HMGA1 and EPB41L2

Number of citations of the paper that reports this interaction (PubMedID 38341427)
45

Data Source:
BioGRID (unspecified method)

		HMGA1	EPB41L2
Description		high mobility group AT-hook 1	erythrocyte membrane protein band 4.1 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Cytosol Focal Adhesion Nuclear Membrane Senescence-associated Heterochromatin Focus RNA Polymerase II Transcription Regulator Complex	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Spectrin COP9 Signalosome Membrane Cell Junction Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Binding DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding DNA Binding, Bending Enzyme Binding Structural Constituent Of Chromatin Nuclear Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Nuclear Retinoid X Receptor Binding 5'-deoxyribose-5-phosphate Lyase Activity Molecular Adaptor Activity Molecular Function Activator Activity	Actin Binding Structural Molecule Activity Protein Binding Cytoskeletal Protein Binding Spectrin Binding PH Domain Binding
	Biological Process	Base-excision Repair Nucleosome Disassembly Regulation Of DNA-templated Transcription Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Oncogene-induced Cell Senescence	Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Cell Division Positive Regulation Of Protein Localization To Cell Cortex
Pathways		Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Neurexins and neuroligins
Drugs
Diseases
GWAS		A body shape index ( 34021172) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Birth weight ( 31043758 27680694) Body mass index ( 20935630 28892062 26426971) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 19343178 34054925 31562340 20881960 18391951 19396169 19893584 20189936 20397748 21998595 23563607 25282103 25429064) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 25673412 34021172) Lung function (FVC) ( 30804560) Lymphocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 31589552) Myeloproliferative neoplasms ( 33057200) Offspring birth weight ( 31043758) Plateletcrit ( 32888494) Regular attendance at a gym or sports club ( 29970889) Systolic blood pressure ( 30578418) Tonsillectomy ( 28928442 27182965) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Type 2 diabetes (adjusted for BMI) ( 30297969) Uterine fibroids ( 31649266) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 28552196 34021172 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 25673412) Weight ( 34054925)	Appendicular lean mass ( 33097823) Cerebellum white matter volume ( 31530798) Colorectal cancer (calcium intake interaction) ( 25192705) Creativity ( 32133506) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Lentiform nucleus volume ( 22903471) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Pars triangularis volume ( 31530798) Plateletcrit ( 32888494) Response to statins (LDL cholesterol change) ( 22331829) Systolic blood pressure ( 30224653) Urolithiasis ( 30975718)
Interacting Genes		71 interacting genes: ANXA1 ANXA2 APEX1 APP ATF2 ATM CD274 CDK1 CEBPA CEBPB CREBBP CSNK2A1 CSNK2A2 CWC27 DNAJC8 EIF2S2 ELF1 EPB41L2 EWSR1 GTF2F2 HEMGN HIPK2 HMGB1 HMGB2 HMGB3 HNRNPA1 HNRNPAB HNRNPD HNRNPDL HNRNPL HPF1 HSPA1A IRF1 JUN KAT2B MAPK1 METAP2 NCL NFKB1 NFYA NPM1 OLA1 ORC6 PA2G4 PCBP1 PCBP2 POU2F1 POU2F2 POU3F1 PPARG PPP1R8 PRKCA PRMT6 PSIP1 PTBP1 RARA RARG RBFOX2 RCC1 RN7SK RNF4 RXRA SP1 SRF SRPK2 SSB SUFU SYNCRIP TP53 UPF2 WEE2-AS1	17 interacting genes: ACTA1 ADORA1 APP ATXN1L DRD1 DRD3 FKBP2 GRIA1 GRM1 HMGA1 HSPB1 NUMA1 PARP1 RNF10 SPTAN1 VIM YWHAH
Entrez ID		3159	2037
HPRD ID		02829	09126
Ensembl ID		ENSG00000137309	ENSG00000079819
Uniprot IDs		A0A994J434 P17096 Q5T6U8	A0A994J5B1 B4DJ76 E9PHY5 E9PII3 I6L9B1 O43491 Q59FD8
PDB IDs		2EZD 2EZE 2EZF 2EZG 8CPG
Enriched GO Terms of Interacting Partners?		Nucleoplasm Nucleus Regulation Of RNA Metabolic Process Nucleic Acid Metabolic Process Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Chromatin Regulation Of Metabolic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression RNA Polymerase II Transcription Regulator Complex DNA Binding Chromatin Binding MRNA Metabolic Process Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Binding Gland Development Regulation Of Cell Population Proliferation DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Binding Regulation Of Programmed Cell Death Negative Regulation Of Gene Expression Sequence-specific DNA Binding Chromatin Remodeling Nucleic Acid Binding	Regulation Of Nervous System Process Regulation Of Membrane Potential Negative Regulation Of Synaptic Transmission Dendrite Modulation Of Chemical Synaptic Transmission Cognition Learning Long-term Synaptic Depression Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Neurotransmitter Uptake Cell Body Regulation Of Synaptic Plasticity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Associative Learning Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Learning Or Memory Memory Positive Regulation Of Synaptic Transmission Regulation Of System Process Nervous System Process Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Chemical Synaptic Transmission Response To Cocaine Dopamine Neurotransmitter Receptor Activity Dendritic Spine Cell-cell Signaling Synapse Regulation Of Metal Ion Transport Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Heterotrimeric G-protein Binding Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Visual Learning Signaling Regulation Of Dopamine Uptake Involved In Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Cell Communication Visual Behavior System Process Negative Regulation Of Synaptic Transmission, Glutamatergic Locomotory Behavior Glial Cell Development Regulation Of Biological Quality Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Regulation Of Behavior Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Amine Transport
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