ASL

Gene Name		argininosuccinate lyase
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Argininosuccinate Lyase Activity
	Biological Process	Urea Cycle Internal Protein Amino Acid Acetylation Arginine Catabolic Process Cellular Nitrogen Compound Metabolic Process Arginine Biosynthetic Process Via Ornithine Small Molecule Metabolic Process
Pathways		Urea cycle Metabolism of amino acids and derivatives
Drugs		L-Arginine Argininosuccinate 2-(N-Morpholino)-Ethanesulfonic Acid
Diseases
GWAS
Protein-protein Interactions		6 interactors: CSNK2A2 FBP1 HMOX1 OVGP1 QARS WDYHV1
Entrez ID		435
HPRD ID		01948
Ensembl ID		ENSG00000126522
Uniprot IDs		P04424
PDB IDs		1AOS 1K62
Enriched GO Terms of Interacting Partners?		Glutaminyl-tRNA Aminoacylation Cellular Response To Metal Ion Prolyl-tRNA Aminoacylation Cellular Response To Inorganic Substance Smooth Muscle Hyperplasia Glutamyl-tRNA Aminoacylation Negative Regulation Of Mast Cell Cytokine Production Cellular Response To Magnesium Ion Negative Regulation Of Binding Of Sperm To Zona Pellucida Smooth Muscle Adaptation Negative Regulation Of Mast Cell Degranulation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Protein Complex Assembly Negative Regulation Of Mast Cell Activation Involved In Immune Response Heme Catabolic Process Protein Homooligomerization Wound Healing Involved In Inflammatory Response Chitin Catabolic Process Chitin Metabolic Process Heme Oxidation Negative Regulation Of Glycolytic Process Cellular Response To Arsenic-containing Substance Response To Metal Ion Negative Regulation Of Mast Cell Activation Positive Regulation Of Chemokine Biosynthetic Process Cellular Response To Iron Ion Cellular Response To Cadmium Ion Endothelial Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Protein Oligomerization Fructose Metabolic Process Response To Magnesium Ion Fructose 6-phosphate Metabolic Process Response To Inorganic Substance Negative Regulation Of Leukocyte Migration Low-density Lipoprotein Particle Clearance Regulation Of Mast Cell Degranulation Response To Arsenic-containing Substance Regulation Of Glycolytic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Vasodilation Cellular Component Assembly Response To Iron Ion Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of Mast Cell Activation Plasma Lipoprotein Particle Clearance Negative Regulation Of Exocytosis Regulation Of Regulated Secretory Pathway Response To Nicotine Mitotic Spindle Checkpoint
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