ANP32B and PMS2

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		ANP32B	PMS2
Description		acidic nuclear phosphoprotein 32 family member B	PMS1 homolog 2, mismatch repair system component
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Cytosol Mismatch Repair Complex MutLalpha Complex
	Molecular Function	Protein Binding Histone Binding RNA Polymerase Binding	Nucleotide Binding DNA Binding Single-stranded DNA Binding Nuclease Activity Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Mismatched DNA Binding Single Base Insertion Or Deletion Binding MutSalpha Complex Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Vasculature Development Nucleosome Assembly Ventricular System Development Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Protein Export From Nucleus Inner Ear Development Roof Of Mouth Development	DNA Repair Mismatch Repair DNA Damage Response Response To Xenobiotic Stimulus Somatic Hypermutation Of Immunoglobulin Genes Somatic Recombination Of Immunoglobulin Gene Segments Positive Regulation Of Isotype Switching To IgA Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes
Pathways			Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MLH1 Defective Mismatch Repair Associated With PMS2 TP53 Regulates Transcription of DNA Repair Genes
Drugs			Adenosine 5'-[gamma-thio]triphosphate
Diseases			Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
GWAS		Alopecia areata ( 25608926) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Immature fraction of reticulocytes ( 27863252) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 27863252 32888494) Serum thyroid-stimulating hormone levels ( 25436638)
Interacting Genes		42 interacting genes: AIM2 APC APP AURKA BAX BCL10 BEND7 BUB1 CHAF1A CSNK2A1 DCC DNTTIP1 ELAVL1 ESR1 FAM217B FAM3A FBXW7 H2AC1 H2BC1 H3C1 H4C1 HNF4A KLF5 KPNA1 KPNA5 MCC MEOX2 MLH3 MYNN PMS2 POLR1A PTEN PTPN12 PTPRJ SDCBP SMAD2 SMARCD1 STK11 TLR2 UCHL5 XPO1 YAF2	18 interacting genes: AKT1 ANP32B CCDC180 CRYAA EXO1 FANCC GALNT12 MEOX2 MLH1 PCNA PPP2CB RASA1 SFRP4 TRMO UBC VPS26C XPA ZNF189
Entrez ID		10541	5395
HPRD ID		09803	02598
Ensembl ID		ENSG00000136938	ENSG00000122512
Uniprot IDs		Q92688	A0A2R8Y6S3 A0A8V8TNX6 A0A8V8TNY8 A0A8V8TP61 A0A8V8TP84 A0A8V8TPE1 A0A8V8TQ50 A0A8V8TQ92 A0A8V8TQG9 A0A8V8TQI1 A0A8V8TQS5 B4DGM0 C9J167 P54278
PDB IDs		2ELL 2RR6 8R1J 8R1L	1EA6 1H7S 1H7U 5U5R 6MFQ 7RCB 7RCI 7RCK
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Chromatin Remodeling Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Protein Heterodimerization Activity Regulation Of Macromolecule Metabolic Process Developmental Growth DNA Binding Chromatin Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Regulation Of Primary Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Signal Transduction Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Death Regulation Of Wnt Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Communication DNA Damage Response Regulation Of Signaling Microglia Development Satellite Cell Activation Involved In Skeletal Muscle Regeneration Nucleosome Organization Chromatin Binding Chromosome Organization Protein Localization To Organelle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Regulation Of Proteolysis Negative Regulation Of Metabolic Process Cytosol Apoptotic Process Regulation Of Gene Expression Kinetochore Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Population Proliferation Structural Constituent Of Chromatin Mismatch Repair Complex Positive Regulation Of RNA Metabolic Process Protein Dephosphorylation	Response To Oxidative Stress Positive Regulation Of Deoxyribonuclease Activity Mismatch Repair Response To UV Response To UV-A Somatic Hypermutation Of Immunoglobulin Genes Somatic Diversification Of Immune Receptors Via Somatic Mutation Response To Hydrogen Peroxide DNA Repair Response To Light Stimulus Isotype Switching Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Somatic Diversification Of Immunoglobulins Involved In Immune Response Cellular Response To Stress Enzyme Binding TRNA Methylation Nucleus Regulation Of TRNA Methylation Response To Radiation Response To Reactive Oxygen Species DNA Metabolic Process DNA Damage Response Somatic Recombination Of Immunoglobulin Gene Segments Somatic Cell DNA Recombination Late Recombination Nodule Somatic Diversification Of Immunoglobulins Meiotic Metaphase I Homologous Chromosome Alignment PCNA Complex Replisome Negative Regulation Of Sodium-dependent Phosphate Transport Nucleotide-excision Repair, DNA Damage Recognition Double-stranded DNA 5'-3' DNA Exonuclease Activity TRNA (L-threonylcarbamoyladenosine(37)-C2) Methyltransferase Activity Male Germ Cell Nucleus Nucleotide-excision Repair
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