HMGA1 and RBFOX2

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (proximity labelling technology, two hybrid)

		HMGA1	RBFOX2
Description		high mobility group AT-hook 1	RNA binding fox-1 homolog 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytosol Focal Adhesion Nuclear Membrane Senescence-associated Heterochromatin Focus RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding DNA Binding, Bending Enzyme Binding Structural Constituent Of Chromatin Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Nuclear Retinoid X Receptor Binding 5'-deoxyribose-5-phosphate Lyase Activity Molecular Adaptor Activity Molecular Function Activator Activity	Nucleic Acid Binding Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Base-excision Repair Nucleosome Disassembly Regulation Of DNA-templated Transcription Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Oncogene-induced Cell Senescence	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development RNA Splicing RNA Metabolic Process Estrogen Receptor Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of RNA Splicing Negative Regulation Of DNA-templated Transcription
Pathways		Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Formation of Senescence-Associated Heterochromatin Foci (SAHF)	FGFR2 alternative splicing
Drugs
Diseases
GWAS		A body shape index ( 34021172) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Body mass index ( 20935630 28892062 26426971) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 19343178 34054925 31562340 20881960 18391951 19396169 19893584 20189936 20397748 21998595 23563607 25282103 25429064) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 25673412 34021172) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Myeloproliferative neoplasms ( 33057200) Offspring birth weight ( 31043758) Plateletcrit ( 32888494) Regular attendance at a gym or sports club ( 29970889) Systolic blood pressure ( 30578418) Tonsillectomy ( 28928442 27182965) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Type 2 diabetes (adjusted for BMI) ( 30297969) Uterine fibroids ( 31649266) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 28552196 34021172 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 25673412) Weight ( 34054925)	Body size at age 10 ( 32376654) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reading disability or specific language impairment (pleiotropy) ( 25065397) Red cell distribution width ( 32888494) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		71 interacting genes: ANXA1 ANXA2 APEX1 APP ATF2 ATM CD274 CDK1 CEBPA CEBPB CREBBP CSNK2A1 CSNK2A2 CWC27 DNAJC8 EIF2S2 ELF1 EPB41L2 EWSR1 GTF2F2 HEMGN HIPK2 HMGB1 HMGB2 HMGB3 HNRNPA1 HNRNPAB HNRNPD HNRNPDL HNRNPL HPF1 HSPA1A IRF1 JUN KAT2B MAPK1 METAP2 NCL NFKB1 NFYA NPM1 OLA1 ORC6 PA2G4 PCBP1 PCBP2 POU2F1 POU2F2 POU3F1 PPARG PPP1R8 PRKCA PRMT6 PSIP1 PTBP1 RARA RARG RBFOX2 RCC1 RN7SK RNF4 RXRA SP1 SRF SRPK2 SSB SUFU SYNCRIP TP53 UPF2 WEE2-AS1	182 interacting genes: ADARB1 ALG13 ANKHD1 APH1A ATN1 ATXN1 ATXN1L BAG4 BOLL C1orf94 CALD1 CAMK2A CAMK2B CHAF1A CHERP CLASP2 CPSF7 DAB1 DAZAP2 DDX21 DDX5 DEDD2 DENND1B DMRTB1 EIF4ENIF1 ELAVL1 ELAVL2 ESR1 ESR2 FAM168B FBXO7 FSAF1 GIMAP4 GLIS2 GTF2A1L H1-4 HMGA1 HNRNPAB HNRNPF HNRNPH1 HNRNPH2 HNRNPK KHDRBS1 KHDRBS2 KIF20A KRT31 KRTAP6-2 LMNA LSM5 MAGED1 MAPK1IP1L MBNL1 MED7 MIR1-1 MIR106A MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-2 MIR140 MIR141 MIR143 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR9-1 MIR9-2 MIR9-3 MIR93 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MRPL4 MSI2 MTG1 MYO1C NAF1 NLGN3 NOL8 NR2E3 NXF1 OGT OXER1 PA2G4 PCBP1 PCBP2 PCNP PDIA3 PEG10 POLR3D PPIL4 PRMT5 PRPF19 PRPF38B PRRC2B PSMA3 PSMF1 PTBP1 PURB QARS1 QKI RBFOX1 RBFOX3 RBM12 RBM17 RBM22 RBM23 RBM42 RBPMS RBPMS2 RERE RHOXF2 RNF8 RPL3 RPL4 RPN1 RPS13 RPS28 SDHC SF1 SF3A1 SF3B3 SF3B4 SMN1 SNRPA SNRPC SNW1 SPATS2L SPMIP9 SPOP SRP68 ST13 SUPV3L1 SURF6 TNRC6A TOLLIP U2AF2 UBQLN2 VAC14 YTHDF1 YTHDF3 ZC3H10 ZNF137P
Entrez ID		3159	23543
HPRD ID		02829	15231
Ensembl ID		ENSG00000137309	ENSG00000100320
Uniprot IDs		A0A994J434 P17096 Q5T6U8	A0A8Q3WKT3 O43251
PDB IDs		2EZD 2EZE 2EZF 2EZG 8CPG	2CQ3
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Regulation Of RNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Chromatin Regulation Of Metabolic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression RNA Polymerase II Transcription Regulator Complex DNA Binding Chromatin Binding MRNA Metabolic Process Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Binding Gland Development Regulation Of Cell Population Proliferation DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Binding Regulation Of Programmed Cell Death Negative Regulation Of Gene Expression Sequence-specific DNA Binding Chromatin Remodeling Nucleic Acid Binding	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity RISC Complex Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of MRNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process RNA Binding Extracellular Vesicle Positive Regulation Of MRNA Catabolic Process Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Translation Nucleic Acid Binding Regulation Of Translation Regulation Of RNA Stability Regulation Of MRNA Stability Regulation Of RNA Splicing MRNA Binding Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Primary Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway MRNA Processing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process RNA Processing Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Regulation Of Vasculature Development
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?