ADGRE5 and GCC1

		ADGRE5	GCC1
Description		adhesion G protein-coupled receptor E5	GRIP and coiled-coil domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Focal Adhesion Membrane Secretory Granule Membrane Extracellular Exosome	Golgi Trans Cisterna Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Calcium Ion Binding Protein Binding	Protein Binding Small GTPase Binding
	Biological Process	Immune System Process Inflammatory Response Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling
Pathways		Class B/2 (Secretin family receptors) Neutrophil degranulation	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS			Feeling worry ( 29500382) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Medication adherence in chronic diseases ( 25317111) Refractive error ( 32231278) Type 2 diabetes ( 22158537 26818947 30718926)
Interacting Genes		3 interacting genes: CD55 HNRNPD XRN1	66 interacting genes: ABI2 AMOTL2 APP ARL1 ATF4 ATN1 BIRC2 BRCA1 C1orf94 CCDC33 CCDC85B CEP57 CEP70 COIL CPSF7 DISC1 DNAJA3 DRC4 FAM83A FBF1 FBXO28 FIGNL1 FOSL1 GLI1 GOLGA2 GTF2I HDX ICA1L IKBKG ITSN1 KATNAL1 KDM1A KIAA0753 KIAA1217 KIF5B LCA5 LZTS2 MCRS1 MED4 MEOX1 MID2 NAB2 NAV1 NECAB2 NINL OIP5 PAK5 PPP1R18 PPP1R27 PRPF18 RUNX1 SMARCA2 SMARCD1 SPOP TFIP11 TLE5 TP53BP2 TRIM29 TRIM50 TSC1 USHBP1 UTP14C XIAP ZC4H2 ZFP90 ZNF276
Entrez ID		976	79571
HPRD ID		03130	07599
Ensembl ID		ENSG00000123146	ENSG00000179562
Uniprot IDs		P48960	A4D0Z4 Q96CN9
PDB IDs		2BOU 7DO4 7YDH 7YDJ 7YDM 7YDP 8IKJ 8IKL
Enriched GO Terms of Interacting Partners?		Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Hepatocyte Dedifferentiation Regulation Of Telomere Maintenance Cellular Response To Putrescine Regulation Of DNA Biosynthetic Process Cellular Response To Puromycin Cellular Response To Cycloheximide Circadian Regulation Of Translation Response To Rapamycin RNA Catabolic Process Positive Regulation Of Telomere Capping Cell Dedifferentiation MCRD-mediated MRNA Stability Complex Response To Ketone Regulation Of Chromosome Organization Response To Alcohol Response To Cycloheximide 5'-3' RNA Exonuclease Activity G-quadruplex RNA Binding Golgi Trans Cisterna Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding G-quadruplex DNA Binding Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Nucleobase-containing Compound Catabolic Process CRD-mediated MRNA Stabilization 5'-3' Exonuclease Activity Nuclear MRNA Surveillance Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Complement Activation Regulation Of Telomere Capping Regulation Of Translation Histone MRNA Catabolic Process Cellular Response To Nitric Oxide RRNA Catabolic Process Positive Regulation Of Cytoplasmic Translation 3'-UTR-mediated MRNA Destabilization Cellular Response To Reactive Nitrogen Species Regulation Of Complement Activation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Respiratory Burst Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of DNA Metabolic Process Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Telomere Maintenance Via Telomerase Response To Salt Response To Nitric Oxide Response To Ether	Identical Protein Binding Protein Binding Cytoskeleton Microtubule Centrosome Microtubule Severing Transcription Coactivator Activity Microtubule-based Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoplasm Regulation Of DNA Repair Microtubule Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process P53 Binding Microtubule Severing ATPase Activity Regulation Of Primary Metabolic Process Lens Fiber Cell Morphogenesis Ciliary Basal Body Regulation Of Cellular Response To Stress Regulation Of Double-strand Break Repair Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Manganese Ion Spindle Pole Cytoplasm Organization Microtubule Cytoskeleton Organization Nucleus Negative Regulation Of DNA-templated Transcription Regulation Of Growth Negative Regulation Of RNA Biosynthetic Process Spermatid Development
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