PPOX

Gene Name		protoporphyrinogen oxidase
Image
Gene Ontology Annotations	Cellular Component	Mitochondrial Intermembrane Space Intrinsic Component Of Mitochondrial Inner Membrane Integral Component Of Mitochondrial Inner Membrane Mitochondrial Membrane
	Molecular Function	Oxygen-dependent Protoporphyrinogen Oxidase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Porphyrin-containing Compound Metabolic Process Porphyrin-containing Compound Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Response To Drug Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Heme biosynthesis Metabolism of porphyrins
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: COPS5 HAP1 HNRNPD IMMT
Entrez ID		5498
HPRD ID		02953
Ensembl ID		ENSG00000143224
Uniprot IDs		B3KT30 B4DY76 P50336
PDB IDs		3NKS 4IVM 4IVO
Enriched GO Terms of Interacting Partners?		Regulation Of MRNA Stability Regulation Of RNA Stability Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cilium Assembly Exosomal Secretion Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Circadian Regulation Of Translation Exocytosis Cullin Deneddylation Hypothalamus Cell Differentiation Negative Regulation Of Beta-amyloid Formation Protein Deneddylation Retrograde Axon Cargo Transport Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Microtubule-based Movement Positive Regulation Of Synaptic Transmission, GABAergic Secretion By Cell Nucleotide-excision Repair, DNA Gap Filling Negative Regulation Of Smooth Muscle Cell Migration Mitochondrial Calcium Ion Homeostasis DNA Demethylation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Telomere Maintenance Via Semi-conservative Replication Transcription, DNA-templated Regulation Of Beta-amyloid Formation Regulation Of Cilium Assembly RNA Biosynthetic Process Nuclear DNA Replication Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Amyloid Precursor Protein Catabolic Process Telomere Maintenance Via Recombination Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Secretion Hypothalamus Development Positive Regulation Of Organelle Assembly Positive Regulation Of Cell Cycle G1/S Phase Transition Anterograde Axon Cargo Transport Positive Regulation Of Cellular Metabolic Process Mitotic Recombination DNA Strand Elongation Involved In DNA Replication Cellular Homeostasis DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cation Channel Activity
Tagcloud ?		1082dupc ahp ahps aip biosynthetic cancerous catalyzing complication g111r germline hcc hccs heme hit hmbs hydroxymethylbilane intermittent l220x l416x oxidase pathomechanisms porphyria porphyrias protoporphyrinogen respective somatic suppressors variegate vp