PPOX and IMMT

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PPOX	IMMT
Description		protoporphyrinogen oxidase	inner membrane mitochondrial protein
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Membrane	SAM Complex Mitochondrion Mitochondrial Envelope Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Membrane Mitochondrial Crista Junction MICOS Complex MIB Complex
	Molecular Function	Oxygen-dependent Protoporphyrinogen Oxidase Activity Oxidoreductase Activity Flavin Adenine Dinucleotide Binding	RNA Binding Protein Binding
	Biological Process	Porphyrin-containing Compound Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Response To Xenobiotic Stimulus Protoporphyrinogen IX Metabolic Process Heme O Biosynthetic Process	Inner Mitochondrial Membrane Organization Cristae Formation Mitochondrial Calcium Ion Homeostasis Neuron Cellular Homeostasis
Pathways		Heme biosynthesis	Cristae formation
Drugs
Diseases		Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS			Facial emotion recognition (sad faces) ( 28608620) Night sleep phenotypes ( 27126917)
Interacting Genes		4 interacting genes: COPS5 HAP1 HNRNPD IMMT	65 interacting genes: AKTIP ALB ANTKMT ARMCX3 ASCC2 ATXN1 BAG6 BMI1 C10orf88 C8orf33 CALM1 CCT5 CDC37 CFAP263 CHD3 CSTF2 DISC1 DSCR9 ECSIT EEF1A1 EP300 EXOSC10 FEZ1 FUBP1 HAP1 HIVEP1 HJURP HMOX2 HNRNPD HTRA2 KDM1A KIF22 KPNA2 LRIF1 MARCHF5 MRPL44 NDEL1 NDUFB9 NEK2 NIPSNAP3A NOS3 NRIP1 PDE4B PFDN1 PIAS4 PLA2G15 PPOX PRRC2A RER1 RNF10 RNF26 SDHAF2 SMN1 SNAPIN SRRT STMN4 STX5 TAF1D TK1 TNNT1 TRAF3IP1 TUBGCP3 TXNDC9 UBC UBQLN4
Entrez ID		5498	10989
HPRD ID		02953	02658
Ensembl ID		ENSG00000143224	ENSG00000132305
Uniprot IDs		B4DY76 P50336	B4DS66 C9J406 Q16891
PDB IDs		3NKS 4IVM 4IVO
Enriched GO Terms of Interacting Partners?		Cerebellum Development Hepatocyte Dedifferentiation Cellular Response To Putrescine Positive Regulation Of Neurotrophin Production Establishment Of Vesicle Localization Vesicle Localization Circadian Regulation Of Translation Synaptic Vesicle Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Macrophage Migration Inhibitory Factor Binding Synapse Brain-derived Neurotrophic Factor Binding Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Exocytosis Exosomal Secretion Response To Rapamycin Positive Regulation Of Telomere Capping Cell Dedifferentiation MCRD-mediated MRNA Stability Complex Establishment Of Organelle Localization Hypothalamus Cell Differentiation DeNEDDylase Activity Mitochondrial Crista Junction MICOS Complex Response To Sodium Phosphate Minor Groove Of Adenine-thymine-rich DNA Binding Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Non-motile Cilium Assembly CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Protein Metabolic Process Regulation Of Non-motile Cilium Assembly Protein Deneddylation Metal-dependent Deubiquitinase Activity SAM Complex Cristae Formation MIB Complex Secretion By Cell Cellular Response To Nitric Oxide Positive Regulation Of Cytoplasmic Translation 3'-UTR-mediated MRNA Destabilization Regulation Of Telomere Capping Cellular Response To Reactive Nitrogen Species Organelle Localization Positive Regulation Of Synaptic Transmission, GABAergic Mitochondrion Distribution Neurotrophin TRK Receptor Signaling Pathway Regulation Of IRE1-mediated Unfolded Protein Response Eukaryotic Translation Initiation Factor 3 Complex Mitochondrial Envelope	Centrosome Cytoplasm Cytosol Microtubule-based Process Protein Binding Protein-containing Complex Nucleoplasm Organelle Organization Retrograde Axonal Transport Axon Cytoplasm Axonal Transport Synaptic Vesicle Nucleus Organelle Localization Cytoskeleton Internal Peptidyl-lysine Acetylation Mitochondrion Microtubule Gamma-tubulin Binding Axo-dendritic Transport Organelle Transport Along Microtubule Negative Regulation Of Macroautophagy Radial Glia-guided Pyramidal Neuron Migration Protein Localization To Perinuclear Region Of Cytoplasm Nuclear Body Regulation Of Protein Metabolic Process RNA Binding Regulation Of Organelle Transport Along Microtubule Transport Along Microtubule Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA Metabolic Process Internal Protein Amino Acid Acetylation Regulation Of Telomere Maintenance Via Telomerase Kinesin Complex Vesicle Transport Along Microtubule Regulation Of Metabolic Process Negative Regulation Of Autophagy Catabolic Process Gamma-tubulin Complex Regulation Of Telomere Maintenance Centrosome Separation Unfolded Protein Binding Regulation Of Telomerase RNA Localization To Cajal Body Cytoskeleton-dependent Intracellular Transport
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