ASL and FBP1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ASL	FBP1
Gene Name		argininosuccinate lyase	fructose-1,6-bisphosphatase 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Argininosuccinate Lyase Activity	Protein Binding AMP Binding Fructose 1,6-bisphosphate 1-phosphatase Activity Identical Protein Binding Metal Ion Binding Monosaccharide Binding
	Biological Process	Urea Cycle Internal Protein Amino Acid Acetylation Arginine Catabolic Process Cellular Nitrogen Compound Metabolic Process Arginine Biosynthetic Process Via Ornithine Small Molecule Metabolic Process	Carbohydrate Metabolic Process Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Glucose Metabolic Process Gluconeogenesis Regulation Of Gluconeogenesis Pathogenesis Dephosphorylation Negative Regulation Of Cell Growth Cellular Response To Drug Small Molecule Metabolic Process Negative Regulation Of Glycolytic Process Negative Regulation Of Ras Protein Signal Transduction Protein Homotetramerization Cellular Response To Magnesium Ion
Pathways		Urea cycle Metabolism of amino acids and derivatives	Gluconeogenesis Glucose metabolism Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs		L-Arginine Argininosuccinate 2-(N-Morpholino)-Ethanesulfonic Acid
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: CSNK2A2 FBP1 HMOX1 OVGP1 QARS WDYHV1	20 interactors: ACTN1 ASCC2 ASL ATP5J2 BCL2L1 BIN1 CSNK1E DYNC1I1 FBP2 FXR2 HDAC6 HSPA8 KLRC2 LNX1 PARK2 PCNXL4 POT1 PTK2 RNF183 TERF1
Entrez ID		435	2203
HPRD ID		01948	01973
Ensembl ID		ENSG00000126522	ENSG00000165140
Uniprot IDs		P04424	P09467 Q2TU34
PDB IDs		1AOS 1K62	1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1
Enriched GO Terms of Interacting Partners?		Glutaminyl-tRNA Aminoacylation Cellular Response To Metal Ion Prolyl-tRNA Aminoacylation Cellular Response To Inorganic Substance Smooth Muscle Hyperplasia Glutamyl-tRNA Aminoacylation Negative Regulation Of Mast Cell Cytokine Production Cellular Response To Magnesium Ion Negative Regulation Of Binding Of Sperm To Zona Pellucida Smooth Muscle Adaptation Negative Regulation Of Mast Cell Degranulation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Protein Complex Assembly Negative Regulation Of Mast Cell Activation Involved In Immune Response Heme Catabolic Process Protein Homooligomerization Wound Healing Involved In Inflammatory Response Chitin Catabolic Process Chitin Metabolic Process Heme Oxidation Negative Regulation Of Glycolytic Process Cellular Response To Arsenic-containing Substance Response To Metal Ion Negative Regulation Of Mast Cell Activation Positive Regulation Of Chemokine Biosynthetic Process Cellular Response To Iron Ion Cellular Response To Cadmium Ion Endothelial Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Protein Oligomerization Fructose Metabolic Process Response To Magnesium Ion Fructose 6-phosphate Metabolic Process Response To Inorganic Substance Negative Regulation Of Leukocyte Migration Low-density Lipoprotein Particle Clearance Regulation Of Mast Cell Degranulation Response To Arsenic-containing Substance Regulation Of Glycolytic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Vasodilation Cellular Component Assembly Response To Iron Ion Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of Mast Cell Activation Plasma Lipoprotein Particle Clearance Negative Regulation Of Exocytosis Regulation Of Regulated Secretory Pathway Response To Nicotine Mitotic Spindle Checkpoint	Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Via Telomerase Aggresome Assembly Positive Regulation Of Oxidative Stress-induced Cell Death Cellular Localization Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Negative Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Via Telomerase Cellular Component Assembly Regulation Of Organelle Organization Negative Regulation Of Anoikis Regulation Of Telomerase Activity Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cell Death Regulation Of Anoikis Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Telomere Maintenance Regulation Of Proteolysis RNA-dependent DNA Replication Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of DNA Biosynthetic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Mitochondrion Organization Establishment Of Localization In Cell Regulation Of Proteasomal Protein Catabolic Process Regulation Of Cytoskeleton Organization Vesicle-mediated Transport Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Fibril Organization Apoptotic Process In Bone Marrow Positive Regulation Of Mitochondrial Fusion Positive Regulation Of DNA Strand Elongation Hsp90 Deacetylation Positive Regulation Of Apoptotic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Tagcloud ?		agnosia argue auditory coded comprehension compromised disruptions english grammar grew impoverished input kleffner landau language lexical linguistic lks manually phonological phonology pitch sign signed speaking spoken syntactic verbal written	abundantly albeit antagonizes bccip fuse hepatocellular hypothesize impairing implication interacted interacts knockdown oncogene p21 p53 physically proapoptotic protein1 proto radiation restored stably suppresses tctp transactivation transactivator tumorigenesis undifferentiated
Tagcloud (Difference) ?		agnosia argue auditory coded comprehension compromised disruptions english grammar grew impoverished input kleffner landau language lexical linguistic lks manually phonological phonology pitch sign signed speaking spoken syntactic verbal written	abundantly albeit antagonizes bccip fuse hepatocellular hypothesize impairing implication interacted interacts knockdown oncogene p21 p53 physically proapoptotic protein1 proto radiation restored stably suppresses tctp transactivation transactivator tumorigenesis undifferentiated
Tagcloud (Intersection) ?