ANP32B and KLF5

Number of citations of the paper that reports this interaction (PubMedID 18039846)
53

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		ANP32B	KLF5
Description		acidic nuclear phosphoprotein 32 family member B	KLF transcription factor 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Extracellular Exosome	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Golgi Apparatus
	Molecular Function	Protein Binding Histone Binding RNA Polymerase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding MRF Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Vasculature Development Nucleosome Assembly Ventricular System Development Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Protein Export From Nucleus Inner Ear Development Roof Of Mouth Development	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Skeletal Muscle Satellite Cell Differentiation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Myotube Differentiation Involved In Skeletal Muscle Regeneration Microvillus Assembly Regulation Of Microvillus Assembly Skeletal Muscle Cell Differentiation Skeletal Muscle Tissue Regeneration Positive Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Intestinal Epithelial Cell Development Positive Regulation Of Transcription By Transcription Factor Localization Cellular Response To Leukemia Inhibitory Factor Cellular Response To Endothelin
Pathways			Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Immature fraction of reticulocytes ( 27863252) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 27863252 32888494) Serum thyroid-stimulating hormone levels ( 25436638)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29679657) Aspartate aminotransferase levels ( 33547301) Asthma ( 34103634) Blood urea nitrogen levels ( 31152163) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast Cancer in BRCA1 mutation carriers ( 29058716) Chronotype ( 30696823) Colorectal cancer ( 30529582) Colorectal cancer or advanced adenoma ( 30510241) Creatine kinase levels ( 29403010) Endometrial cancer ( 27008869 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29785010 31959993) Keratoconus ( 33649486) Lymphocyte percentage of white cells ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte count ( 32888494) Neutrophil count ( 32888494) Pancreatic cancer ( 20101243 29422604 26098869 25086665) Prostate cancer ( 26443449 31562322) Systolic blood pressure ( 30224653) Type 2 diabetes ( 25760438)
Interacting Genes		42 interacting genes: AIM2 APC APP AURKA BAX BCL10 BEND7 BUB1 CHAF1A CSNK2A1 DCC DNTTIP1 ELAVL1 ESR1 FAM217B FAM3A FBXW7 H2AC1 H2BC1 H3C1 H4C1 HNF4A KLF5 KPNA1 KPNA5 MCC MEOX2 MLH3 MYNN PMS2 POLR1A PTEN PTPN12 PTPRJ SDCBP SMAD2 SMARCD1 STK11 TLR2 UCHL5 XPO1 YAF2	26 interacting genes: ANP32B ATXN3L CREBBP EP300 ESR1 FBXW7 GSK3B GTF2B GTF2E2 GTF2F2 HDAC1 JUN NCOR1 NCOR2 NEDD4 NFKB1 PARP1 PPARG PRKCA PRKCD RARA RXRA SET SMURF2 TBP UBE2I
Entrez ID		10541	688
HPRD ID		09803	04212
Ensembl ID		ENSG00000136938	ENSG00000102554
Uniprot IDs		Q92688	Q13887 Q5T6X2
PDB IDs		2ELL 2RR6 8R1J 8R1L	2EBT
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Chromatin Remodeling Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Protein Heterodimerization Activity Regulation Of Macromolecule Metabolic Process Developmental Growth DNA Binding Chromatin Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Regulation Of Primary Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Signal Transduction Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Death Regulation Of Wnt Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Communication DNA Damage Response Regulation Of Signaling Microglia Development Satellite Cell Activation Involved In Skeletal Muscle Regeneration Nucleosome Organization Chromatin Binding Chromosome Organization Protein Localization To Organelle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Regulation Of Proteolysis Negative Regulation Of Metabolic Process Cytosol Apoptotic Process Regulation Of Gene Expression Kinetochore Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Population Proliferation Structural Constituent Of Chromatin Mismatch Repair Complex Positive Regulation Of RNA Metabolic Process Protein Dephosphorylation	Nucleoplasm Transcription By RNA Polymerase II Enzyme Binding DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Chromatin Negative Regulation Of Biosynthetic Process Nucleus Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Transcription Regulator Complex Regulation Of MiRNA Metabolic Process Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Primary Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Nucleobase-containing Compound Biosynthetic Process Regulation Of MiRNA Transcription Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Cellular Response To UV DNA Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Transcription Coregulator Binding Protein-containing Complex Response To Lipid Positive Regulation Of Protein Localization Cellular Response To Light Stimulus Transcription Coactivator Binding
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