ANP32B and BCL10

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		ANP32B	BCL10
Description		acidic nuclear phosphoprotein 32 family member B	BCL10 immune signaling adaptor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Extracellular Exosome	Immunological Synapse Polkadots Nucleus Nucleoplasm Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule Membrane CBM Complex Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Histone Binding RNA Polymerase Binding	Protease Binding Transcription Coactivator Activity Protein Binding Kinase Activator Activity Protein-macromolecule Adaptor Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Kinase B Binding Protein-containing Complex Binding CARD Domain Binding NF-kappaB Binding General Transcription Initiation Factor Binding
	Biological Process	Vasculature Development Nucleosome Assembly Ventricular System Development Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Protein Export From Nucleus Inner Ear Development Roof Of Mouth Development	B Cell Apoptotic Process Positive Regulation Of Cytokine Production Neural Tube Closure Toll-like Receptor Signaling Pathway Adaptive Immune Response Immune System Process Negative Regulation Of Mature B Cell Apoptotic Process Apoptotic Process Cellular Defense Response Response To Fungus Programmed Cell Death Immunoglobulin Mediated Immune Response Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Response To Food Response To Lipopolysaccharide Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of Mast Cell Cytokine Production Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Antifungal Innate Immune Response T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Coronary artery disease ( 29212778) Eosinophil count ( 32888494) Immature fraction of reticulocytes ( 27863252) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Red blood cell count ( 27863252 32888494) Serum thyroid-stimulating hormone levels ( 25436638)	Metabolite levels ( 23823483) Multiple sclerosis ( 24076602)
Interacting Genes		42 interacting genes: AIM2 APC APP AURKA BAX BCL10 BEND7 BUB1 CHAF1A CSNK2A1 DCC DNTTIP1 ELAVL1 ESR1 FAM217B FAM3A FBXW7 H2AC1 H2BC1 H3C1 H4C1 HNF4A KLF5 KPNA1 KPNA5 MCC MEOX2 MLH3 MYNN PMS2 POLR1A PTEN PTPN12 PTPRJ SDCBP SMAD2 SMARCD1 STK11 TLR2 UCHL5 XPO1 YAF2	45 interacting genes: AKT1 ANP32B ATM BAAT CARD10 CARD11 CARD14 CARD19 CARD9 CASP9 CCDC180 CDC14B CDK9 CHUK COG6 FBP1 HEMGN IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NANS NHERF1 NLRC4 OTULIN PELI2 PRRG4 RASA1 RIPK2 RNF181 SLC20A1 SOCS3 SRSF1 TGFB1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 TRMO UBE2N UBE2V2 USHBP1
Entrez ID		10541	8915
HPRD ID		09803	04625
Ensembl ID		ENSG00000136938	ENSG00000142867
Uniprot IDs		Q92688	A0A087WWW9 A2TDT2 O95999
PDB IDs		2ELL 2RR6 8R1J 8R1L	2MB9 6BZE 6GK2 8CZD 8CZO
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Chromatin Remodeling Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Protein Heterodimerization Activity Regulation Of Macromolecule Metabolic Process Developmental Growth DNA Binding Chromatin Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Regulation Of Primary Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Signal Transduction Programmed Cell Death Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cell Death Regulation Of Wnt Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Communication DNA Damage Response Regulation Of Signaling Microglia Development Satellite Cell Activation Involved In Skeletal Muscle Regeneration Nucleosome Organization Chromatin Binding Chromosome Organization Protein Localization To Organelle Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Population Proliferation Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Protein Catabolic Process Regulation Of Cellular Component Organization Regulation Of Proteolysis Negative Regulation Of Metabolic Process Cytosol Apoptotic Process Regulation Of Gene Expression Kinetochore Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Population Proliferation Structural Constituent Of Chromatin Mismatch Repair Complex Positive Regulation Of RNA Metabolic Process Protein Dephosphorylation	Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Intracellular Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Canonical NF-kappaB Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Protein Metabolic Process Regulation Of Immune Response Positive Regulation Of Protein Modification Process CBM Complex Regulation Of Signal Transduction CARD Domain Binding Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Immune Response-activating Signaling Pathway Positive Regulation Of Defense Response Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Immune System Process Regulation Of Signaling Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Protein Modification Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Pattern Recognition Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Interleukin-2 Production Non-canonical NF-kappaB Signal Transduction Innate Immune Response-activating Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Cytokine Production Involved In Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Interleukin-2 Production Lipopolysaccharide-mediated Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Cytokine Production Tumor Necrosis Factor Receptor Superfamily Complex Positive Regulation Of Innate Immune Response Positive Regulation Of Apoptotic Process
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