Response To Stress Transferase Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Identical Protein Binding Positive Regulation Of RNA Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Post-transcriptional Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process	Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Processing RNA Splicing Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process MRNA Binding RNA Processing MRNA Metabolic Process Nucleic Acid Binding Positive Regulation Of RNA Splicing RNA Metabolic Process Nucleus Nucleoplasm RNA Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Spliceosomal Complex MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Nuclear Speck Positive Regulation Of MRNA Metabolic Process Negative Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Splicing RS Domain Binding Protein-RNA Complex Assembly Positive Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Pre-mRNA Binding Identical Protein Binding Embryonic Skeletal System Morphogenesis Exon-exon Junction Complex
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