ASL and MCMBP

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid, two hybrid)

		ASL	MCMBP
Name		argininosuccinate lyase	minichromosome maintenance complex binding protein
Structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytosol Cell Junction MCM Complex
	Molecular Function	Catalytic Activity Argininosuccinate Lyase Activity Protein Binding Lyase Activity Identical Protein Binding	Chromatin Binding Protein Binding
	Biological Process	Urea Cycle Amino Acid Metabolic Process Arginine Metabolic Process L-arginine Biosynthetic Process Locomotory Behavior Amino Acid Biosynthetic Process Post-embryonic Development Ammonia Assimilation Cycle L-arginine Biosynthetic Process Via Ornithine Positive Regulation Of Nitric Oxide Biosynthetic Process L-amino Acid Metabolic Process	DNA Replication DNA-templated DNA Replication Sister Chromatid Cohesion Cell Division
Pathways		Urea cycle	None
Drugs		Arginine Argininosuccinate 2-(N-morpholino)ethanesulfonic acid	None
Diseases		Argininosuccinic aciduria (ARGINSA); Argininosuccinate lyase deficiency	None
GWAS		No GWAS studies recorded	Body size at age 10 ( 32376654 ) Height ( 28552196 )
Interacting Genes		10 interacting genes: CLK1 CSNK2A2 FBP1 HMOX1 MCMBP NTAQ1 OVGP1 QARS1 SRPK2 TRIM3	14 interacting genes: ASL DBF4 DDIT3 FKBP5 KEAP1 MCM3 MCM4 MCM5 MCM6 PRTFDC1 RWDD2A SNW1 USP7 ZNF474
Entrez ID		435	79892
HPRD ID		01948	07624
Ensembl ID		ENSG00000126522	ENSG00000197771
Uniprot IDs		A0A024RDL8 A0A0S2Z316 P04424	A0A0S2Z5P5 Q9BTE3
PDB IDs		1AOS 1K62	4KG9
GO Terms Enriched among Interactors		Protein Serine Kinase Activity Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Catabolic Process Phosphoric Ester Hydrolase Activity Cellular Response To Raffinose Fructose 1,6-bisphosphate 1-phosphatase Activity Heme Oxidation Smooth Muscle Hyperplasia Heme Oxygenase (decyclizing) Activity Wound Healing Involved In Inflammatory Response Perivitelline Space Glutamine-tRNA Ligase Activity Glutaminyl-tRNA Aminoacylation Protein-N-terminal Asparagine Amidohydrolase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Regulation Of Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Protein Kinase CK2 Complex Cellular Hypotonic Salinity Response Cytosol Cellular Response To Cisplatin Negative Regulation Of Binding Of Sperm To Zona Pellucida Egg Coat Nuclear Speck Organization	CMG Complex Double-strand Break Repair Via Break-induced Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation DNA Replication Initiation Regulation Of DNA Replication DNA Replication Single-stranded DNA Helicase Activity DNA Damage Response Regulation Of DNA Metabolic Process Single-stranded DNA Binding Helicase Activity Mitotic DNA Replication Initiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cellular Response To Stress Chromosome, Telomeric Region DNA Metabolic Process Double-strand Break Repair DNA Recombination DNA Repair DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Chromosome ATP Hydrolysis Activity Nucleobase-containing Compound Metabolic Process DNA Helicase Activity Transcription Regulator Inhibitor Activity Nucleic Acid Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Argininosuccinate Lyase Activity Ammonia Assimilation Cycle Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Nucleoplasm L-arginine Biosynthetic Process Via Ornithine Nitrogen Utilization Negative Regulation Of Determination Of Dorsal Identity Response To Stress Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction CHOP-ATF4 Complex CHOP-ATF3 Complex Dbf4-dependent Protein Kinase Complex Hypoxanthine Phosphoribosyltransferase Activity Guanine Salvage CHOP-C/EBP Complex Diaphragm Contraction Vascular Associated Smooth Muscle Cell Migration Single-stranded 3'-5' DNA Helicase Activity Mitotic DNA Replication Symbiont-mediated Disruption Of Host Cell PML Body