ASL and HMOX1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ASL	HMOX1
Gene Name		argininosuccinate lyase	heme oxygenase (decycling) 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome	Extracellular Space Nucleus Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Caveola Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Argininosuccinate Lyase Activity	Heme Oxygenase (decyclizing) Activity Phospholipase D Activity Signal Transducer Activity Enzyme Binding Heme Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Urea Cycle Internal Protein Amino Acid Acetylation Arginine Catabolic Process Cellular Nitrogen Compound Metabolic Process Arginine Biosynthetic Process Via Ornithine Small Molecule Metabolic Process	Angiogenesis Endothelial Cell Proliferation Wound Healing Involved In Inflammatory Response Negative Regulation Of Leukocyte Migration Porphyrin-containing Compound Metabolic Process Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Small GTPase Mediated Signal Transduction Excretion Regulation Of Blood Pressure Cell Death Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Muscle Cell Apoptotic Process Smooth Muscle Hyperplasia Cellular Response To Nutrient Negative Regulation Of Mast Cell Cytokine Production Erythrocyte Homeostasis Low-density Lipoprotein Particle Clearance Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Response To Nicotine Intracellular Signal Transduction Heme Catabolic Process Response To Hydrogen Peroxide Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Mast Cell Degranulation Negative Regulation Of DNA Binding Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Response To Estrogen Small Molecule Metabolic Process Positive Regulation Of Chemokine Biosynthetic Process Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Vasodilation Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Homooligomerization Iron Ion Homeostasis Transmembrane Transport Cellular Response To Arsenic-containing Substance Cellular Response To Cadmium Ion Cellular Response To Hypoxia Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Urea cycle Metabolism of amino acids and derivatives	Iron uptake and transport Metabolism of porphyrins Heme degradation
Drugs		L-Arginine Argininosuccinate 2-(N-Morpholino)-Ethanesulfonic Acid	NADH Formic Acid Biliverdine Ix Alpha 12-Phenylheme Heme 2-Phenylheme Verdoheme 1-({2-[2-(4-CHLOROPHENYL)ETHYL]-1,3-DIOXOLAN-2-YL}METHYL)-1H-IMIDAZOLE 1-(adamantan-1-yl)-2-(1H-imidazol-1-yl)ethanone
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: CSNK2A2 FBP1 HMOX1 OVGP1 QARS WDYHV1	10 interactors: AKT1 ASL BLVRB CCDC155 CPSF1 NOS1 POR POT1 TERF1 TUT1
Entrez ID		435	3162
HPRD ID		01948	00782
Ensembl ID		ENSG00000126522	ENSG00000100292
Uniprot IDs		P04424	P09601 Q6FH11
PDB IDs		1AOS 1K62	1N3U 1N45 1NI6 1OYK 1OYL 1OZE 1OZL 1OZR 1OZW 1S13 1S8C 1T5P 1TWN 1TWR 1XJZ 1XK0 1XK1 1XK2 1XK3 3CZY 3HOK 3K4F 3TGM
Enriched GO Terms of Interacting Partners?		Glutaminyl-tRNA Aminoacylation Cellular Response To Metal Ion Prolyl-tRNA Aminoacylation Cellular Response To Inorganic Substance Smooth Muscle Hyperplasia Glutamyl-tRNA Aminoacylation Negative Regulation Of Mast Cell Cytokine Production Cellular Response To Magnesium Ion Negative Regulation Of Binding Of Sperm To Zona Pellucida Smooth Muscle Adaptation Negative Regulation Of Mast Cell Degranulation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Protein Complex Assembly Negative Regulation Of Mast Cell Activation Involved In Immune Response Heme Catabolic Process Protein Homooligomerization Wound Healing Involved In Inflammatory Response Chitin Catabolic Process Chitin Metabolic Process Heme Oxidation Negative Regulation Of Glycolytic Process Cellular Response To Arsenic-containing Substance Response To Metal Ion Negative Regulation Of Mast Cell Activation Positive Regulation Of Chemokine Biosynthetic Process Cellular Response To Iron Ion Cellular Response To Cadmium Ion Endothelial Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Protein Oligomerization Fructose Metabolic Process Response To Magnesium Ion Fructose 6-phosphate Metabolic Process Response To Inorganic Substance Negative Regulation Of Leukocyte Migration Low-density Lipoprotein Particle Clearance Regulation Of Mast Cell Degranulation Response To Arsenic-containing Substance Regulation Of Glycolytic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Vasodilation Cellular Component Assembly Response To Iron Ion Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of Mast Cell Activation Plasma Lipoprotein Particle Clearance Negative Regulation Of Exocytosis Regulation Of Regulated Secretory Pathway Response To Nicotine Mitotic Spindle Checkpoint	Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Arginine Catabolic Process Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Negative Regulation Of Catalytic Activity Regulation Of Telomere Maintenance Via Telomerase Reactive Oxygen Species Metabolic Process Nitric Oxide Biosynthetic Process Positive Regulation Of Organelle Organization Regulation Of Telomerase Activity MRNA Cleavage Arginine Metabolic Process Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Monooxygenase Activity MRNA Polyadenylation Regulation Of Chromosome Organization Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Sodium Ion Transport RNA Polyadenylation Positive Regulation Of Oxidoreductase Activity Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Cellular Metabolic Process Negative Regulation Of Transferase Activity Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Regulation Of Sodium Ion Transport Negative Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Telomere Maintenance Regulation Of Organelle Organization Negative Regulation Of Protein Processing Positive Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Nitrate Catabolic Process Glycogen Cell Differentiation Involved In Embryonic Placenta Development Cellular Organofluorine Metabolic Process Positive Regulation Of DNA Strand Elongation Chromosome Localization To Nuclear Envelope Involved In Synapsis Nitric Oxide Catabolic Process Catabolic Process Regulation Of Oxidoreductase Activity MRNA 3'-end Processing Negative Regulation Of Hydrolase Activity
Tagcloud ?		agnosia argue auditory coded comprehension compromised disruptions english grammar grew impoverished input kleffner landau language lexical linguistic lks manually phonological phonology pitch sign signed speaking spoken syntactic verbal written	alters antioxidative bax cytotoxicity demonstrating ebp endonuclease endoplasmic expressions heme homologous immunoglobulin induces inositol messenger morphological nrf2 overproduction oxygenase reduces requiring simultaneously splicing stimulates tcp trichlorophenol triggered upregulates xbp1
Tagcloud (Difference) ?		agnosia argue auditory coded comprehension compromised disruptions english grammar grew impoverished input kleffner landau language lexical linguistic lks manually phonological phonology pitch sign signed speaking spoken syntactic verbal written	alters antioxidative bax cytotoxicity demonstrating ebp endonuclease endoplasmic expressions heme homologous immunoglobulin induces inositol messenger morphological nrf2 overproduction oxygenase reduces requiring simultaneously splicing stimulates tcp trichlorophenol triggered upregulates xbp1
Tagcloud (Intersection) ?