PPOX

Description		protoporphyrinogen oxidase
Image
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Membrane
	Molecular Function	Oxygen-dependent Protoporphyrinogen Oxidase Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Porphyrin-containing Compound Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Xenobiotic Stimulus Protoporphyrinogen IX Metabolic Process Heme O Biosynthetic Process
Pathways		Heme biosynthesis
Drugs
Diseases		Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS
Interacting Genes		4 interacting genes: COPS5 HAP1 HNRNPD IMMT
Entrez ID		5498
HPRD ID		02953
Ensembl ID		ENSG00000143224
Uniprot IDs		B4DY76 P50336
PDB IDs		3NKS 4IVM 4IVO
Enriched GO Terms of Interacting Partners?		Cerebellum Development Hepatocyte Dedifferentiation Cellular Response To Putrescine Positive Regulation Of Neurotrophin Production Establishment Of Vesicle Localization Vesicle Localization Circadian Regulation Of Translation Synaptic Vesicle Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Macrophage Migration Inhibitory Factor Binding Synapse Brain-derived Neurotrophic Factor Binding Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Exocytosis Exosomal Secretion Response To Rapamycin Positive Regulation Of Telomere Capping Cell Dedifferentiation MCRD-mediated MRNA Stability Complex Establishment Of Organelle Localization Hypothalamus Cell Differentiation DeNEDDylase Activity Mitochondrial Crista Junction MICOS Complex Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Non-motile Cilium Assembly CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Protein Metabolic Process Regulation Of Non-motile Cilium Assembly Protein Deneddylation Metal-dependent Deubiquitinase Activity SAM Complex Cristae Formation MIB Complex Secretion By Cell Cellular Response To Nitric Oxide Positive Regulation Of Cytoplasmic Translation 3'-UTR-mediated MRNA Destabilization Regulation Of Telomere Capping Cellular Response To Reactive Nitrogen Species Organelle Localization Positive Regulation Of Synaptic Transmission, GABAergic Mitochondrion Distribution Neurotrophin TRK Receptor Signaling Pathway Regulation Of IRE1-mediated Unfolded Protein Response Eukaryotic Translation Initiation Factor 3 Complex Mitochondrial Envelope
Tagcloud ?